Results 21 to 30 of about 1,726,520 (358)

Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ

Science, 2020
Tetrameric immune receptors Nucleotide-binding/leucine-rich repeat (NLR) immune receptors detect pathogen effectors and trigger a plant's immune response. Two groups have now defined the structures of two NLRs that carry Toll-like interleukin-1 receptor (
Raoul Martin, Tiancong Qi, Haibo Zhang, Furong Liu, Miles King, C. Toth, E. Nogales, B. Staskawicz   +7 more
semanticscholar   +1 more source

Stenoparib, an Inhibitor of Cellular Poly(ADP-Ribose) Polymerase, Blocks Replication of the SARS-CoV-2 and HCoV-NL63 Human Coronaviruses In Vitro

mBio, 2021
New therapeutics are urgently needed in the fight against COVID-19. Repurposing drugs that are either already approved for human use or are in advanced stages of the approval process can facilitate more rapid advances toward this goal.
Nathan E. Stone, Sierra A. Jaramillo, Ashley N. Jones, Adam J. Vazquez, Madison Martz, Lora M. Versluis, Marlee O. Raniere, Haley E. Nunnally, Katherine E. Zarn, Roxanne Nottingham, Ken R. Ng, Jason W. Sahl, David M. Wagner, Steen Knudsen, Erik W. Settles, Paul Keim, Christopher T. French   +16 more
doaj   +1 more source

Identification of proteins associated with pyrethroid resistance by iTRAQ-based quantitative proteomic analysis in Culex pipiens pallens

Parasites & Vectors, 2015
Background Mosquito control based on chemical insecticides is considered as an important element in the current global strategies for the control of mosquito-borne diseases.
Weijie Wang, Yuan Lv, Fujin Fang, Shanchao Hong, Qin Guo, Shengli Hu, Feifei Zou, Linna Shi, Zhentao Lei, Kai Ma, Dan Zhou, Donghui Zhang, Yan Sun, Lei Ma, Bo Shen, Changliang Zhu   +15 more
doaj   +1 more source

Viral pathogens [PDF]

Haemophilia, 2010
Summary.  Despite continuous improvement in safety and purity of blood products for individuals with haemophilia, transmissible agents continue to affect individuals with haemophilia. This chapter addresses three viral pathogens with significant clinical impact: HIV, hepatitis C and parvovirus B19.
J. A. Jordan, M. V. Ragni, K. E. Sherman
openaire   +3 more sources

Pathogenicity of Enterococci [PDF]

Microbiology Spectrum, 2019
ABSTRACT Enterococci are unusually well adapted for survival and persistence in a variety of adverse environments, including on inanimate surfaces in the hospital environment and at sites of infection. This intrinsic ruggedness undoubtedly played a role in providing opportunities for enterococci to interact with other overtly drug-resistant ...
Michael S. Gilmore, Michael S. Gilmore, Elizabeth Fiore, Elizabeth Fiore, Daria Van Tyne, Daria Van Tyne   +5 more
openaire   +3 more sources

An association of Aquaporin-4 with the immunoregulation of liver pathology in mice infected with Schistosoma japonicum

Parasites & Vectors, 2015
Background Schistosomiasis is a chronic parasitic disease that affects approximately 200 million people. In Schistosomiasis japonica and mansoni, parasite eggs were trapped in host liver and stimulated the CD4+T cell responses to regulate the formation ...
Weiwei Zhang, Jifeng Zhu, Xian Song, Zhipeng Xu, Xue Xue, Xiaojun Chen, Xiaowei Yang, Yong Li, Xiaoxiao Dong, Sha Zhou, Wei Li, Yingying Qian, Feng Liu, Chuan Su   +13 more
doaj   +1 more source

Absence of Batf3 results in reduced liver pathology in mice infected with Schistosoma japonicum

Parasites & Vectors, 2017
Background The involvement of CD8+T cells in schistosomiasis is being increasingly appreciated, but the underlying mechanism is not well defined. Results In this study, we showed that the absence of Batf3 alleviated liver damage in Batf3 −/− mice ...
Lin Chen, Donghui Zhang, Wenyue Zhang, Yuxiao Zhu, Min Hou, Bingya Yang, Zhipeng Xu, Minjun Ji, Guanling Wu   +8 more
doaj   +1 more source

ASGDB: a specialised genomic resource for interpreting Anopheles sinensis insecticide resistance

Parasites & Vectors, 2018
Background Anopheles sinensis is an important malaria vector in Southeast Asia. The widespread emergence of insecticide resistance in this mosquito species poses a serious threat to the efficacy of malaria control measures, particularly in China ...
Dan Zhou, Yang Xu, Cheng Zhang, Meng-Xue Hu, Yun Huang, Yan Sun, Lei Ma, Bo Shen, Chang-Liang Zhu   +8 more
doaj   +1 more source

Praziquantel treatment after Schistosoma japonicum infection maintains hepatic insulin sensitivity and improves glucose metabolism in mice

Parasites & Vectors, 2017
Background Epidemiological studies in China have revealed that Schistosoma japonicum infection is inversely correlated with metabolic syndrome, even after repeated chemotherapy with praziquantel (PZQ). We investigated the effect of chronic S.
Xiaofeng Luo, Yuxiao Zhu, Ran Liu, Jingwei Song, Fan Zhang, Wenyue Zhang, Zhipeng Xu, Min Hou, Bingya Yang, Lin Chen, Minjun Ji   +10 more
doaj   +1 more source

Autophagy vitalizes the pathogenicity of pathogenic fungi [PDF]

Autophagy, 2012
Plant pathogenic fungi utilize a series of complex infection structures, in particular the appressorium, to gain entry to and colonize plant tissue. As a consequence of the accumulation of huge quantities of glycerol in the cell the appressorium generates immense intracellular turgor pressure allowing the penetration peg of the appressorium to ...
Fei Xu, Fu-Cheng Lin, Rodney J. Devenish, Jian-Ping Lu, Hui-Min Gao, Xiao-Hong Liu   +5 more
openaire   +3 more sources