Results 121 to 130 of about 5,280 (145)

Nicotinamide Mononucleotide Adenylyltransferase 1 and NAD⁺ Homeostasis in Neuroprotection and Aging. [PDF]

Metabolites
Sun Y, Li B, Qian Z.
europepmc   +1 more source

SLFN11 expression as a marker of small cell lung cancer vulnerability to combined PARP inhibitors and immune checkpoint inhibitors during maintenance. [PDF]

J Thorac Dis
Pujol JL.
europepmc   +1 more source

Chromatin relaxation dynamics and histone PTMs in the early DNA damage response. [PDF]

Cancer Biol Med
Qian J, Xie Z, Zhou L, Zhu WG.
europepmc   +1 more source

DNA-PKcs and PARP1 at the interface between DNA damage responses and cGAS-STING signaling: context-dependent roles and therapeutic implications. [PDF]

Cancer Biol Ther
Miao T, Zhao J, Wu J, Hou J, Ma T, Wang G.   +5 more
europepmc   +1 more source

Molecular Determinants of Response and Rational Drug Combinations for Antibody-Drug Conjugates (ADCs) with Topoisomerase I (TOP1) Inhibitor Payloads. [PDF]

J Mol Biol
Pommier Y.
europepmc   +1 more source

Disrupting the tumor-associated TNKS-USP25 protein-protein interface in cancer: structural basis, druggability, and therapeutic opportunities. [PDF]

RSC Adv
Kamel EM, Khadrawy SM, Ali MAM, Ahmed NA, Alkhedhairi S, Aba Alkhayl FF, Lamsabhi AM.   +6 more
europepmc   +1 more source

Poly(ADP-ribose) polymerase (PARP) inhibitors in cardiovascular, and cerebrovascular diseases: mechanisms, current trends and challenge for clinical translation. [PDF]

PeerJ
Fan J, Song Y.
europepmc   +1 more source

Mapping the Subtype-Specific PARP1 ADP-Ribosylated Proteome in Breast Cancer Cells. [PDF]

Mol Cancer Res
Koul S, Kwon M, Tapadar P, Dai Y, Song W, Dasovich M, Nandu T, Huang D, Camacho CV, Kraus WL.   +9 more
europepmc   +1 more source

Shuttle and stabilize: H1.2-FUS complex in amyotrophic lateral sclerosis pathogenesis. [PDF]

Neural Regen Res
Petrovic D, Perçin G, Vilchez D.
europepmc   +1 more source

A Double-Edged Sword: The Two Faces of PARylation

International Journal of Molecular Sciences, 2022
Poly ADP-ribosylation (PARylation) is a post-translational modification process. Following the discovery of PARP-1, numerous studies have demonstrated the role of PARylation in the DNA damage and repair responses for cellular stress and DNA damage ...
Jun Hong Park, Hee Gu Lee, Seong-Hoon Park   +2 more
exaly   +2 more sources