Results 81 to 90 of about 3,434,853 (290)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
3D Lagrangian Particle Tracking
, 2021 3D Lagrangian Particle Tracking (LPT) is an image-based flow measurement technique allowing to determine position, velocity and acceleration along a large number of particle tracks at high temporal resolution within the investigated volume.
Novara, Matteo +4 more
core
Energetic particle acceleration and transport with the novel Icarus + PARADISE model
Journal of Space Weather and Space ClimateWith the rise of satellites and mankind’s growing dependence on technology, there is an increasing awareness of space weather phenomena related to high-energy particles.
Husidic Edin +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
A Particle method for stationary transport equations
CoRRWe present and study a Particle method for the stationary solutions of a class of transport equations. This method is inspired by non-stationary Particle methods, the time variable being replaced by one spatial variable. Particles trajectories are computed using the ``time-dependent'' equations, and then the approximation is based on a quadrature ...
Rafael Bailo +3 more
openaire +5 more sources
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Yuanzineng kexue jishuThe research and development progress of NECP-MCX, a deep penetrating cross-scale radiation field analysis software independently developed by Xi'an Jiaotong University, is summarized.
WU Hongchun, HE Qingming, CAO Liangzhi, HUANG Zhanpeng, ZHENG Qi, LI Jie, QIN Shuai, HUANG Jinlong, BAO Yan
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source