Results 51 to 60 of about 44,783 (256)

Methods to Study PAMP-Triggered Immunity Using Tomato and Nicotiana benthamiana

Molecular Plant-Microbe Interactions, 2010
Understanding the molecular basis of plant responses to pathogen-associated molecular patterns (PAMPs) is an active area of research in the field of plant–microbe interactions.
Hanh P. Nguyen, Suma Chakravarthy, André C. Velásquez, Heather L. McLane, Lirong Zeng, Hitoshi Nakayashiki, Duck-Hwan Park, Alan Collmer, Gregory B. Martin   +8 more
doaj   +1 more source

Plant elicitor peptide 1 fortifies root cell walls and triggers a systemic root-to-shoot immune signaling in Arabidopsis

Plant Signaling & Behavior, 2022
Plant immunity is initiated by cell surface-localized receptors upon perception of pathogen-derived microbe or pathogen-associated molecular patterns (MAMPs/PAMPs), damage/danger-associated molecular patterns (DAMPs), and phytocytokines.
Jie Zhang, Yuxi Li, Qixin Bao, Hongbo Wang, Shuguo Hou   +4 more
doaj   +1 more source

The mechanism of NLRP3 inflammasome activation and its pharmacological inhibitors

Frontiers in Immunology, 2023
NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is a cytosolic pattern recognition receptor (PRR) that recognizes multiple pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).
Xiaoyan Zhan, Xiaoyan Zhan, Qiang Li, Qiang Li, Guang Xu, Guang Xu, Xiaohe Xiao, Xiaohe Xiao, Zhaofang Bai, Zhaofang Bai   +9 more
doaj   +1 more source

Transdermal Delivery of an mRNA‐Liposome Vaccine via Dissolving Microneedle to Preserve Vaccine Activity and Enhance Immune Activation

Advanced Science, EarlyView.
An mRNA‐liposome vaccine via dissolving microneedles (ML‐DMN) enables efficient skin‐targeted delivery while preserving mRNA integrity and allowing sustained antigen expression. Unlike intramuscular (IM) injection, ML‐DMN engages skin‐resident immune cells, activates antigen‐presenting cells (APCs), and induces strong T cell and cytokine responses at ...
Jeehye Nam, JiWon Ahn, Jiwoo Shin, Nahong Lee, Youjin Lee, Sung min Cho, Paul Kim, Geonwoo Kang, Sang‐Jun Ha, Hyungil Jung   +9 more
wiley   +1 more source

Distinct Molecular Mechanisms Underlying Potassium Efflux for NLRP3 Inflammasome Activation

Frontiers in Immunology, 2020
The NLRP3 inflammasome is a core component of innate immunity, and dysregulation of NLRP3 inflammasome involves developing autoimmune, metabolic, and neurodegenerative diseases.
Ziwei Xu, Zi-mo Chen, Xiaoyan Wu, Linjie Zhang, Ying Cao, Pingzheng Zhou   +5 more
doaj   +1 more source

Toll-like receptors in cardiac hypertrophy

Frontiers in Cardiovascular Medicine, 2023
Toll-like receptors (TLRs) are a family of pattern recognition receptors (PRRs) that can identify pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs).
Yanan Zhang, Yanan Zhang, Yanan Zhang, Yanan Zhang, Yanan Zhang, Yanan Zhang, Yanan Zhang, Jimin Wu, Jimin Wu, Jimin Wu, Jimin Wu, Jimin Wu, Erdan Dong, Erdan Dong, Erdan Dong, Erdan Dong, Erdan Dong, Zhanli Wang, Zhanli Wang, Han Xiao, Han Xiao, Han Xiao, Han Xiao, Han Xiao   +23 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Engineering Oncolytic Virus‐Armed Macrophages for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
ZIFOA‐M is engineered by conjugating oncolytic adenovirus‐loaded ZIF‐8 nanoparticles onto macrophage surfaces via bioorthogonal chemistry. Upon tumor infiltration, the platform releases OA to downregulate CD47/CD24 on tumor cells, restoring macrophage phagocytosis.
Jilong Wang, Ning Lu, Zhuo Yan, Luyi Ye, Luyao Bai, Shanshan Yuan, Yuting Zhu, Yiru Xiong, Yongheng Bai, Yaping Chen, Junjie Deng   +10 more
wiley   +1 more source

The roles of odontoblasts in dental pulp innate immunity

Japanese Dental Science Review, 2018
Summary: Odontoblasts located in the outermost layer of dental pulp form a natural barrier between mineralized tissues, dentin, and soft tissues, dental pulp, of the vital tooth, and they first recognize caries-related pathogens and sense external ...
Hiromichi Yumoto, Kouji Hirao, Yuki Hosokawa, Hitomi Kuramoto, Daisuke Takegawa, Tadashi Nakanishi, Takashi Matsuo   +6 more
doaj   +1 more source

Battle Royale: Innate Recognition of Poxviruses and Viral Immune Evasion

Biomedicines, 2021
Host pattern recognition receptors (PRRs) sense pathogen-associated molecular patterns (PAMPs), which are molecular signatures shared by different pathogens.
Huibin Yu, Ryan C. Bruneau, Greg Brennan, Stefan Rothenburg   +3 more
doaj   +1 more source