Results 121 to 130 of about 6,824 (230)

PARP1-driven repair of topoisomerase IIIα DNA-protein crosslinks by FEN1

Cell Reports
Summary: Persistent DNA-protein crosslinks formed by human topoisomerase IIIα (TOP3A-DPCs) interfere with DNA metabolism and lead to genome damage and cell death.
Liton Kumar Saha, Yilun Sun, Sourav Saha, Xi Yang, Yves Pommier   +4 more
doaj   +1 more source

Functional Implications of DNA Methylation in Adipose Biology. [PDF]

, 2019
The twin epidemics of obesity and type 2 diabetes (T2D) are a serious health, social, and economic issue. The dysregulation of adipose tissue biology is central to the development of these two metabolic disorders, as adipose tissue plays a pivotal role ...
Kang, Sona, Ma, Xiang
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Poly(ADP-ribose)-binding protein RCD1 is a plant PARylation reader regulated by Photoregulatory Protein Kinases [PDF]

, 2023
Julia P. Vainonen, Richard Gossens, Julia Krasensky-Wrzaczek, Raffaella De Masi, Iulia Danciu, Tuomas Puukko, Natalia Battchikova, Claudia Jonak, Lennart Wirthmueller, Michael Wrzaczek, Alexey Shapiguzov, Jaakko Kangasjärvi   +11 more
openalex   +1 more source

YY1 drives PARP1 expression essential for PARylation of NONO in mRNA maturation during neuroblastoma progression

Journal of Translational Medicine
Background Neuroblastoma (NB), the most prevalent solid tumor in children, arises from sympathetic nervous system and accounts for 15% of pediatric cancer mortality.
Chunhui Yang, Jiaying Qu, Yang Cheng, Minxiu Tian, Zhijie Wang, Xiaolin Wang, Xinyue Li, Shunchen Zhou, Bosen Zhao, Yanhua Guo, Liduan Zheng, Qiangsong Tong   +11 more
doaj   +1 more source

Új mechanizmusok azonosítása az oxidatív stressz indukálta mitokondrium-függő nekrotikus sejthalálban = Identification of novel mechanisms in the oxidative stress induced mitochondria-related necrotic cell death [PDF]

, 2013
Oxidatív stress körülményei között kimutattuk, hogy a PARP enzim gátlása növeli az MKP-1 expresszióját (ez a foszfatáz felelős elsődlegesen a JNK és p38 MAPK inaktivációjáért), ezért szerepet játszhat a PARP gátlás mediálta mitokondriális védelem ...
Bognár, Zita, Gallyas, Ferenc, Kovács, Krisztina, Ohmacht, Róbert, Radnai, Balázs, Rácz, Boglárka, Sümegi, Balázs, Tucsek, Zsuzsanna, Veres, Balázs   +8 more
core  

PARP1 changes from three-dimensional DNA damage searching to one-dimensional diffusion after auto-PARylation or in the presence of APE1 [PDF]

, 2017
Lili Liu, Muwen Kong, Natalie R. Gassman, Bret Freudenthal, Rajendra Prasad, Stephanie Zhen, Simon C. Watkins, Samuel H. Wilson, Bennett Van Houten   +8 more
openalex   +1 more source

Nudix Hydrolase 13 Impairs the Initiation of Colorectal Cancer by Inhibiting PKM1 ADP‐Ribosylation

Advanced Science
Metabolic dysregulation has been implicated as a key factor in colorectal cancer (CRC) initiation, however, the underlying driving forces and mechanisms remain poorly understood.
Jinlong Lin, Yixin Yin, Jinghua Cao, Bingxu Zou, Kai Han, Yufan Chen, Siyu Li, Cijun Huang, Jiewei Chen, Yongrui Lv, Shuidan Xu, Dan Xie, Fengwei Wang   +12 more
doaj   +1 more source

PARG inhibition in ATM-deficient prostate cancer: from mechanistic discovery to therapeutic potential

Journal of Translational Medicine
Background ATM deficiency is frequently observed in castration-resistant prostate cancer (CRPC). However, effective therapeutic vulnerabilities associated with this genetic alteration remain poorly defined.
Xuan Zhou, Chunyu Guo, Zhiguo Fan, Yihaoyun Lou, Zhiying Yue, Weidong Xu, Zhixiang Xin, Shancheng Ren   +7 more
doaj   +1 more source

Increased PARylation impacts the DNA methylation process in type 2 diabetes mellitus [PDF]

, 2021
Michele Zampieri, Maria Giulia Bacalini, Ilaria Barchetta, Stefania Scalea, Flavia Agata Cimini, Laura Bertoccini, Stefano Tagliatesta, Giovanna De Matteis, Giuseppe Zardo, Maria Gisella Cavallo, Anna Reale   +10 more
openalex   +1 more source

A sejtmag és a mitokondriumok közötti kommunikáció poli-ADP-ribozilációs szabályozása oxidatív stresszben = Regulation of nuclear-mitochondrial crosstalk by poly-ADP-ribosylation in oxidative stress [PDF]

, 2010
Kutatásainkban egy poli-ADP-ribozilációnak (PARiláció) nevezett fehérjemódusítást tanulmányoztunk és vizsgáltuk, milyen szerepet játszik a sejthalál és a gyulladás folyamatainak szabályozásában. Olyan sejtvonalakat állítottunk elő, melyekben inaktiváltuk
Bakondi, Edina, Virág, László
core