Results 111 to 120 of about 6,734 (227)

Increased risk of pneumonia in residents living near poultry farms: does the upper respiratory tract microbiota play a role? [PDF]

, 2017
BACKGROUND: Air pollution has been shown to increase the susceptibility to community-acquired pneumonia (CAP). Previously, we observed an increased incidence of CAP in adults living within 1 km from poultry farms, potentially related to particulate ...
A Lee, A Morris, A Schulze, A Torres, B Brunekreef, B Neupane, CE Dijk van, EA MacIntyre, EG Huijskens, EGW Huijskens, ES Charlson, F Borlée, GJ Boender, I Hanski, I Letunic, J Almirall, J Grigg, J Lelieveld, J Rylance, J Seedorf, JT Zelikoff, LA Smit, LA Smit, LAM Smit, M Cambra-Lopez, M Jonges, MB Schenker, ME Bos, N Mushtaq, RP Dickson, RP Dickson, S Jain, SB Gordon, T Lindstrom, T Sandstrom, V Poroyko, WA Steenhuijsen Piters de, Y Benjamini   +37 more
core   +3 more sources

Phage Therapy: Targeting the Gut Microbiota for the Treatment of Acute Pancreatitis

Journal of Gastroenterology and Hepatology, EarlyView.
ABSTRACT Acute pancreatitis (AP) is a common clinical inflammatory condition whose severity is closely associated with both local pancreatic injury and systemic complications. Research indicates that gut microbiota dysbiosis and subsequent bacterial translocation can exacerbate disease progression via the gut–pancreas axis, representing a critical ...
Jiawei Chen, Caihan Duan, Keyi Zhang, Jun Liu, Chaoqun Han   +4 more
wiley   +1 more source

Dysfunction of the Intestinal Microbiome in Inflammatory Bowel Disease and Treatment [PDF]

, 2012
Background: The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis result from alterations in intestinal microbes and the immune system.
Bousvaros, Athos, Devaney, Kathryn L, Gevers, Dirk, Huttenhower, Curtis, Korzenik, Joshua, LeLeiko, Neal, Morgan, Xochitl C, Reyes, Joshua Anthony, Sands, Bruce E, Shah, Samir A, Snapper, Scott Brian, Sokol, Harry, Tickle, Timothy L., Ward, Doyle V, Xavier, Ramnik   +14 more
core   +3 more sources

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Interactions between Bacteria and Bile Salts in the Gastrointestinal and Hepatobiliary Tracts [PDF]

, 2017
Bile salts and bacteria have intricate relationships. The composition of the intestinal pool of bile salts is shaped by bacterial metabolism. In turn, bile salts play a role in intestinal homeostasis by controlling the size and the composition of the ...
Casadesús Pursals, Josep, Urdaneta Páez, Verónica Carolina   +1 more
core   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

The Keystone‐Pathogen Hypothesis Updated: The Role of Porphyromonas gingivalis in Periodontitis

Journal of Periodontal Research, EarlyView.
Porphyromonas gingivalis orchestrates a coordinated manipulation of immune and inflammatory responses in periodontal tissues which leads to the generation of a dysbiotic, subgingival biofilm community, and progression of periodontitis. The type 9 secretion system, lipid A modification, and the formation of outer membrane vesicles are important ...
Mike A. Curtis, James A. Garnett, Richard P. Darveau   +2 more
wiley   +1 more source

Gut biogeography of the bacterial microbiota [PDF]

, 2016
Animals assemble and maintain a diverse but host-specific gut microbial community. In addition to characteristic microbial compositions along the longitudinal axis of the intestines, discrete bacterial communities form in microhabitats, such as the gut ...
Donaldson, Gregory P., Lee, S. Melanie, Mazmanian, Sarkis K.   +2 more
core   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

β7 Integrin Inhibition Can Increase Intestinal Inflammation by Impairing Homing of CD25hiFoxP3+ Regulatory T Cells. [PDF]

, 2020
Background & aimsIntegrin α4β7 mediates lymphocyte trafficking to the gut and gut-associated lymphoid tissues, a process critical for recruitment of effector lymphocytes from the circulation to the gut mucosa in inflammatory bowel disease (IBD) and ...
Eckmann, Lars, Ginsberg, Mark H, Kuk, Wun, Lopez-Ramirez, Miguel Alejandro, Rivera-Nieves, Jesús, Sun, Hao   +5 more
core   +1 more source