Results 31 to 40 of about 51,758 (256)

Altered Relationship Between Parvalbumin and Perineuronal Nets in an Autism Model

Frontiers in Molecular Neuroscience, 2021
Altered function or presence of inhibitory neurons is documented in autism spectrum disorders (ASD), but the mechanism underlying this alternation is poorly understood.
Dan Xia, Dan Xia, Li Li, Binrang Yang, Qiang Zhou   +4 more
doaj   +1 more source

Anxious Profile Influences Behavioral and Immunohistological Findings in the Pilocarpine Model of Epilepsy

Frontiers in Pharmacology, 2021
Anxiety and epilepsy have a complex bidirectional relationship, where a depressive/anxious condition is a factor that can trigger seizures which in turn can aggravate the depressive/anxious condition. In addition, brain structures such as the hippocampus
Silvia Regina Bica Kohek, Maira Licia Foresti, Miriam Marcela Blanco, Clarissa Fantin Cavarsan, Clarissa Fantin Cavarsan, Clivandir Severino da Silva, Luiz E. Mello, Luiz E. Mello   +7 more
doaj   +1 more source

Parvalbumin neurons in the forebrain as revealed by parvalbumin-Cre transgenic mice

Neuroscience Research, 2009
Neurons expressing the calcium-binding protein parvalbumin (PV) constitute an abundant subpopulation of GABAergic neurons in the cerebral cortex. However, PV is not unique to the GABAergic neurons of the forebrain, but is also expressed in a small number of pyramidal neurons and in a large number of thalamic neurons.
Chiyoko, Tanahira, Shigeyoshi, Higo, Keisuke, Watanabe, Ryohei, Tomioka, Satoe, Ebihara, Takeshi, Kaneko, Nobuaki, Tamamaki   +6 more
openaire   +2 more sources

Postnatal development of thalamic reticular nucleus projections to the anterior thalamic nuclei in rats

European Journal of Histochemistry, 2022
The thalamic reticular nucleus (TRN) projects inhibitory signals to the thalamus, thereby controlling thalamocortical connections. Few studies have examined the development of TRN projections to the anterior thalamic nuclei with regard to axon course ...
Hitoshi Fujita, Kosuke Imura, Masahito Takiguchi, Kengo Funakoshi   +3 more
doaj   +1 more source

Altered Disrupted-in-Schizophrenia-1 Function Affects the Development of Cortical Parvalbumin Interneurons by an Indirect Mechanism.

PLoS ONE, 2016
Disrupted-in-Schizophrenia-1 (DISC1) gene has been linked to schizophrenia and related major mental illness. Mouse Disc1 has been implicated in brain development, mainly in the proliferation, differentiation, lamination, neurite outgrowth and synapse ...
Malgorzata Borkowska, J Kirsty Millar, David J Price   +2 more
doaj   +1 more source

Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism [PDF]

Molecular Brain, 2016
A reduction of the number of parvalbumin (PV)-immunoreactive (PV(+)) GABAergic interneurons or a decrease in PV immunoreactivity was reported in several mouse models of autism spectrum disorders (ASD). This includes Shank mutant mice, with SHANK being one of the most important gene families mutated in human ASD.
Filice, Federica, Voerckel, Karl Jakob, Sungur, Ayse Oezge, Woehr, Markus, Schwaller, Beat   +4 more
openaire   +5 more sources

The distribution of N-acetylgalactosamine in the cochlear nucleus of the gerbil revealed by lectin binding with soybean agglutinin

, 1994
A horseradish peroxidase conjugated lectin from Glycine max (soy bean agglutinin; SBA) was used to characterise the distribution of N-acetylgalactosamine in the cochlear nucleus of the mongolian gerbil. SBA bound differentially to a variety of structures
Gleich, Otto
core   +1 more source

Developmental Expression of Calcium-Binding Protein-Containing Neurons in Neocortical Transplants

Cell Transplantation, 1998
The present study examined the development of calcium binding protein-containing neurons in a timed series of fetal neocortical transplants. The immunoexpression of parvalbumin and calbindin, which are subpopulations of GABAergic neurons, have been ...
Jeffrey M. Rosenstein, Newton S. More, Nina Mani, Janette M. Krum   +3 more
doaj   +1 more source

Social Stimulus Causes Aberrant Activation of the Medial Prefrontal Cortex in a Mouse Model With Autism-Like Behaviors

Frontiers in Synaptic Neuroscience, 2018
Autism spectrum disorder (ASD) is a highly prevalent and genetically heterogeneous brain disorder. Developing effective therapeutic interventions requires knowledge of the brain regions that malfunction and how they malfunction during ASD-relevant ...
Antonella Pirone, Jonathan M. Alexander, Jenny B. Koenig, Denise R. Cook-Snyder, Medha Palnati, Robert J. Wickham, Lillian Eden, Neha Shrestha, Leon Reijmers, Thomas Biederer, Klaus A. Miczek, Chris G. Dulla, Michele H. Jacob   +12 more
doaj   +1 more source

Eliminating the VGlut2-Dependent Glutamatergic Transmission of Parvalbumin-Expressing Neurons Leads to Deficits in Locomotion and Vocalization, Decreased Pain Sensitivity, and Increased Dominance

Frontiers in Behavioral Neuroscience, 2018
The calcium-binding protein parvalbumin (PV) is a recognized marker of short-axon GABA-ergic neurons in the cortex and the hippocampus. However in addition, PV is expressed by excitatory, glutamatergic neurons in various areas of the brain and spinal ...
Diana M. Roccaro-Waldmeyer, Franck Girard, Daniele Milani, Elisabetta Vannoni, Laurent Prétôt, David P. Wolfer, David P. Wolfer, David P. Wolfer, Marco R. Celio   +8 more
doaj   +1 more source