Results 51 to 60 of about 71,563 (292)

Cell-type-specific modulation of neocortical activity by basal forebrain Input

Frontiers in Systems Neuroscience, 2013
Activation of the cholinergic neurons in the basal forebrain (BF) desynchronizes cortical activity and enhances sensory processing during arousal and attention.
Henry J Alitto, Henry J Alitto, Henry J Alitto, Yang eDan, Yang eDan, Yang eDan   +5 more
doaj   +1 more source

GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models. [PDF]

, 2020
NMDA receptors (NMDARs) play subunit-specific roles in synaptic function and are implicated in neuropsychiatric and neurodegenerative disorders. However, the in vivo consequences and therapeutic potential of pharmacologically enhancing NMDAR function via
Chan, Connie, Chen, Yelin, Deshmukh, Gauri, Elstrott, Justin, Gill, T Michael, Hackos, David H, Hanson, Jesse E, Jiang, Zhiyu, Khan, Abdullah S, Kim, Thomas A, Liederer, Bianca M, Liu, Benjamin, Ma, Keran, Palop, Jorge J, Saillet, Sandrine, Scearce-Levie, Kimberly, Schwarz, Jacob B, Sellers, Benjamin D, Sheng, Morgan, Simms, Jeffrey, Solanoy, Hilda, Volgraf, Matthew, Wang, Tzu-Ming, Weber, Martin, Weimer, Robby M, Yu, Gui-Qiu   +25 more
core   +1 more source

On the importance of including both sexes in animal studies – insights from home‐cage monitoring

Biological Reviews, EarlyView.
ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater, Adam Dušek, Aleksandra Bartelik, Silvia Mandillo, Elisabetta Golini, Mara Rigamonti, Rasneer Sonia Bains, Hamish Forrest, Marion Rivalan, Melissa Long, Anna Kiryk, Lars Lewejohann, Nuno Henrique Franco   +12 more
wiley   +1 more source

Regional and sub-regional differences in hippocampal GABAergic neuronal vulnerability in the TgCRND8 mouse model of Alzheimer’s disease

Frontiers in Aging Neuroscience, 2015
Hippocampal network activity is predominantly coordinated by -amino-butyric acid (GABA)ergic neurons. We have previously hypothesized that the altered excitability of hippocampal neurons in Alzheimer's disease (AD), which manifests as increased in vivo ...
Marilia Silva Albequerque, Marilia Silva Albequerque, Marilia Silva Albequerque, Marilia Silva Albequerque, Ian eMahar, Ian eMahar, Ian eMahar, Maria Antonietta eDavoli, Maria Antonietta eDavoli, Jean-Guy eChabot, Jean-Guy eChabot, Naguib eMechawar, Naguib eMechawar, Naguib eMechawar, Naguib eMechawar, Rémi eQuirion, Rémi eQuirion, Slavica eKrantic, Slavica eKrantic, Slavica eKrantic, Slavica eKrantic   +20 more
doaj   +1 more source

Voxel-wise comparisons of cellular microstructure and diffusion-MRI in mouse hippocampus using 3D Bridging of Optically-clear histology with Neuroimaging Data (3D-BOND) [PDF]

, 2018
A key challenge in medical imaging is determining a precise correspondence between image properties and tissue microstructure. This comparison is hindered by disparate scales and resolutions between medical imaging and histology.
Ball, G, Edwards, A D, Jones, M, So, P-W, Stolp, H B, Thornton, C, Tournier, J-D   +6 more
core   +6 more sources

The segregation of Calb1, Calb2, and Prph neurons reveals distinct and mixed neuronal populations and projections to hair cells in the inner ear and central nuclei

Developmental Dynamics, EarlyView.
Three populations of hair cells have a distinct expression of Calb1 and Calb2. (A, A′D) The central is highly positive for Calb1 while surrounding HC are positive for Calb2. Later, a calyx forms primarily with Calb1. (B, B′, D′, D″) Saccule and utricle start out positive for Calb2 but will upregulate the Calb1 in the striola that is primarily forming ...
Jeong Han Lee, Ebenezer N. Yamoah, Jennifer Kersigo, Karen Elliott, Niya LaRoda, Gabriela Pavlinkova, Bernd Fritzsch   +6 more
wiley   +1 more source

High-pressure processing (HPP) impacts on indian mackerel meat: insights into quality attributes, β-parvalbumin antigenicity, and proteomic changes

Applied Food Research
High-pressure processing (HPP) is a non-thermal method that uses high hydrostatic pressure on food products to improve quality and shelf life. However, it can cause structural changes in proteins that alter food characteristics.
Marcella Meia Gary Enchangan, Muhammad Syamil Seman, Jameel R. Al-Obaidi, Atiqah Farah Zakaria, Ahmad Faizal Abdull Razis, Nazamid Saari, Hanis Hazeera Harith, Nuzul Noorahya Jambari   +7 more
doaj   +1 more source

Molecular Specialization of GABAergic Synapses on the Soma and Axon in Cortical and Hippocampal Circuit Function and Dysfunction

Frontiers in Molecular Neuroscience, 2019
The diversity of inhibitory interneurons allows for the coordination and modulation of excitatory principal cell firing. Interneurons that release GABA (γ-aminobutyric acid) onto the soma and axon exert powerful control by virtue of proximity to the site
April Contreras, Dustin J. Hines, Rochelle M. Hines   +2 more
doaj   +1 more source

Decoding epilepsy's molecular blueprint: Machine learning unravels transcriptomic subtypes and regulatory networks

Epilepsia, EarlyView.
Abstract Objective Drug‐resistant epilepsy (DRE) affects approximately one‐third of patients with epilepsy. The molecular heterogeneity underlying DRE remains poorly defined, largely due to limited access to resected brain tissue and substantial genetic diversity.
Yanping Weng, Yu Ma, Wanwan Hou, Haibo Li, Yuanfeng Zhou, Rui Zhao, Hao Li, Lian Chen, Yangyang Ma, Li Jin, Yi Wang, Yu An   +11 more
wiley   +1 more source

Post-mortem human brain analysis of the ventral pallidum in alcohol use disorder

Addiction Neuroscience
Objective: Alcohol use disorder (AUD) is characterised by cycles of alcohol misuse, abstinence, and relapse. The neurobiology of AUD strongly implicates the role of the ventral pallidum (VP) in a variety of drugs of abuse, including alcohol. Pre-clinical
Ameer Elena Rasool, Cormac Peat, Jie Liu, Greg Sutherland, Asheeta A. Prasad   +4 more
doaj   +1 more source