Results 131 to 140 of about 5,280 (145)

PARP Inhibitors as Therapeutics: Beyond Modulation of PARylation

Cancers, 2020
Poly (ADP-ribose) polymerase (PARP) 1 is an essential molecule in DNA damage response by sensing DNA damage and docking DNA repair proteins on the damaged DNA site through a type of posttranslational modification, poly (ADP-Ribosyl)ation (PARylation ...
Seock-Ah Im
exaly   +2 more sources

PARylation During Transcription: Insights into the Fine-Tuning Mechanism and Regulation [PDF]

Cancers, 2020
Transcription is a multistep, tightly regulated process. During transcription initiation, promoter recognition and pre-initiation complex (PIC) formation take place, in which dynamic recruitment or exchange of transcription activators occur.
Tibor Pankotai, Barbara Nikolett Borsos, Zsuzsanna Újfaludi   +2 more
exaly   +2 more sources

The Enigmatic Function of PARP1: From PARylation Activity to PAR Readers

Cells, 2019
Poly(ADP-ribosyl)ation (PARylation) is catalysed by poly(ADP-ribose) polymerases (PARPs, also known as ARTDs) and then rapidly removed by degrading enzymes.
Zhao-Qi Wang
exaly   +2 more sources

PARylation of the forkhead‐associated domain protein DAWDLE regulates plant immunity

EMBO Reports, 2016
Protein poly(ADP-ribosyl)ation (PARylation) primarily catalyzed by poly(ADP-ribose) polymerases (PARPs) plays a crucial role in controlling various cellular responses. However, PARylation targets and their functions remain largely elusive.
Shisong Ma, Brandon Le, Zunyong Liu
exaly   +2 more sources

PARylation of HMGA1 desensitizes esophageal squamous cell carcinoma to olaparib

Clinical and Translational Medicine
As a chromatin remodelling factor, high mobility group A1 (HMGA1) plays various roles in both physiological and pathological conditions. However, its role in DNA damage response and DNA damage‐based chemotherapy remains largely unexplored. In this study,
Yuan Zhao, Chen‐Guang Wu, Yun‐Fan Wang, Kai‐Yue He, Jing‐Yu Yang, Huai Liu, Lei Zhang, Yong‐Ping Jian, Qian‐Hui Sun, Qiu‐Tong Li, Zi‐Long Zhao, Xin‐Yuan Lei, Yu‐Jia Li, Zhi‐Xiang Xu, Meng‐Jie Liu, Jin‐Rong Guo, Geng‐Sheng Cao, Gang Wang, Dan‐Hui Wu, Jun‐Qi Li   +19 more
exaly   +2 more sources

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Muscle PARP1 inhibition extends lifespan through AMPKα PARylation and activation in Drosophila

Proceedings of the National Academy of Sciences of the United States of America, 2023
Qiongyue Zhang, Shuang Zhang, Yonghao Feng   +2 more
exaly  

A new underlying mechanism for the neuroprotective effect of bosutinib: Reverting toxicity‐induced PARylation in SIN1‐mediated neurotoxicity

Journal of Biochemical and Molecular Toxicology, 2021
Sinem Yilmaz, Petek Ballar Kirmizibayrak   +1 more
exaly  

PARP-mediated PARylation of MGMT is critical to promote repair of temozolomide-induced O6-methylguanine DNA damage in glioblastoma

Neuro-Oncology, 2021
John de Groot, W K Alfred Yung, Xiaolong Li   +2 more
exaly  

p53 Loss Mediates Hypersensitivity to ETS Transcription Factor Inhibition Based on PARylation-Mediated Cell Death Induction

Cancers, 2020
Christine Pirker, Gerald Timelthaler, Sabine Spiegl-Kreinecker   +2 more
exaly  

Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality

Cancer Cell, 2018
Marieke van de Ven, Haico van Attikum, Marcel van Vugt   +2 more
exaly