Results 81 to 90 of about 3,630,144 (297)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

On the role of onshore geostrophic flow on larval retention in a permanent upwelling zone along north-central Chile

Frontiers in Marine Science
The Humboldt Archipelago (HAp), located off north-central Chile (~28° - 33° S) is one of the most productive marine zones of the Humboldt Current System (HCS).
Eduardo A. Flores, Eduardo A. Flores, Marcel Ramos, Marcel Ramos, Marcel Ramos, Boris Dewitte, Boris Dewitte, Boris Dewitte, Orlando Astudillo, Lucas Glasner   +9 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Experimental evidence for increased particle fluxes due to a change in transport at the separatrix near density limits on Alcator C-Mod

Nuclear Fusion
Experimental inferences of cross-field particle flux at the separatrix, $\Gamma_{\perp}^\mathrm{sep}$ , show rapid growth near H-mode and L-mode density limits at high magnetic field on Alcator C-Mod.
M.A. Miller, J.W. Hughes, T. Eich, G.R. Tynan, P. Manz, A.E. Hubbard, B. LaBombard, J. Dunsmore   +7 more
doaj   +1 more source

Energetic particle acceleration and transport with the novel Icarus + PARADISE model

Journal of Space Weather and Space Climate
With the rise of satellites and mankind’s growing dependence on technology, there is an increasing awareness of space weather phenomena related to high-energy particles.
Husidic Edin, Wijsen Nicolas, Baratashvili Tinatin, Poedts Stefaan, Vainio Rami   +4 more
doaj   +1 more source

Particle transport processes [PDF]

Nature, 1980
Transport Theory. By J.J. Duderstadt and W.R. Martin. Pp.613. (Wiley: New York and Chichester, UK, 1979.) £24.
openaire   +1 more source

Transport outlook 2010: The potential for innovation [PDF]

, 2010
This paper provides evidence on and discussion of recent developments in global transport markets and analyzes what policies look most promising for stabilizing CO2-emissions from light-duty vehicles.
International Transport Forum, OECD
core   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Microplastic leaching effect on soil particle transport in macropores

This data set presents information on vertical microplastic leaching and soil particle transport in different macropore characteristics. The data is stored in file ESR11_41.csv, while metadata can be found in ESR11_41.pdf.This data set presents ...
Gómez Calero, José Alfonso, Maqbool, Ahsan, Soriano, Mª Auxiliadora, Li, Wang, Stumpp, Christine   +4 more
core   +1 more source