Results 61 to 70 of about 45,557 (210)

Increased Dendritic Branching of and Reduced δ-GABAA Receptor Expression on Parvalbumin-Positive Interneurons Increase Inhibitory Currents and Reduce Synaptic Plasticity at Puberty in Female Mouse CA1 Hippocampus

Frontiers in Cellular Neuroscience, 2020
Parvalbumin positive (PV+) interneurons play a pivotal role in cognition and are known to be regulated developmentally and by ovarian hormones. The onset of puberty represents the end of a period of optimal learning when impairments in synaptic ...
Hui Shen, Hui Shen, Lindsay Kenney, Lindsay Kenney, Sheryl S. Smith, Sheryl S. Smith   +5 more
doaj   +1 more source

Hippocampal network activity changes during early epileptogenesis predict subsequent epilepsy

Epilepsia, EarlyView.
Abstract Objective Despite decades of research, the circuit mechanisms that underlie focal epileptogenesis remain incompletely understood. In this study, we aimed to characterize the changes in hippocampal network activity induced by an epileptogenic insult.
Michael Strüber, Tristan Manfred Stöber, Vanessa Schütz, Lara Costard, Valentin Neubert, Sebastian Bauer, Parsa Gharavi, Julika Pitsch, Nico Melzer, Adam Strzelczyk, Jochen Triesch, Kai Siebenbrodt, Felix Rosenow, Ricardo Kienitz   +13 more
wiley   +1 more source

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Interneuron Development Is Disrupted in Preterm Brains With Diffuse White Matter Injury: Observations in Mouse and Human

Frontiers in Physiology, 2019
Preterm brain injury, occurring in approximately 30% of infants born <32 weeks gestational age, is associated with an increased risk of neurodevelopmental disorders, such as autism spectrum disorder (ASD) and attention deficit hyperactivity disorder ...
Helen B. Stolp, Helen B. Stolp, Bobbi Fleiss, Bobbi Fleiss, Bobbi Fleiss, Yoko Arai, Veena Supramaniam, Regina Vontell, Regina Vontell, Sebastian Birtles, Abi G. Yates, Abi G. Yates, Ana A. Baburamani, Claire Thornton, Claire Thornton, Mary Rutherford, A. David Edwards, Pierre Gressens, Pierre Gressens   +18 more
doaj   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Optimisation of an extraction technique of fish allergens suitable for detection and diagnosis

Czech Journal of Food Sciences, 2017
An optimised protocol for the extraction of allergenic proteins in fish was developed. Twelve existing or modified extraction buffers were evaluated based on the amount and quality of obtained 12 kDa IgG-binding protein (major fish allergen parvalbumin ...
Jiaju Ma, Tushar Ramesh Pavase, Zhen-Xing Li, Hong Lin   +3 more
doaj   +1 more source

Improved Post‐Processing Framework for Whole Slide Imaging and 3D Reconstruction

Microscopy Research and Technique, EarlyView.
Workflow for 3D reconstruction of marmoset whole‐slide histology. Individual tiles undergo vignette correction to address illumination artifacts before stitching into full‐section images. Sections are then reconstructed using the Possum framework, with a level‐set method incorporated at the nonlinear deformable stage to stabilize alignment and reduce ...
Emily L. De Leon Alvarado, Daryan Chitsaz, Ilana R. Leppert, Jennifer S. W. Campbell, Yangyingqi Zhou, G. Bruce Pike, Timothy E. Kennedy, Christine L. Tardif, Christopher D. Rowley   +8 more
wiley   +1 more source

Distribution Patterns of Three Molecularly Defined Classes of GABAergic Neurons Across Columnar Compartments in Mouse Barrel Cortex

Frontiers in Neuroanatomy, 2019
The mouse somatosensory cortex is an excellent model to study the structural basis of cortical information processing, since it possesses anatomically recognizable domains that receive different thalamic inputs, which indicates spatial segregation of ...
Zsuzsanna Almási, Csaba Dávid, Mirko Witte, Jochen F. Staiger   +3 more
doaj   +1 more source