Results 81 to 90 of about 387,002 (288)

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Tyrosine-610 in the Receptor Kinase BAK1 Does Not Play a Major Role in Brassinosteroid Signaling or Innate Immunity

Frontiers in Plant Science, 2017
The plasma membrane-localized BRI1-ASSOCIATED KINASE1 (BAK1) functions as a co-receptor with several receptor kinases including the brassinosteroid (BR) receptor BRASSINOSTEROID-INSENSITIVE 1 (BRI1), which is involved in growth, and the receptors for ...
Vijayata Singh, Artemis Perraki, Sang Y. Kim, Sang Y. Kim, Stuti Shrivastava, Jae H. Lee, Youfu Zhao, Benjamin Schwessinger, Man-Ho Oh, Amy Marshall-Colon, Cyril Zipfel, Steven C. Huber, Steven C. Huber   +12 more
doaj   +1 more source

Infectious diseases and autoimmunity [PDF]

, 2011
Introduction: Autoimmunity occurs when the immune system recognizes and attacks host tissue. In addition to genetic factors, environmental triggers (in particular viruses, bacteria and other infectious pathogens) are thought to play a major role in the ...
Deidda, Silvia, Delitala, Giuseppe, Delogu, Lucia Gemma, Manetti, Roberto   +3 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The Lamin-Like LITTLE NUCLEI 1 (LINC1) Regulates Pattern-Triggered Immunity and Jasmonic Acid Signaling

Frontiers in Plant Science, 2020
Pathogen-associated molecular pattern (PAMP) recognition occurs by plasma membrane located receptors that induce among other processes nuclear gene expression.
Mai Jarad, Kiruthiga Mariappan, Marilia Almeida-Trapp, Michael Florian Mette, Axel Mithöfer, Naganand Rayapuram, Heribert Hirt   +6 more
doaj   +1 more source

Hierarchy and Roles of Pathogen-Associated Molecular Pattern-Induced Responses in Nicotiana benthamiana     [PDF]

Plant Physiology, 2011
Abstract Our current understanding of pathogen-associated molecular pattern (PAMP)-triggered immunity signaling pathways in plants is limited due to the redundancy of several components or the lethality of mutants in Arabidopsis (Arabidopsis thaliana). To overcome this, we used a virus-induced gene silencing-based approach in combination
Segonzac, Cécile, Feike, Doreen, Gimenez-Ibanez, Selena, Hann, Dagmar R, Zipfel, Cyril, Rathjen, John P   +5 more
openaire   +4 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The role of effectors in nonhost resistance to filamentous plant pathogens [PDF]

, 2014
In nature, most plants are resistant to a wide range of phytopathogens. However, mechanisms contributing to this so-called nonhost resistance (NHR) are poorly understood.
Aghnoum, Antonovics, Arabidopsis Genome Initiative, Baxter, Bolton, Brunner, Chen, de Jonge, de Jonge, de Wit, Dean, Dong, Elmore, Fan, Fradin, Fry, Gilroy, Gladieux, Haas, Hacquard, Jafary, Jeuken, Jones, Jupe, Jupe, Kang, Karasov, Kaschani, King, Kombrink, Lapin, Lee, Levesque, Lozano-Torres, Ma, Maekawa, Meyers, Mondragon-Palomino, Monosi, Morris, Mueller, Niks, Palloix, Pavan, Pedersen, Porter, Qutob, Raffaele, Raffaele, Raffaele, Rice Genome Project, Rouxel, Ruan, Saunders, Schulze-Lefert, Schweizer, Segretin, Shabab, Shan, Shen, Shindo, Spanu, Stam, Stassen, Stassen, Stirnweis, Stukenbrock, Stukenbrock, Stuttmann, Sweigard, Sørensen, Tian, Tosa, Uma, van Schie, Vega-Arreguín, Vogel, Wawra, Win, Wulff, Zellerhoff, Zhang, Zheng, Zipfel   +83 more
core   +5 more sources

ADP-heptose is a pathogen-associated molecular pattern of Shigella flexneri infection [PDF]

, 2018
ABSTRACT During an infection, the detection of pathogens is mediated through interactions between pathogen-associated molecular patterns (PAMPs) and pathogen recognition receptors. β-Heptose 1,7-bisphosphate (βHBP), a metabolite of the lipopolysaccharide (LPS) biosynthesis pathway, was recently identified as a PAMP of
García-Weber, Diego, Dangeard, Anne-Sophie, Cornil, Johan, Thai, Linda, Rytter, Héloise, Mulard, Laurence A., Arrieumerlou, Cécile   +6 more
openaire   +1 more source