Results 51 to 60 of about 126 (118)

Smiles/Pudovik/Phospha–Brook Cascades from Passerini–Smiles Adducts

ChemistryEurope, Volume 4, Issue 6, June 2026.
The Passerini–Smiles reaction of aliphatic ketophosphonates affords starting materials for complex cascades triggered by a first Smiles rearrangement. The cascade showcases the power of phosphorous based transformations. Here the reversibility of the Pudovik reaction allows a further Truce–Smiles reaction enol before final Pudovik/Phosph–Brook sequence.
Cristina Cheibas, Nicolas Casaretto, Laurent El Kaim   +2 more
wiley   +1 more source

Exploring the Environmental Sustainability of Primary Al–Air Batteries for Long‐Term Energy Storage Applications

ChemSusChem, Volume 19, Issue 8, 28 April 2026.
An exploratory life cycle assessment compares aluminum–air batteries with gaseous and liquefied hydrogen for long‐term energy storage. The results reveal strong trade‐offs between climate benefits, resource burdens, and system efficiency, highlighting key hot spots and showing how decarbonized smelting and circular material flows can improve the ...
Hüseyin Ersoy, Manuel J. Baumann, Friedrich B. Jasper, Christina Wulf, Marcel Weil, Tomás B. Ramos, Stefano Passerini   +6 more
wiley   +1 more source

Arbor Accidents and Asteroids

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Nocardia infection should be considered in immunocompromised patients presenting with concurrent pulmonary and neurological symptoms. Species identification and antimicrobial susceptibility testing are crucial. Co‐trimoxazole is the first‐line treatment.
Varun Mamidi, Constantina Chrysochou
wiley   +1 more source

Accessing Promising Passerini Adducts in Anticancer Drug Design

Molecules
The 3-component Passerini reaction (3CPR), discovered little more than 100 years ago, has been demonstrated in the last few decades to be a valuable tool for accessing structural diversity and complexity, essential topics to consider in drug discovery ...
Ana Margarida Janeiro, Aday González-Bakker, José M. Padrón, Carolina S. Marques   +3 more
doaj   +1 more source

Synthesis of (macro)heterocycles by consecutive/repetitive isocyanide-based multicomponent reactions

Beilstein Journal of Organic Chemistry, 2019
Isocyanide-based multicomponent reactions are a versatile tool in the synthesis of heterocycles. This review describes recently developed approaches based on the combination of consecutive or repetitive isocyanide-based multicomponent reactions for the ...
Angélica de Fátima S. Barreto, Carlos Kleber Z. Andrade   +1 more
doaj   +1 more source

Exploring Phthalimide as the Acid Component in the Passerini Reaction

Organic Letters
Multicomponent reactions, particularly the Passerini reaction, serve as efficient tools for the synthesis of druglike molecules and the creation of compound libraries. Despite the effectiveness of the Passerini reaction, the limited alternatives to the crucial carboxylic acid component pose a structural constraint.
Jingyao Li, Qiang Zheng, Alexander Dömling   +2 more
openaire   +2 more sources

Innovative synthesis of drug-like molecules using tetrazole as core building blocks

Beilstein Journal of Organic Chemistry
Tetrazole is widely utilized as a bioisostere for carboxylic acid in the field of medicinal chemistry and drug development, enhancing the drug-like characteristics of various molecules.
Jingyao Li, Ajay L. Chandgude, Qiang Zheng, Alexander Dömling   +3 more
doaj   +1 more source

Derivatization of Abietane Acids by Peptide-like Substituents Leads to Submicromolar Cytotoxicity at NCI-60 Panel

Molecules
Natural compounds, including diterpenoids, play a critical role in various biological processes and are recognized as valuable components in cancer treatment.
Elena Tretyakova, Anna Smirnova, Denis Babkov, Oxana Kazakova   +3 more
doaj   +1 more source

Total Synthesis of 4-epi-Bengamide E

Molecules
Bengamide E is a bioactive natural product that was isolated from Jaspidae sponges by Crews and co-workers in 1989. It displays a wide range of biological activities, including antitumor, antibiotic, and anthelmintic properties.
Gabriella Vitali Forconesi, Andrea Basso, Luca Banfi, Davide Gugliotta, Chiara Lambruschini, Marta Nola, Renata Riva, Valeria Rocca, Lisa Moni   +8 more
doaj   +1 more source

Synthesis of Novel Indole Derivatives, Antiproliferative Activity, Apoptosis, and Molecular Docking Studies

Acta Chimica Slovenica
Novel indole-containing analogs were synthesized via a one-pot, multi-component Passerini reaction and subsequently evaluated for their anticancer activity against HeLa, MCF-7, and A549 cancer cell lines using the MTT assay.
Mahsa Toolabi, Zahra Sabzevari, Zakaria Forouzanfar, Ayyub Mojaddami   +3 more
doaj   +1 more source