International Journal of Cancer, Volume 159, Issue 3, Page 719-728, 1 August 2026.What's New? The emerging role of immunotherapy in small‐cell lung cancer treatment has not been fully elucidated, particularly outside of clinical trials. This single‐center retrospective cohort study examined real‐world treatment patterns and overall survival in South Korea during the 2018–2023 period.
Sehhoon Park +11 more
wiley +1 more source
PARP inhibitors in gastric cancer: unlocking precision oncology. [PDF]
OncologistTai D +10 more
europepmc +1 more source
Journal of Applied Toxicology, Volume 46, Issue 8, Page 2599-2622, August 2026.ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza +2 more
wiley +1 more source
PARP Inhibitors and the Risk of Serum Creatinine Elevation in Ovarian Cancer: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. [PDF]
Cancers (Basel)Gąsowska-Bodnar A +4 more
europepmc +1 more source
The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis
British Journal of Pharmacology, Volume 183, Issue 15, Page 4126-4144, August 2026.Background and Purpose Acute pancreatitis (AP) is a multifactorial upper gastrointestinal inflammatory disorder that in severe cases (~20% of all AP) is associated with substantial morbidity and mortality, the latter coincident with multiorgan dysfunction, particularly acute lung injury (ALI).
Shermin Chan +17 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, Volume 16, Issue 7, Page 1370-1386, July 2026.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Impact of adverse events-associated dose modifications of PARP inhibitors on treatment outcomes in primary ovarian cancer. [PDF]
J Ovarian ResFu Y +6 more
europepmc +1 more source
The Chemical Regulatory Landscape of Biomolecular Condensates
Aggregate, Volume 7, Issue 7, July 2026.Chemical regulation of biomolecular phase separation offers a unique opportunity to bridge molecular‐level chemistry with emergent cellular organization. Chemically informed strategies for controlling condensate condensates through chemically tractable parameters such as interaction valency, solvent quality, and molecular crowding provides a unifying ...
Di Liu, Xin Zhang
wiley +1 more source
Nicotinamide Reverses the Warburg Effect in CHO Cell Culture
Biotechnology and Bioengineering, Volume 123, Issue 7, Page 1902-1915, July 2026.ABSTRACT The Warburg effect, the preferential conversion of glucose‐derived pyruvat to lactate despite available oxygen, is a key feature of Chinese hamster ovary (CHO) cell culture. Lactate accumulation in recombinant protein‐producing cell culture is an inefficient usage of glucose, as well as being deleterious to cells.
James Morrissey +7 more
wiley +1 more source
Expert opinion on the management of anemia in prostate cancer patients receiving PARP inhibitors. [PDF]
Can Urol Assoc JHanna L +5 more
europepmc +1 more source