Results 131 to 140 of about 4,502,161 (251)

Temporal Trajectories of the Tau Aggregate Interactome Reveal Stage‐Specific Vulnerabilities in Alzheimer's Disease

Advanced Science, EarlyView.
Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken, Paula Beltran Lobo, Yunzhao Wu, Lyla A. Rowe, Emre Fertan, Cara L. Croft, Maria Jimenez‐Sanchez, Dezerae Cox, David Klenerman   +8 more
wiley   +1 more source

Granzyme B PET Imaging Reveals Lgmn+ Macrophage‐Mediated Immune Evasion and Guides Immunotherapy in EGFR‐TKI‐Resistant NSCLC

Advanced Science, EarlyView.
Graphical illustration of 68Ga‐GZB PET/CT imaging reveals immune dynamics post‐EGFR‐TKI resistance in NSCLC; Lgmn+ macrophages‐derived Lgmn‐containing extracellular vesicles inhibit glycolysis, induce CD8+ T cell exhaustion, and targeting Lgmn restores immunotherapy sensitivity.
Dongliang Wang, Wenqin Luo, Qiufang Liu, Wenxuan Tang, Bin Zhu, Jiwei Chen, Qian Zhou, Shuang Tang, Xiaoping Xu, Shaoli Song   +9 more
wiley   +1 more source

Beam injection issues of FFAG for particle therapy

, 2016
Spot scanning irradiation is a novel and powerful scheme for particle therapy. The pulsed beam structure of FFAG (Fixed Field Alternating Gradient) accelerator is suitable for the scheme.

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A stochastic framework for spot-scanning particle therapy

, 2016
International audienceIn spot-scanning particle therapy, inverse treatment planning is usually limited to finding the optimal beam fluences given the beam trajectories and energies.
Marc Robini, Robini, Marc, Magnin, Isabelle, E., Wanyu Liu, Yuemin Zhu, Liu, Wanyu, Zhu, Yuemin, Isabelle Magnin   +7 more
core   +1 more source

Real‐Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids

Advanced Science, EarlyView.
This study introduces photothermally actuated microcantilevers combined with optical microscopy to simultaneously measure morphology, mass, and mechanical properties of cellular systems in real‐time. The findings link cytoplasm‐dominated mechanical energy dissipation to the Q‐factor as a novel biophysical parameter.
Ilaria Incaviglia, Giulia E. M. Ammirati, Sophie Herzog, Tommy Krug, Nico Strohmeyer, Miguel Camacho Rufino, Matthias P. Lutolf, David A. Weitz, Daniel J. Müller   +8 more
wiley   +1 more source

Particle therapy for intrahepatic cholangiocarcinoma: A multicenter prospective registry study, systematic review and meta-analysis

Liver Cancer
Introduction: A prospective study was started in May 2016 to evaluate the efficacy and safety of particle therapy for intrahepatic cholangial carcinoma (ICC).
Masashi Mizumoto, Kei Shibuya, Kazuki Terashima, Masao Murakami, Motohiro Murakami, Yoshiyuki Shioyama, Yoshiro Matsuo, Takashi Ogino, Tatsuya Ohno, Takahiro Waki, Hiroyuki Ogino, Hiroyasu Tamamura, Norio Katoh, Masaru Wakatsuki, Tomoaki Okimoto, Motohisa Suzuki, Takashi Saito, Shingo Toyama, Takayuki Hashimoto, Hisateru Ohba, Shoji Kubo, Kiyoshi Hasegawa, Kazushi Maruo, Hideyuki Sakurai   +23 more
doaj   +1 more source

Generative AI‐Enabled Discovery and Experimental Demonstration of Ultra‐Broadband Epsilon‐Near‐Zero Perfect Absorbers

Advanced Science, EarlyView.
Researchers developed and applied a generative artificial intelligence (AI) model to optimize epsilon‐near‐zero thin film stacks for ultra‐broadband perfect absorption of light. The fabricated AI‐designed absorber, with a total thickness of only 160 nm, experimentally demonstrated an absorption bandwidth exceeding 1000 nm while maintaining greater than
David Dang, Meena Salib, Quynh Dang, Sudip Gurung, Juan Calixto, Xuguo Zhou, Stuart Love, Massee Akbar, Aleksei Anopchenko, Wilton J.M. Kort‐Kamp, Ho Wai Howard Lee   +10 more
wiley   +1 more source

Carbon Ion Beam Reirradiation in Recurrent High-Grade Glioma

Cancer Management and Research, 2020
Fabian Eberle, 1–4 Stefan Lautenschläger, 4 Rita Engenhart-Cabillic, 1, 3, 4 Alexandra D Jensen, 5 Barbara Carl, 6 Marco Stein, 7 Jürgen Debus, 1–3, 8–11 Henrik Hauswald 1–4, 8, 10, 11 1Department of Radiation Oncology,
Eberle F, Lautenschläger S, Engenhart-Cabillic R, Jensen AD, Carl B, Stein M, Debus J, Hauswald H   +7 more
doaj  

3-dimensional beam scanning system for particle radiation therapy

, 1977
In radiation therapy treatment volumes up to several liters have to be irradiated. Today's charged particle programs use ridge filters, scattering foils, occluding rings collimators and boluses to shape the dose distribution.
Staples, J., Kalnins, G., Rondeau, D., Hoyer, E., Grunder, H., Alonso, J., Leemann, C., Voelker, F.   +7 more
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Development of an IH-DTL injector for the Heidelberg cancer therapy project [PDF]

, 2005
Cancer has become one of the most fatal diseases. The Heidelberg Heavy Ion Cancer Therapy (HICAT) has the potential to become an important and efficient treatment method because of its excellent “Bragg peak” characteristics and on-line irradiation ...
Lu, Yuanrong
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