Results 31 to 40 of about 45,557 (210)

Eliminating the VGlut2-Dependent Glutamatergic Transmission of Parvalbumin-Expressing Neurons Leads to Deficits in Locomotion and Vocalization, Decreased Pain Sensitivity, and Increased Dominance

Frontiers in Behavioral Neuroscience, 2018
The calcium-binding protein parvalbumin (PV) is a recognized marker of short-axon GABA-ergic neurons in the cortex and the hippocampus. However in addition, PV is expressed by excitatory, glutamatergic neurons in various areas of the brain and spinal ...
Diana M. Roccaro-Waldmeyer, Franck Girard, Daniele Milani, Elisabetta Vannoni, Laurent Prétôt, David P. Wolfer, David P. Wolfer, David P. Wolfer, Marco R. Celio   +8 more
doaj   +1 more source

Gradient of Parvalbumin- and Somatostatin-Expressing Interneurons Across Cingulate Cortex Is Differentially Linked to Aggression and Sociability in BALB/cJ Mice

Frontiers in Psychiatry, 2019
Successfully navigating social interactions requires the precise and balanced integration of social and environmental cues. When such flexible information integration fails, maladaptive behavioral patterns arise, including excessive aggression, empathy ...
Sabrina van Heukelum, Floriana Mogavero, Melissa A.E. van de Wal, Femke E. Geers, Arthur S.C. França, Jan K. Buitelaar, Christian F. Beckmann, Jeffrey C. Glennon, Martha N. Havenith   +8 more
doaj   +1 more source

Cell-type-specific modulation of neocortical activity by basal forebrain Input

Frontiers in Systems Neuroscience, 2013
Activation of the cholinergic neurons in the basal forebrain (BF) desynchronizes cortical activity and enhances sensory processing during arousal and attention.
Henry J Alitto, Henry J Alitto, Henry J Alitto, Yang eDan, Yang eDan, Yang eDan   +5 more
doaj   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Regional and sub-regional differences in hippocampal GABAergic neuronal vulnerability in the TgCRND8 mouse model of Alzheimer’s disease

Frontiers in Aging Neuroscience, 2015
Hippocampal network activity is predominantly coordinated by -amino-butyric acid (GABA)ergic neurons. We have previously hypothesized that the altered excitability of hippocampal neurons in Alzheimer's disease (AD), which manifests as increased in vivo ...
Marilia Silva Albequerque, Marilia Silva Albequerque, Marilia Silva Albequerque, Marilia Silva Albequerque, Ian eMahar, Ian eMahar, Ian eMahar, Maria Antonietta eDavoli, Maria Antonietta eDavoli, Jean-Guy eChabot, Jean-Guy eChabot, Naguib eMechawar, Naguib eMechawar, Naguib eMechawar, Naguib eMechawar, Rémi eQuirion, Rémi eQuirion, Slavica eKrantic, Slavica eKrantic, Slavica eKrantic, Slavica eKrantic   +20 more
doaj   +1 more source

Cysteine Redox State Governs the Condensation Pathway of Hendra Virus W Protein and Differentially Impacts Type I IFN and NF‐κB Signaling

Advanced Science, EarlyView.
The cysteine redox state of the Hendra virus W (WHeV) protein controls assembly into fibrils or amorphous aggregates, with residues 2–29 required for fibrillation. In cells, WHeV forms different types of nuclear condensates. Impaired ability to form redox‐sensitive, non‐filamentous condensates reduces WHeV inhibition of the NF‐κB pathway, while it ...
Frank Gondelaud, Alexandre Lalande, Giulia Pesce, Auriane Bouchet, Carole Meunier, Christophe Bignon, Denis Ptchelkine, Yu Gu, Eva Ogire, Pierre‐Yves Lozach, Denis Gerlier, Cyrille Mathieu, Sonia Longhi   +12 more
wiley   +1 more source

Molecular Specialization of GABAergic Synapses on the Soma and Axon in Cortical and Hippocampal Circuit Function and Dysfunction

Frontiers in Molecular Neuroscience, 2019
The diversity of inhibitory interneurons allows for the coordination and modulation of excitatory principal cell firing. Interneurons that release GABA (γ-aminobutyric acid) onto the soma and axon exert powerful control by virtue of proximity to the site
April Contreras, Dustin J. Hines, Rochelle M. Hines   +2 more
doaj   +1 more source

Multiscale Circuit Architecture Associated With Memory Dysfunction in Temporal Lobe Epilepsy

Advanced Science, EarlyView.
A multiscale precision‐mapping framework reveals that memory impairment in temporal lobe epilepsy arises from the convergence of focal medial temporal pathology, strategic white matter disconnection, and limbic‐centered metabolic network dysfunction.
Jiajie Mo, Qiwen Yuan, Pengfei Zhang, Lin Sang, Zhong Zheng, Baotian Zhao, Xiu Wang, Chao Zhang, Wenhan Hu, Xiaoqiu Shao, Jianguo Zhang, Ruijin Yang, Kai Zhang   +12 more
wiley   +1 more source

High-pressure processing (HPP) impacts on indian mackerel meat: insights into quality attributes, β-parvalbumin antigenicity, and proteomic changes

Applied Food Research
High-pressure processing (HPP) is a non-thermal method that uses high hydrostatic pressure on food products to improve quality and shelf life. However, it can cause structural changes in proteins that alter food characteristics.
Marcella Meia Gary Enchangan, Muhammad Syamil Seman, Jameel R. Al-Obaidi, Atiqah Farah Zakaria, Ahmad Faizal Abdull Razis, Nazamid Saari, Hanis Hazeera Harith, Nuzul Noorahya Jambari   +7 more
doaj   +1 more source

Parvalbumin-Deficiency Accelerates the Age-Dependent ROS Production in Pvalb Neurons in vivo: Link to Neurodevelopmental Disorders

Frontiers in Cellular Neuroscience, 2020
In neurodevelopmental disorders (NDDs) including autism spectrum disorder (ASD) and schizophrenia, impairment/malfunctioning of a subpopulation of interneurons expressing the calcium-binding protein parvalbumin (PV) –here termed Pvalb neurons– has ...
Lucia Janickova, Beat Schwaller
doaj   +1 more source