Results 111 to 120 of about 218,478 (251)

Synergy in Rice Immunity: Exploring Strategies of Coordinated Disease Defense Through Receptor-Like Kinases and Receptor- Like Cytoplasmic Kinases

Rice Science
Receptor-like kinases (RLKs) and receptor-like cytoplasmic kinases (RLCKs) play an indispensable role in the perception and transmission of extracellular signals in plants. In rice, these kinases actively participate in immune responses against a variety
Mengtian Pei, Yingying Cao, Xuze Xie, Ying Cao, Jia Chen, Xi Zhang, Zonghua Wang, Guodong Lu, Shenghang Zhang   +8 more
doaj   +1 more source

Damage-associated molecular patterns and pathogen-associated molecular patterns in severe bacterial infections

<p dir="ltr">Community-acquired bacterial infections can range from mild to severe, including sepsis. The mechanisms driving severe disease and poor outcomes remain unclear. The early host response in sepsis is triggered by pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), which activate the innate ...
openaire   +3 more sources

[Role of cytokines and pathogen associated molecular pattern receptors in sepsis].

Przeglad epidemiologiczny, 2006
Sepsis is life-treating state caused by overwhelming inflammatory response to infection accompanied by disregulation of non-specific immunity mechanisms. In this review we discussed influence of Gram-positive and Gram-negative bacterial virulence factors, cytokines as well as pathogen associated molecular pattern receptors (TLR-toll like receptors ...
Piotr, Kłuciński, Gayane, Martirosian
openaire   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Revealing the Molecular Network of Pattern-Triggered Immunity (PTI) Signal Transduction

Frontiers in Bioscience-Landmark
Pattern-triggered immunity (PTI), the first line of defense in plants, is activated when host pattern recognition receptors (PRRs) detect pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) released during ...
Fengchang Ye, Jiatong Dong, Baishan Liu, Zichuan Zhou, Minzhe Zhang, Chao Han   +5 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Correction: Pathogen-associated molecular pattern-triggered immunity and resistance to the root pathogen Phytophthora parasitica in Arabidopsis. [PDF]

J Exp Bot, 2023
europepmc   +1 more source