Results 51 to 60 of about 46,693 (216)

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Molecular compartmentalization of lateral geniculate nucleus in the gray squirrel (Sciurus carolinensis)

Frontiers in Neuroanatomy, 2012
Previous research has suggested that the three physiologically-defined relay cell types in mammalian lateral geniculate nucleus (LGN) – called parvocellular (P), magnocellular (M), and koniocellular (K) cells in primates and X, Y, and W cells in other ...
Daniel L Felch, Stephen D Van Hooser
doaj   +1 more source

Functional and Molecular Analysis of Proprioceptive Sensory Neuron Excitability in Mice

Frontiers in Molecular Neuroscience, 2020
Neurons located in dorsal root ganglia (DRG) are crucial for transmitting peripheral sensations such as proprioception, touch, temperature, and nociception to the spinal cord before propagating these signals to higher brain structures.
Jessica F. Madden, Jessica F. Madden, Olivia C. Davis, Kieran A. Boyle, Jacqueline A. Iredale, Jacqueline A. Iredale, Tyler J. Browne, Tyler J. Browne, Robert J. Callister, Robert J. Callister, Douglas W. Smith, Douglas W. Smith, Phillip Jobling, Phillip Jobling, David I. Hughes, Brett A. Graham, Brett A. Graham   +16 more
doaj   +1 more source

Adaptive Network Stabilization Despite Profound Structural Reorganization in Human Organotypic Cultures

Advanced Science, EarlyView.
Adult human organotypic cortical slices undergo marked neuronal loss, laminar disruption, and glial activation, yet their network activity progressively stabilizes after a variable period. Electrophysiology, longitudinal calcium imaging, and quantitative histology show that structurally remodeled human circuits show adaptive capacity resulting in ...
Estilla Zsófia Tóth, Rebeka Stelcz, Réka Bod, Ábel Petik, Eszter Juhász, Kinga Tóth, Liza Szalai, Nour Essam, Fanni Somogyi, Beatrix Kovács, Amirmahdi Mojtahedzadeh, Attila György Bagó, Loránd Erőss, Péter Orbay, Johanna Petra Szabó, Dániel Fabó, Boglárka Hajnal, Bence Rácz, Daniel Hillier, István Ulbert, Lucia Wittner   +20 more
wiley   +1 more source

The Parvalbumin Hypothesis of Autism Spectrum Disorder [PDF]

Frontiers in Cellular Neuroscience, 2020
The prevalence of autism spectrum disorder (ASD)—a type of neurodevelopmental disorder—is increasing and is around 2% in North America, Asia, and Europe. Besides the known genetic link, environmental, epigenetic, and metabolic factors have been implicated in ASD etiology.
Federica Filice, Lucia Janickova, Thomas Henzi, Alessandro Bilella, Beat Schwaller   +4 more
openaire   +3 more sources

Post-mortem human brain analysis of the ventral pallidum in alcohol use disorder

Addiction Neuroscience
Objective: Alcohol use disorder (AUD) is characterised by cycles of alcohol misuse, abstinence, and relapse. The neurobiology of AUD strongly implicates the role of the ventral pallidum (VP) in a variety of drugs of abuse, including alcohol. Pre-clinical
Ameer Elena Rasool, Cormac Peat, Jie Liu, Greg Sutherland, Asheeta A. Prasad   +4 more
doaj   +1 more source

SAT1, a glutamine transporter, is preferentially expressed in GABAergic neurons

Frontiers in Neuroanatomy, 2010
Subsets of GABAergic neurons are able to maintain high frequency discharge patterns, which requires efficient replenishment of the releasable pool of GABA.
Tom Tallak Solbu, Tom Tallak Solbu, Mona Bjørkmo, Mona Bjørkmo, Paul Berghuis, Tibor Harkany, Tibor Harkany, Farrukh A Chaudhry, Farrukh A Chaudhry   +8 more
doaj   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source

Mapping alterations in the local synchrony of the cerebral cortex in schizophrenia

European Psychiatry, 2023
Background Observations from different fields of research coincide in indicating that a defective gamma-aminobutyric acid (GABA) interneuron system may be among the primary factors accounting for the varied clinical expression of schizophrenia.
Jesus Pujol, Nuria Pujol, Anna Mané, Gerard Martínez-Vilavella, Joan Deus, Víctor Pérez-Sola, Laura Blanco-Hinojo   +6 more
doaj   +1 more source

Neonatal Sevoflurane Exposure Induces Long‐Term Cognitive Impairment via Epigenetically Mediated MMP9 Activation and Perineuronal Net Disruption in the Hippocampal CA2

Advanced Science, EarlyView.
Hippocampal CA2 perineuronal nets ensheathing excitatory pyramidal neurons are selectively vulnerable to repeated neonatal sevoflurane exposure. Epigenetic upregulation of MMP9 via reduced H3K27me3 disrupts PNN integrity, impairs BDNF–TrkB signaling, and causes synaptic protein loss and dendritic spine deficits, leading to persistent social and spatial
Lirong Liang, Jiachen Wang, Taozhi Wang, Yanling Li, Youyi Zhao, Guanghui Hao, Peiqin Gong, Ruling Chen, Yilin Fang, Shengxi Wu, Haopeng Zhang, Hui Zhang   +11 more
wiley   +1 more source