Results 91 to 100 of about 4,502,161 (251)

Variations in linear energy transfer distributions within a European proton therapy planning comparison of paediatric posterior fossa tumours

Physics and Imaging in Radiation Oncology
Background and Purpose: Radiotherapy for paediatric posterior fossa tumours may cause complications in the brainstem and upper spinal cord due to high doses. With proton therapy (PT) this risk may increase due to higher relative biological effectiveness (
Peter Lægdsmand, Witold Matysiak, Ludvig P. Muren, Yasmin Lassen-Ramshad, John H. Maduro, Anne Vestergaard, Roberto Righetto, Erik Pettersson, Ingrid Kristensen, Pauline Dutheil, Charlotte Demoor-Goldschmidt, Frances Charlwood, Gillian Whitfield, Marta M. Feijoo, Anthony Vela, Fernand Missohou, Sabina Vennarini, Alfredo Mirandola, Ester Orlandi, Barbara Rombi, Anneleen Goedgebeur, Karen Van Beek, Agata Bannink-Gawryszuk, Fernando C. Campoo, Jacob Engellau, Laura Toussaint   +25 more
doaj   +1 more source

Iron‐Tannic Acid Hydrogel Mediated Mild Photothermal Therapy Combined With Ferroptosis Enhances Anti‐Tumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An injectable gelatin‐based tannic acid–iron hydrogel with mild photothermal therapy could not only induce immunogenic cell death, but also elicit ferroptosis of both tumor cells and tumor‐associated macrophages, resulting in DC maturation, T‐cell infiltration and down‐regulation of ferroptosis‐sensitive M2‐type TAMs levels.
Yuan Zhu, Xi Yu, Tao Wang, Wanyi Liu, Chang Lu, Jiani Zhong, Yujie He, Wei Li, Kunxi Zhang, Peihao Yin, Zeting Yuan   +10 more
wiley   +1 more source

Investigating the Secondary Thermal Neutron Intensity of Neutron Capture-Enhanced Proton Therapy

Applied Sciences
This study aimed to investigate the distribution of thermal neutron fluence generated during proton-beam therapy (PBT) scanning, focusing on neutrons produced within the body using Monte Carlo simulations (MCSs).
Takahiro Shimo, Shintaro Shiba, Hiroyuki Watanabe, Masashi Yamanaka, Kazuki Matsumoto, Akihiro Yamano, Hisato Nagano, Kohichi Tokuuye   +7 more
doaj   +1 more source

Carbon-ion Radiotherapy for Isolated Lymph Node Metastasis After Surgery or Radiotherapy for Lung Cancer

Frontiers in Oncology, 2019
Purpose: Mediastinal and hilar lymph node metastasis is one of the recurrence patterns after definitive treatment of lung cancer. Salvage radiotherapy (RT) can be a treatment option for lymph node metastasis.
Katsuyuki Shirai, Katsuyuki Shirai, Yoshiki Kubota, Tatsuya Ohno, Jun-ichi Saitoh, Takanori Abe, Tatsuji Mizukami, Yasumasa Mori, Hidemasa Kawamura, Keiko Akahane, Takashi Nakano   +10 more
doaj   +1 more source

Multiplexed Profiling of Individual Extracellular Vesicles Reveals Lung Cancer‐Associated Protein Signatures

Advanced Science, EarlyView.
Cygnus (Cyclic‐imaging gateway to nanovesicles underlying signature) integrates multiplexed single‐EV protein imaging with a practical analysis workflow to examine EV phenotypes at vesicle, subpopulation, and sample scales. ABSTRACT Lung cancer is frequently diagnosed after curative treatment windows have narrowed, creating a need for minimally ...
Mi Hyeon Cho, Yein Chung, Yoonjeong Choi, Baekdong Cha, Jayeon Song, Nuri Oh, Ala Jo, Thomas S. C. Ng, Hyunho Kim, Hyun‐Kyung Woo, Chang Hyun Kim, Cesar M. Castro, Miles A. Miller, Hakho Lee   +13 more
wiley   +1 more source

Commissioning a beam line for MR‐guided particle therapy assisted by in silico methods

, 2023
Background Radiation therapy is continuously moving towards more precise dose delivery. The combination of online MR imaging and particle therapy, for example, radiation therapy using protons or carbon ions, could enable the next level of precision in ...
Fatima Padilla‐Cabal, Oborn, Bradley M., Georg, Dietmar, Bradley M. Oborn, Fuchs, Hermann, Dietmar Georg, Hermann Fuchs, Padilla-Cabal, Fatima   +7 more
core   +1 more source

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Comprehensive analysis of Japanese nationwide cohort data of particle beam therapy for pulmonary, liver and lymph node oligometastases: particle beam therapy versus high-precision X-ray radiotherapy. [PDF]

J Radiat Res, 2023
Aibe N, Ogino H, Wakatsuki M, Fujikawa K, Teramukai S, Fukumitsu N, Shiba S, Yamamoto N, Nomoto A, Ono T, Oguri M, Yamaguchi H, Numajiri H, Shibuya K, Okazaki S, Miyasaka Y, Okonogi N, Murata K, Tatebe H, Motegi A, Okimoto T, Yoshino T, Mandai M, Katoh N, Tsuji H, Sakurai H.   +25 more
europepmc   +1 more source

QA Guideline for Particle Beam Therapy Equipment

, 2013
Introduction: The first particle beam therapy equipment QA guideline [1] was published from Japan in 2005. However, the QA procedure, tolerance values, action levels, etc.
698308, 698307, Fukumura, Akifumi, 698306, 福村 明史, et.al   +5 more
core  

Characterization of a supersonic molecular beam for charged particle beam profile monitor

, 2022
In the present work, we report an experimental method to measure the density and distribution of a supersonic molecular beam used for charged particle beam profile monitoring. The density of the molecular beam used in this monitor was in the range of $10^
Welsch, C.P., Salehilashkajani, A, Salehilashkajani, A., Welsch, CP, Zhang, HD, Zhang, H.D., Sedlacek, O., Sedlacek, O, Zhang H, Welsch C, Salehilashkajani A, Sedlacek O   +11 more
core   +1 more source