Results 61 to 70 of about 46,693 (216)

Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice

Nature Communications
The hippocampus is the brain’s center for episodic memories. Its subregions, the dentate gyrus and CA1-3, are differentially involved in memory encoding and recall. Hippocampal principal cells represent episodic features like movement, space, and context,
Thomas Hainmueller, Aurore Cazala, Li-Wen Huang, Marlene Bartos   +3 more
doaj   +1 more source

Age-related neurochemical changes in the rhesus macaque inferior colliculus.

Frontiers in Aging Neuroscience, 2014
Age-related hearing loss (ARHL) is marked by audiometric hearing deficits that propagate along the auditory pathway. Neurochemical changes as a function of aging have also been identified in neurons along the auditory pathway in both rodents and ...
James eEngle, James eEngle, James eEngle, Daniel T Gray, Heather eTurner, Julia B Udell, Gregg H Recanzone   +6 more
doaj   +1 more source

Parvalbumin Neurons in Zona Incerta Regulate Itch in Mice

Frontiers in Molecular Neuroscience, 2022
Pain and itch are intricately entangled at both circuitry and behavioral levels. Emerging evidence indicates that parvalbumin (PV)-expressing neurons in zona incerta (ZI) are critical for promoting nocifensive behaviors.
Jiaqi Li, Yang Bai, Yi Liang, Yiwen Zhang, Qiuying Zhao, Junye Ge, Dangchao Li, Yuanyuan Zhu, Guohong Cai, Huiren Tao, Shengxi Wu, Jing Huang   +11 more
doaj   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Cell-type-specific control of basolateral amygdala neuronal circuits via entorhinal cortex-driven feedforward inhibition

eLife, 2020
The basolateral amygdala (BLA) plays a vital role in associating sensory stimuli with salient valence information. Excitatory principal neurons (PNs) undergo plastic changes to encode this association; however, local BLA inhibitory interneurons (INs ...
E Mae Guthman, Joshua D Garcia, Ming Ma, Philip Chu, Serapio M Baca, Katharine R Smith, Diego Restrepo, Molly M Huntsman   +7 more
doaj   +1 more source

Effects of Maternal Deprivation on the Prefrontal Cortex of Male Rats: Cellular, Neurochemical, and Behavioral Outcomes

Frontiers in Behavioral Neuroscience, 2021
Stressful events experienced during early life are associated with increased vulnerability of developing psychopathology in adulthood. In the present study, we exposed 9-day-old Wistar rats to 24 h maternal deprivation (MD) with the aim to investigate ...
Joko Poleksic, Milan Aksic, Slobodan Kapor, Dubravka Aleksic, Tihomir Stojkovic, Marina Radovic, Vuk Djulejic, Branka Markovic, Antonios Stamatakis   +8 more
doaj   +1 more source

Cortical Thickness and White Matter Surface Morphology in Tourette Syndrome: A Cohort Study

Annals of Neurology, EarlyView.
Objective To examine cortical thickness and white matter surface morphology in a large sample of individuals with Tourette syndrome (TS) and neurotypical controls across the lifespan, and to assess associations with symptom severity, comorbidities, and medication use.
Sahar Delavari, Adam C. Frank, Ravi Bansal, Flora M. Vaccarino, Robert A. King, Paul Lombroso, Lawrence Scahill, James F. Leckman, Bradley S. Peterson   +8 more
wiley   +1 more source

T Cell‐Mediated Targeting of Interneurons in Mice Shapes Hippocampal Remodeling and Epilepsy

Annals of Neurology, EarlyView.
Objective Autoimmune encephalitis (AE) is associated with autoantibodies targeting distinct neuronal populations. In AE, antibodies against glutamate decarboxylase 65 (GAD65), expressed in GABAergic interneurons, are frequently detected. In GAD65‐AE, hippocampal biopsies often show infiltrates of CD8+ cytotoxic T cells (CTLs), suggesting a prominent T ...
Daniel S. Galvis‐Montes, Lukas Henning, Karen M. J. van Loo, Rainer Surges, Susanne Schoch, Albert J. Becker, Julika Pitsch   +6 more
wiley   +1 more source

Increased Dendritic Branching of and Reduced δ-GABAA Receptor Expression on Parvalbumin-Positive Interneurons Increase Inhibitory Currents and Reduce Synaptic Plasticity at Puberty in Female Mouse CA1 Hippocampus

Frontiers in Cellular Neuroscience, 2020
Parvalbumin positive (PV+) interneurons play a pivotal role in cognition and are known to be regulated developmentally and by ovarian hormones. The onset of puberty represents the end of a period of optimal learning when impairments in synaptic ...
Hui Shen, Hui Shen, Lindsay Kenney, Lindsay Kenney, Sheryl S. Smith, Sheryl S. Smith   +5 more
doaj   +1 more source

Comparative analysis of cytoarchitectonic and neurochemical aspects of the globus pallidus in the rock cavy (Kerodon rupestris) and the common marmoset (Callithrix jacchus)

The Anatomical Record, EarlyView.
Abstract The globus pallidus (GP), a subcortical structure within the basal ganglia, plays a crucial role in modulating cortico‐subcortical circuits related to motor control and associative/limbic functions. However, the cytoarchitectonic and neurochemical organization of this structure remains poorly characterized in naturally existing wild‐type ...
Lavínnya Yáskara de Aquino Matoso, Yasmin Pinto Fernandes Albuquerque, Karina Maia Paiva, Rodrigo Freire Oliveira, Nelyane Nayara Martins de Santana, Expedito Silva do Nascimento‐Júnior, Rovena Clara G. J. Engelberth, Jeferson de Souza Cavalcante, Adhil Bhagwandin, Paulo Leonardo Araújo de Góis Morais, José Rodolfo Lopes de Paiva Cavalcanti   +10 more
wiley   +1 more source