Results 201 to 210 of about 221,631 (251)

Etiology Model of Kawasaki Disease and Multisystem Inflammatory Syndromes: Mast Cell Activation. [PDF]

Curr Issues Mol Biol
Ricke DO.
europepmc   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

How to frustrate a plant pathogen. [PDF]

Plant J
Knight G, Heddle J, Bentham AR.
europepmc   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

PGPR-Mediated Plant Immunity: From Microbial Recognition to Epigenetic Priming. [PDF]

Plants (Basel)
Unal D, Satimova S, Botirova D, Muhammad M, Egamberdieva D.   +4 more
europepmc   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

A multiplant transcriptomic atlas reveals conserved and lineage-specific defense architectures in response to <i>Botrytis cinerea</i>. [PDF]

Proc Natl Acad Sci U S A
Singh R, Muhich AJ, Tom C, Caseys C, Kliebenstein DJ.   +4 more
europepmc   +1 more source

Paleopathology Meets Public Health: Deep-Time Syndemics and the Ecology of Emerging Infections. [PDF]

Pathogens
Bahmad HF, Ghssein G, Bahmad M, Elajami TK, Forghani I, Tuda C, Ruiz-Cordero R.   +6 more
europepmc   +1 more source

Unlocking Grass Stress Resistance: Fungal Endophyte-Mediated Pathogen Recognition and RNA Regulation. [PDF]

Int J Mol Sci
Ahmad A, Ahmed MM, Akhtar A, Liu W, Yang R, Sun X, Wang X, Bibi S, Khan MB, Chen S.   +9 more
europepmc   +1 more source