Results 71 to 80 of about 51,758 (256)

Co-localization between GAD67 and parvalbumin in two different colors.

, 2012
The color of both anti-GAD67 and anti-parvalbumin images was inverted. The bright signal in the inverted GAD67 and parvalbumin images was further replaced with green and red colors respectively (a).
Virawudh Soontornniyomkij (182426), Baohu Ji (182429), MinJung Kim (5649019), Xianjin Zhou (182433)   +3 more
core   +1 more source

New insights into epileptic spasm generation and treatment from the TTX animal model

Epilepsia Open, EarlyView.
Abstract Currently, we have an incomplete understanding of the mechanisms underlying infantile epileptic spasms syndrome (IESS). However, over the past decade, significant efforts have been made to develop IESS animal models to provide much‐needed mechanistic information for therapy development.
John W. Swann, Carlos J. Ballester‐Rosado, Chih‐Hong Lee   +2 more
wiley   +1 more source

Digestibility and IgE-Binding of Glycosylated Codfish Parvalbumin

, 2013
Food-processing conditions may alter the allergenicity of food proteins by different means. In this study, the effect of the glycosylation as a result of thermal treatment on the digestibility and IgE-binding of codfish parvalbumin is investigated ...
Timmerman, E., Baumert, Joseph L., Nordlee, J.A., Jongh, H.H.J., de, Hamilton, Robert G., de Jongh, H.H.J., Taylor, Steve L., Lee, Poi-Wah, Koppelman, Stef J., Lee, P.W., Timmerman, Eefjan, Robles, C.L., Hamilton, R.G., Nordlee, Julie A., Koppelman, S.J., de Jongh, Harmen H. J., Taylor, S.L., López Robles, Carlos, Baumert, J.L.   +18 more
core   +1 more source

Absence seizures: Update on signaling mechanisms and networks

Epilepsia Open, EarlyView.
Abstract Absence seizures (AS) are a hallmark of genetic generalized epilepsies (GGE), characterized by brief episodes of impaired consciousness accompanied by electroencephalographic spike‐and‐wave discharges (SWDs). Traditionally attributed to cortico‐thalamo‐cortical (CTC) dysrhythmia, emerging evidence suggests a more intricate pathophysiological ...
Ozlem Akman, Filiz Onat
wiley   +1 more source

Cell-type-specific control of basolateral amygdala neuronal circuits via entorhinal cortex-driven feedforward inhibition

eLife, 2020
The basolateral amygdala (BLA) plays a vital role in associating sensory stimuli with salient valence information. Excitatory principal neurons (PNs) undergo plastic changes to encode this association; however, local BLA inhibitory interneurons (INs ...
E Mae Guthman, Joshua D Garcia, Ming Ma, Philip Chu, Serapio M Baca, Katharine R Smith, Diego Restrepo, Molly M Huntsman   +7 more
doaj   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Increased Dendritic Branching of and Reduced δ-GABAA Receptor Expression on Parvalbumin-Positive Interneurons Increase Inhibitory Currents and Reduce Synaptic Plasticity at Puberty in Female Mouse CA1 Hippocampus

Frontiers in Cellular Neuroscience, 2020
Parvalbumin positive (PV+) interneurons play a pivotal role in cognition and are known to be regulated developmentally and by ovarian hormones. The onset of puberty represents the end of a period of optimal learning when impairments in synaptic ...
Hui Shen, Hui Shen, Lindsay Kenney, Lindsay Kenney, Sheryl S. Smith, Sheryl S. Smith   +5 more
doaj   +1 more source

Modulation of parvalbumin expression in the motor cortex of parkinsonian rats

, 2005
Dopamine deficiency in Parkinson's disease leads to numerous molecular changes in basal ganglia. However, the consequences of these changes on the motor cortex remain unclear.
Burgunder, Jean-Marc, Capper-Loup, Christine, Capper-Loup, C., Burgunder, J.-M., Kaelin-Lang, A., Kaelin-Lang, Alain   +5 more
core   +1 more source

Progressive myoclonus epilepsy in Down syndrome with Alzheimer's disease: An 11‐year longitudinal study and proposed diagnostic red flags

Epilepsia Open, EarlyView.
Abstract Objective Individuals with Down syndrome (DS) face an ultra‐high risk of Alzheimer's disease (AD). Within this continuum, Progressive Myoclonus Epilepsy (PME) has emerged as a marker of advanced neurodegeneration. Building on our 2014 characterization of this syndrome, we aimed to define its long‐term natural history and pathological substrate.
Giuseppe d'Orsi, Ezio Calò, Maria Teresa Di Claudio, Carmela Pia Ferro, Umberto Costantino, Elio Perrone, Raffaela Rita Latino   +6 more
wiley   +1 more source