Results 21 to 30 of about 326,331 (291)
Data in Brief, 2021 Multiple processes shape calcium signals in neurons. The spatial and temporal dynamics of these signals are determined by various cellular parameters, including the calcium influx, calcium buffering, and calcium extrusion.
Simon Hess +2 more
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Deep learning-based real-time detection of neurons in brain slices for in vitro physiology
Scientific Reports, 2021 A common electrophysiology technique used in neuroscience is patch clamp: a method in which a glass pipette electrode facilitates single cell electrical recordings from neurons.
Mighten C. Yip +4 more
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Patch-clamp and multi-electrode array electrophysiological analysis in acute mouse brain slices
STAR Protocols, 2021 Summary: Patch-clamp and multi-electrode array electrophysiology techniques are used to measure dynamic functional properties of neurons. Whole-cell and cell-attached patch-clamp recordings in brain slices can be performed in voltage-clamp and current ...
Kevin M. Manz +3 more
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Correction of conductance measurements in non-space-clamped structures: 1. Voltage-gated K+ channels [PDF]
, 2003 To understand functions of a single neuron, such as propagation and generation of synaptic or action potentials, a detailed description of the kinetics and distribution of the underlying ionic conductances is essential.
Korngreen, A +12 more
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Stem Cell Research, 2019 Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have evolved into widely used and reliable cell sources for modeling cardiovascular channelopathies and for drug safety pharmacology.
Wener Li +6 more
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Early identification of hERG liability in drug discovery programs by automated patch clamp
Frontiers in Pharmacology, 2014 Blockade of the cardiac ion channel coded by hERG can lead to cardiac arrhythmia, which has become a major concern in drug discovery and development.
Timm eDanker, Clemens eMöller
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, 2013 Sperm intracellular pH and calcium concentration ([Ca(2+)]i) are two central factors that control sperm activity within the female reproductive tract. As such, the ion channels of the sperm plasma membrane that alter intracellular sperm [Ca(2+)] and pH play important roles in sperm physiology and the process of fertilization. Indeed, sperm ion channels
Polina, Lishko +3 more
openaire +2 more sources
Patch-clamp measurement of ICRAC and ORAI channel activity. [PDF]
, 2014 Depletion of internal Ca(2+) stores activates store-operated Ca(2+) channels. The most prominent members of this class of channels are Ca(2+) release-activated Ca(2+) (CRAC) channels, which are present in a variety of cell types including immune cells ...
Holzmann, Christian +5 more
core +1 more source
Functional dissection of synaptic circuits: in vivo patch-clamp recording in neuroscience
Frontiers in Neural Circuits, 2015 Neuronal activity is dominated by synaptic inputs from excitatory or inhibitory neural circuits. With the development of in vivo patch-clamp recording, especially in vivo voltage-clamp recording, researchers can not only directly measure neuronal ...
Can eTao +3 more
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Wellcome Open Research, 2021 Automated patch-clamp platforms are widely used and vital tools in both academia and industry to enable high-throughput studies such as drug screening. A leak current to ground occurs whenever the seal between a pipette and cell (or internal solution and
Chon Lok Lei +7 more
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