Results 31 to 40 of about 152,269 (192)
Scientific Reports, 2021 The patch-clamp technique and more recently the high throughput patch-clamp technique have contributed to major advances in the characterization of ion channels.
Jérôme Montnach +9 more
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Preparation of Giant Escherichia coli spheroplasts for Electrophysiological Recordings
Bio-Protocol, 2021 Prokaryotic ion channels have been instrumental in furthering our understanding of many fundamental aspects of ion channels’ structure and function. However, characterizing the biophysical properties of a prokaryotic ion channel in a native membrane ...
Yihao Jiang, Vinay Idikuda, Baron Chanda
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Errors in the measurement of voltage-activated ion channels in cell-attached patch-clamp recordings [PDF]
, 2011 Patch-clamp recording techniques have revolutionized understanding of the function and sub-cellular location of ion channels in excitable cells. The cell-attached patch-clamp configuration represents the method of choice to describe the endogenous ...
Williams, Stephen R., Wozny, Christian
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Whole-cell and Perforated Patch-clamp Recordings from Acutely-isolated Murine Sino-atrial Node Cells
Bio-Protocol, 2020 Cardiac pacemaker cells of the sino-atrial node are responsible for the initiation of the heart beat and express an array of ion channels. The patch-clamp technique is the gold standard method for investigating the function of ion channels expressed in ...
Qadeer Aziz +2 more
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Frontiers in Physiology, 2018 An important aspect of the Comprehensive In Vitro Proarrhythmia Assay (CiPA) proposal is the use of human stem cell-derived cardiomyocytes and the confirmation of their predictive power in drug safety assays.
Birgit Goversen +7 more
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Exploring the Coordination of Cardiac Ion Channels With Action Potential Clamp Technique
Frontiers in Physiology, 2022 The patch clamp technique underwent continual advancement and developed numerous variants in cardiac electrophysiology since its introduction in the late 1970s. In the beginning, the capability of the technique was limited to recording one single current
Balázs Horváth +9 more
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Scorpion Venom peptide, AGAP inhibits TRPV1 and potentiates the analgesic effect of lidocaine
Heliyon, 2021 The current study was designed to test the hypothesis that BmK AGAP (AGAP) potentiates the analgesic effect of lidocaine. The chronic constrictive injury was performed on 72 rats to induce a rapid onset and long-lasting pain.
Sylvanus Kampo +6 more
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The development of high quality seals for silicon patch-clamp chips. [PDF]
, 2010 International audiencePlanar patch-clamp is a two-dimensional variation of traditional patch-clamp. By contrast to classical glass micropipette, the seal quality of silicon patch-clamp chips (i.e. seal resistance and seal success rate) have remained poor
Arnoult, Christophe +11 more
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Lack of direct evidence for a functional role of voltage-operated calcium channels in juxtaglomerular cells [PDF]
, 1990 In this study we have examined the role of voltage-gated calcium channels in the regulation of calcium in juxtaglomerular cells. Using a combination of patch-clamp and single-cell calcium measurement we obtained evidence neither for voltage-operated ...
Chegini, S. +3 more
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Frontiers in Aging Neuroscience, 2021 A patch-clamp recording in slices generated from the brain or the spinal cord has facilitated the exploration of neuronal circuits and the molecular mechanisms underlying neurological disorders.
Yang Li +5 more
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