Results 71 to 80 of about 3,434,853 (290)

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Aerosols in the tropical and subtropical UT/LS: in-situ measurements of submicron particle abundance and volatility [PDF]

, 2009
Processes occurring in the tropical upper troposphere (UT), the Tropical Transition Layer (TTL), and the lower stratosphere (LS) are of importance for the global climate, for stratospheric dynamics and air chemistry, and for their influence on the global
Curtius, Joachim, Homan, C., Shur, G., Belyaev, G. V., Homan, Carine D., Belyaev, Gennady, Weigel, R., Wilson, J. C., Belyaev, Gennady V., Deshler, Terry, K. S. Law, Borrmann, Stephan, Shur, G. N., A. Minikin, G. N. Shur, Cairo, F., J. C. Wilson, Kunkel, D., Shur, Genrikh N., D. Kunkel, S. Viciani, Deshler, T., Law, K., Belyaev, G., A. Ulanovsky, Homan, C. D., Minikin, Andreas, G. V. Belyaev, Weigel, Ralf, Law, K. S., T. Deshler, Minikin, A., Kunkel, Daniel, S. Borrmann, Shur, Genrih N., Wilson, J., Volk, C.-Michael, C. M. Volk, Ulanovsky, A., F. Cairo, Viciani, Silvia, Wilson, James C., Cairo, Francesco, C. D. Homan, Curtius, J., Viciani, S., J. Curtius, Belyaev, D., R. Weigel, Borrmann, S., Law, Kathy S., Volk, C., Volk, C. Michael, Ravegnani, F., F. Ravegnani, Volk, C. M., Ravegnani, Fabrizio, Ulanovsky, Alexey   +57 more
core   +2 more sources

Geochemical Influences on Carbon Nanotubes Transport in Subsurface Environments: Integrating Millifluidics, Spectral Induced Polarization, and Machine Learning

Geophysical Research Letters
Understanding nanoparticles, like carbon nanotube (CNT), transport and retention in porous media is critical for environmental risk assessment and remediation. Millifluidic visualization, spectral induced polarization (SIP), and deep neural network (DNN)
Yixin Yang, Pengfei Liu, Kexin Chen, Sheng Zhou, Longlong Meng, Chi Zhang, Junnan Cao, Bate Bate   +7 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The effects of physical activity on pollutant particle deposition in the realistic human lung airways

, 2021
Pollutant particles emission has been a major source of worry for many years due to their negative health impacts. For health risk assessment, it is critical to understand how to assess pollutant particles transportation and deposition (TD) in human lung
Islam, Mohammad S., Zhao, Ming (R16667), Rahman, M. Mizanur (S35371), Saha, Suvash C., Dong, Kejun (R17842)   +4 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

On the role of onshore geostrophic flow on larval retention in a permanent upwelling zone along north-central Chile

Frontiers in Marine Science
The Humboldt Archipelago (HAp), located off north-central Chile (~28° - 33° S) is one of the most productive marine zones of the Humboldt Current System (HCS).
Eduardo A. Flores, Eduardo A. Flores, Marcel Ramos, Marcel Ramos, Marcel Ramos, Boris Dewitte, Boris Dewitte, Boris Dewitte, Orlando Astudillo, Lucas Glasner   +9 more
doaj   +1 more source