Results 81 to 90 of about 223,851 (268)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Optimal conditions for indoor air purification using non-thermal Corona discharge electrostatic precipitator

Open Physics
Cold plasmas improve indoor air quality by reducing fine and ultrafine particles threatening human health. Electrostatic precipitator (ESP) uses non-thermal corona discharge connected to negative DC high voltage needles with grounded parallel plate ...
Elaissi Samira, Alsaif Norah A.M., Moneer Eman M., Gouadria Soumaya   +3 more
doaj   +1 more source

Simulation of the Particle Transport Behaviors in Nanoporous Matter. [PDF]

Polymers (Basel), 2022
Wu Y, Ju D, Wang H, Sun C, Wu Y, Cao Z, Tolochko OV.   +6 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Investigation of EDF evolution and charged particle transport in E × B plasma based negative ion sources using kinetic simulations. [PDF]

Sci Rep, 2023
Shah M, Chaudhury B, Bandyopadhyay M.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Study on evolution characteristics of coal fracture structure and fluid migration law under the action of water-loaded particles

Meikuang Anquan
The amorphous particles such as coal rock contained in the coal seam enter the fracture channel with the pressure water during the water injection process, which directly affects the structural characteristics of the fracture channel, and then changes ...
Zhongxiang GAO, Jing YANG, Houyuan GAO, He YANG, Jinrui HU, Shuyang SUN   +5 more
doaj   +1 more source

Large-scale flow field and aerosol particle transport investigations in a classroom using 2D-Shake-The-Box Lagrangian Particle Tracking. [PDF]

Heliyon, 2023
Buchwald T, Hasanuzzaman G, Merbold S, Schanz D, Egbers C, Schröder A.   +5 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Effect of gravity on colloidal particle transport in a saturated porous medium: Analytical solutions and experiments. [PDF]

PLoS One, 2022
Tu S, Liu X, Cai H.
europepmc   +1 more source