Results 81 to 90 of about 238,378 (313)

Particle transport across a channel via an oscillating potential

, 2017
Membrane protein transporters alternate their substrate-binding sites between the extracellular and cytosolic side of the membrane according to the alternating access mechanism.
J Gladrow (21873041), S Pagliara (21860231), L Dagdug (21873044), UF Keyser (21860243), Y Tan (6337964)   +4 more
core   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

On the role of onshore geostrophic flow on larval retention in a permanent upwelling zone along north-central Chile

Frontiers in Marine Science
The Humboldt Archipelago (HAp), located off north-central Chile (~28° - 33° S) is one of the most productive marine zones of the Humboldt Current System (HCS).
Eduardo A. Flores, Eduardo A. Flores, Marcel Ramos, Marcel Ramos, Marcel Ramos, Boris Dewitte, Boris Dewitte, Boris Dewitte, Orlando Astudillo, Lucas Glasner   +9 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Electrokinetic Particle Transport in Micro-Nanofluidics: Direct Numerical Simulation Analysis

, 2012
Numerous applications of micro-/nanofluidics are related to particle transport in micro-/nanoscale channels, and electrokinetics has proved to be one of the most promising tools to manipulate particles in micro/nanofluidics.
Qian, Shizhi, Ai, Ye
core  

Energetic particle acceleration and transport with the novel Icarus + PARADISE model

Journal of Space Weather and Space Climate
With the rise of satellites and mankind’s growing dependence on technology, there is an increasing awareness of space weather phenomena related to high-energy particles.
Husidic Edin, Wijsen Nicolas, Baratashvili Tinatin, Poedts Stefaan, Vainio Rami   +4 more
doaj   +1 more source

Particle transport processes [PDF]

Nature, 1980
Transport Theory. By J.J. Duderstadt and W.R. Martin. Pp.613. (Wiley: New York and Chichester, UK, 1979.) £24.
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

MULTI·DIMENSIONAL ANALYTICAL BENCHMARKS FOR NEUTRAL PARTICLE TRANSPORT

, 1995
Multi-dimensional analytical benchmarks for neutral particle ...
Kornreich, Drew Edward., Kornreich Drew Edward, Drew Edward Kornreich   +2 more
core