Results 111 to 120 of about 6,824 (230)
The role of ADP-ribosylation in regulating DNA interstrand crosslink repair [PDF]
, 2016 ADP-ribosylation by ADP-ribosyltransferases (ARTs) has a wellestablished role in DNA strand break repair by promoting enrichment of repair factors at damage sites through ADP-ribose interaction domains. Here, we exploit the simple eukaryote Dictyostelium
Ahel, Ivan +10 more
core +4 more sources
PARP-1 and PARylation inhibit TET1 demethylation activity [PDF]
, 2020 Since our previous work indicated interplay of Ten-eleven translocation (TET) and Poly (ADP-ribose) polymerase (PARP) proteins our aim was to further study the effects of their interaction. The ability of recombinant PARP-1 to poly ADP-ribosylate (PARylate) catalytic domains of TET proteins was examined in vitro.
Tolić, Anja +11 more
openaire
Life Science AllianceOur current work demonstrates that the non-covalent PARylation of HuR plays a key role in regulating its pro-apoptotic function by preventing its cytoplasmic localization and cleavage.
Kholoud Ashour +11 more
doaj +1 more source
Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney [PDF]
, 2014 Inflammation is accompanied by the release of highly reactive oxygen and nitrogen species (RONS) that damage DNA, among other cellular molecules. Base excision repair (BER) is initiated by DNA glycosylases and is crucial in repairing RONS-induced DNA ...
Abolhassani, Nona +9 more
core +1 more source
TSG101 Associates with PARP1 and is Essential for PARylation and DNA Damage-induced NF-κB Activation [PDF]
, 2021 Ahmet Buğra Tufan +5 more
openalex +1 more source
Redox BiologyBackground: Type 2 diabetes mellitus (T2DM) is characterized by disrupted glucose homeostasis and metabolic abnormalities, with oxidative stress and inflammation playing pivotal roles in its pathophysiology.
Michele Zampieri +12 more
doaj +1 more source
Poly-ADP Ribosyl Polymerase 1 (PARP1) Regulates Influenza A Virus Polymerase
Advances in Virology, 2019 Influenza A viruses (IAV) are evolutionarily successful pathogens, capable of infecting a number of avian and mammalian species and responsible for pandemic and seasonal epidemic disease in humans.
Liset Westera +5 more
doaj +1 more source
NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair
Cell Reports, 2019 Summary: Although poly-ADP-ribosylation (PARylation) of DNA repair factors had been well documented, its role in the repair of DNA double-strand breaks (DSBs) is poorly understood.
Deeksha Munnur +9 more
doaj +1 more source
SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites [PDF]
, 2015 Román González‐Prieto +4 more
openalex +1 more source
Impaired PARylation Turnover in Radiation- Damaged Tissue
PARP inhibitors are used in tumor therapy exploiting their inhibitory role in DNA repair. Radiation therapy leads to DNA damage in the affected region comprising both tumor tissue and adjacent normal tissue. In addition, radiotherapy has long-standing effects on DNA integrity. The mechanisms for this are not well understood.
Felicitas Mayer +5 more
openaire +1 more source