Results 21 to 30 of about 51,758 (256)

Tau Knockout and α-Synuclein A53T Synergy Modulated Parvalbumin-Positive Neurons Degeneration Staging in Substantia Nigra Pars Reticulata of Parkinson’s Disease-Liked Model

Frontiers in Aging Neuroscience, 2022
The loss of parvalbumin-positive (PV+) neurons in the substantia nigra pars reticulata (SNR) was observed in patients with end-stage Parkinson’s disease (PD) and our previously constructed old-aged Pitx3-A53Tα-Syn × Tau–/– triple transgenic mice model of
Meige Zheng, Yanchang Liu, Zhaoming Xiao, Luyan Jiao, Xian Lin, Xian Lin   +5 more
doaj   +1 more source

Engineering parvalbumin for the heart: optimizing the Mg2+ binding properties of rat β-parvalbumin [PDF]

Frontiers in Physiology, 2011
Parvalbumin (PV), an EF-hand protein family member, is a delayed calcium buffer that exchanges magnesium for calcium to facilitate fast skeletal muscle relaxation. Genetic approaches that express parvalbumin in the heart also enhance relaxation and show promise of being therapeutic against various cardiac diseases where relaxation is compromised ...
Zhang, Jianchao, Shettigar, Vikram, Zhang, George C., Kindell, Daniel G., Liu, Xiaotong, López, Joseph J., Yerrimuni, Vinatham, Davis, Grace A., Davis, Jonathan P.   +8 more
openaire   +2 more sources

Aberrant location of inhibitory synaptic marker proteins in the hippocampus of dystrophin-deficient mice [PDF]

, 2014
Duchenne muscular dystrophy (DMD) is a neuromuscular disease that arises from mutations in the dystrophin-encoding gene. Apart from muscle pathology, cognitive impairment, primarily of developmental origin, is also a significant component of the disorder.
Zablocki, Krzysztof, Elżbieta Krasowska, Krasowska Elżbieta, Gorecki, Dariusz C., Swinny, Jerome D., Dariusz C Górecki, Swinny Jerome D., Zabłocki Krzysztof, Jerome D Swinny, Krasowska, Elzbieta, Górecki Dariusz C., Krzysztof Zabłocki   +11 more
core   +1 more source

Long-term alterations of striatal parvalbumin interneurons in a rat model of early exposure to alcohol

Journal of Neurodevelopmental Disorders, 2012
Background Exposure to alcohol in utero is a known cause of mental retardation. Although a certain degree of motor impairment is always associated with fetal alcohol spectrum disorder, little is known about the neurobiological basis of the defective ...
De Giorgio Andrea, Comparini Sara E, Intra Francesca, Granato Alberto   +3 more
doaj   +1 more source

Sex Differences in Affective Dysfunction and Alterations in Parvalbumin in Rodent Models of Early Life Adversity

Frontiers in Behavioral Neuroscience, 2021
The early life environment markedly influences brain and behavioral development, with adverse experiences associated with increased risk of anxiety and depressive phenotypes, particularly in females.
Seneca N. Ellis, Jennifer A. Honeycutt, Jennifer A. Honeycutt   +2 more
doaj   +1 more source

Regulation of the E/I-balance by the neural matrisome

Frontiers in Molecular Neuroscience, 2023
In the mammalian cortex a proper excitatory/inhibitory (E/I) balance is fundamental for cognitive functions. Especially γ-aminobutyric acid (GABA)-releasing interneurons regulate the activity of excitatory projection neurons which form the second main ...
Cornelius Mueller-Buehl, David Wegrzyn, Juliane Bauch, Andreas Faissner   +3 more
doaj   +1 more source

Oncomodulin: The Enigmatic Parvalbumin Protein [PDF]

Frontiers in Molecular Neuroscience, 2019
EF-hand Ca2+-binding protein family members, α- and β-parvalbumins have been studied for decades. Yet, considerable information is lacking distinguishing functional differences between mammalian α-parvalbumin (PVALB) and oncomodulin (OCM), a branded β-parvalbumin.
Leslie K. Climer, Leslie K. Climer, Andrew M. Cox, Andrew M. Cox, Timothy J. Reynolds, Dwayne D. Simmons, Dwayne D. Simmons, Dwayne D. Simmons   +7 more
openaire   +3 more sources

Circadian-Related Serotonin/Melatonin Level Modulates Cisplatin Ototoxicity Susceptibility Depended on NOS3-NO Pathway. [PDF]

J Pineal Res
ABSTRACT Hearing impairment is attributed to factors such as age, genetic predisposition, and environmental influences, among which environmental factors are considered modifiable. Among various environmental factors, the role of poor lifestyle habits is particularly critical, yet the specific mechanisms by which they contribute to hearing damage ...
Qiu S, Cai S, Xie R, Liu C, He Y.
europepmc   +2 more sources

Upregulated expression of oncomodulin, the beta isoform of parvalbumin, in perikarya and axons in the diencephalon of parvalbumin knockout mice [PDF]

, 2010
The calcium-binding proteins parvalbumin, calbindin D-28k, calretinin and calcineurin are present in subsets of GABAergic gigantic calyciform presynaptic terminals of the reticular thalamic nucleus (RTN).
Knyihár-Csillik Erzsébet, Csillik, B., Csillik Bertalan, Losonczi, E., Schwaller, Beat, Knyihar-Csillik, E., Mihaly, A., Losonczi Erika, Schwaller B., Mihály András, Henzi T., Henzi, Thomas   +11 more
core   +1 more source

Calretinin as a marker for premotor neurons involved in upgaze in human brainstem

Frontiers in Neuroanatomy, 2015
Eye movements are generated by different premotor pathways. Damage to them can cause specific deficits of eye movements, such as saccades. For correlative clinico-anatomical post-mortem studies of cases with eye movement disorders it is essential to ...
Christopher eAdamczyk, Michael eStrupp, Michael eStrupp, Klaus eJahn, Klaus eJahn, Anja Kerstin Ellen Horn, Anja Kerstin Ellen Horn   +6 more
doaj   +1 more source