Results 41 to 50 of about 71,563 (292)

Compulsive Social Behavior Emerges after Selective Ablation of Striatal Cholinergic Interneurons [PDF]

, 2017
The mechanisms underlying social dysfunction in neuropsychiatric conditions like obsessive-compulsive disorder (OCD) and Tourette syndrome (TS) remain uncertain. Dysfunctions in basal ganglia, including reduced number of striatal cholinergic interneurons
Beccaria, Juan Pablo, Belforte, Juan Emilio, Braz, Bárbara Yael, Martos Schott, Yanina Victoria, Murer, Mario Gustavo   +4 more
core   +1 more source

Developmental Expression of Calcium-Binding Protein-Containing Neurons in Neocortical Transplants

Cell Transplantation, 1998
The present study examined the development of calcium binding protein-containing neurons in a timed series of fetal neocortical transplants. The immunoexpression of parvalbumin and calbindin, which are subpopulations of GABAergic neurons, have been ...
Jeffrey M. Rosenstein, Newton S. More, Nina Mani, Janette M. Krum   +3 more
doaj   +1 more source

State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex. [PDF]

, 2019
Brain state determines patterns of spiking output that underlie behavior. In neocortex, brain state is reflected in the spontaneous activity of the network, which is regulated in part by neuromodulatory input from the brain stem and by local inhibition ...
Garcia-Junco-Clemente, Pablo, Ringach, Dario L, Trachtenberg, Joshua T, Tring, Elaine   +3 more
core   +1 more source

Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism [PDF]

Molecular Brain, 2016
A reduction of the number of parvalbumin (PV)-immunoreactive (PV(+)) GABAergic interneurons or a decrease in PV immunoreactivity was reported in several mouse models of autism spectrum disorders (ASD). This includes Shank mutant mice, with SHANK being one of the most important gene families mutated in human ASD.
Filice, Federica, Voerckel, Karl Jakob, Sungur, Ayse Oezge, Woehr, Markus, Schwaller, Beat   +4 more
openaire   +5 more sources

Social Stimulus Causes Aberrant Activation of the Medial Prefrontal Cortex in a Mouse Model With Autism-Like Behaviors

Frontiers in Synaptic Neuroscience, 2018
Autism spectrum disorder (ASD) is a highly prevalent and genetically heterogeneous brain disorder. Developing effective therapeutic interventions requires knowledge of the brain regions that malfunction and how they malfunction during ASD-relevant ...
Antonella Pirone, Jonathan M. Alexander, Jenny B. Koenig, Denise R. Cook-Snyder, Medha Palnati, Robert J. Wickham, Lillian Eden, Neha Shrestha, Leon Reijmers, Thomas Biederer, Klaus A. Miczek, Chris G. Dulla, Michele H. Jacob   +12 more
doaj   +1 more source

Eliminating the VGlut2-Dependent Glutamatergic Transmission of Parvalbumin-Expressing Neurons Leads to Deficits in Locomotion and Vocalization, Decreased Pain Sensitivity, and Increased Dominance

Frontiers in Behavioral Neuroscience, 2018
The calcium-binding protein parvalbumin (PV) is a recognized marker of short-axon GABA-ergic neurons in the cortex and the hippocampus. However in addition, PV is expressed by excitatory, glutamatergic neurons in various areas of the brain and spinal ...
Diana M. Roccaro-Waldmeyer, Franck Girard, Daniele Milani, Elisabetta Vannoni, Laurent Prétôt, David P. Wolfer, David P. Wolfer, David P. Wolfer, Marco R. Celio   +8 more
doaj   +1 more source

Peroxisome proliferator-activated receptor alpha plays a crucial role in behavioral repetition and cognitive flexibility in mice [PDF]

, 2015
Acknowledgments We thank Luca Giordano, Giovanni Esposito and Angelo Russo for technical assistance and Dr. Livio Luongo (Second University of Naples–Italy) for critical discussions.
Avagliano, Carmen, Calignano, Antonio, Citraro, Rita, Cristiano, Claudia, D'Agostino, Giuseppe, De Sarro, Giovambattista, Heisler, Lora K, Lyons, David J, Meli, Rosaria, Raso, Giuseppina Mattace, Russo, Emilio, Russo, Roberto   +11 more
core   +2 more sources

Gradient of Parvalbumin- and Somatostatin-Expressing Interneurons Across Cingulate Cortex Is Differentially Linked to Aggression and Sociability in BALB/cJ Mice

Frontiers in Psychiatry, 2019
Successfully navigating social interactions requires the precise and balanced integration of social and environmental cues. When such flexible information integration fails, maladaptive behavioral patterns arise, including excessive aggression, empathy ...
Sabrina van Heukelum, Floriana Mogavero, Melissa A.E. van de Wal, Femke E. Geers, Arthur S.C. França, Jan K. Buitelaar, Christian F. Beckmann, Jeffrey C. Glennon, Martha N. Havenith   +8 more
doaj   +1 more source

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain. [PDF]

, 2015
© 2015 The Authors.Objective: Although Glucagon-like peptide 1 is a key regulator of energy metabolism and food intake, the precise location of GLP-1 receptors and the physiological relevance of certain populations is debatable.
Cork, SC, Gribble, FM, Holt, MK, Reimann, F, Richards, JE, Trapp, S   +5 more
core   +2 more sources

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source