Results 171 to 180 of about 6,916,201 (263)

Dual Compartmentalization of GSTA4 Suppresses Ferroptosis to Drive Antiandrogen Resistance in Prostate Cancer

Advanced Science, EarlyView.
The schematic diagram depicts a compartmentalized anti‐ferroptotic defense mechanism mediated by GSTA4. GSTA4 is upregulated and localizes to the cytoplasm in ENZR cells, where it detoxifies 4‐HNE via a non‐canonical GSH‐dependent pathway. Under oxidative stress, GSTA4 translocates to mitochondria, interacts with PGAM5, and blocks Drp1 Ser637 ...
Yong Luo, Wei Zhuang, Zean Li, Yiming Lai, Yongyi Ou, Dongquan Li, Shanhe Huang, Tianlong Luo, Jintao Hu, Bingliang Chen, Jianhan Fu, Tao Zhuo, Hankun Jiang, Yin Lu, Hai Huang, Kewei Xu, Shengmeng Peng, Qing Yuan   +17 more
wiley   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

From patient-derived tumor organoids to personalized cancer therapy: advancing treatment for advanced solid tumors. [PDF]

Front Oncol
Wang G, Tan Z, Jia W, Liu Y, Wang H, Sun W, Sun W, Meng L, Zhang Y, Liu N, Li F, Dong H.   +11 more
europepmc   +1 more source

Replication Data for Breast Cancer Patient-derived Organoids as case study for the investigation of patient’s specific tumour evolution

This dataset contains raw data of results published in Mazzucchelli S. et al. "Breast Cancer Patient-derived Organoids as case study for the investigation of patient’s specific tumour evolution". This dataset reports a case-study of breast cancer patient-
Mazzucchelli, Serena
core   +1 more source

Real‐Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids

Advanced Science, EarlyView.
This study introduces photothermally actuated microcantilevers combined with optical microscopy to simultaneously measure morphology, mass, and mechanical properties of cellular systems in real‐time. The findings link cytoplasm‐dominated mechanical energy dissipation to the Q‐factor as a novel biophysical parameter.
Ilaria Incaviglia, Giulia E. M. Ammirati, Sophie Herzog, Tommy Krug, Nico Strohmeyer, Miguel Camacho Rufino, Matthias P. Lutolf, David A. Weitz, Daniel J. Müller   +8 more
wiley   +1 more source

Molecular Landscapes of Tumor Dormancy in Gynecologic Malignancies: From Survival Mechanisms to Precision Interception

Advanced Science, EarlyView.
This Review outlines the biological framework of entry, maintenance, and awakening in dormant minimal residual disease across gynecologic cancers. By mapping critical biological dependencies—from metabolic plasticity to microenvironment interactions—it evaluates novel interception concepts and presents a translational framework combining single‐cell ...
Shih‐Hsuan Cheng, Ren‐Wang Peng, Chang‐Cheng Wu, Chi‐Wen Luo, Emmanuel Naveen Raj, Zhi‐Hong Wen, Tzu‐Hung Hsiao, Chia‐Jung Li   +7 more
wiley   +1 more source

Patient-Derived Tumor Organoids Can Predict the Progression-Free Survival of Patients With Stage IV Colorectal Cancer After Surgery. [PDF]

Dis Colon Rectum, 2023
Wang T, Tang Y, Pan W, Yan B, Hao Y, Zeng Y, Chen Z, Lan J, Zhao S, Deng C, Zheng H, Yan J.   +11 more
europepmc   +1 more source

Patient-derived tumor organoids for personalized cancer immunotherapy: An immunopeptidome-to-validation approach in RCC and BC. [PDF]

Mol Ther Oncol
Antignani G, Feodoroff M, Chiaro J, Feola S, Russo S, Hamdan Hissaoui F, Fusciello M, D'Alessio F, Bottega P, Giannoula Y, Sakalauskaite M, Sandberg J, Kosonen M, Stigzelius V, Luck TJ, Ferrari V, Ciampi D, Haapala M, Branca RM, Partanen J, Koskela S, Rescigno M, Sikanen T, Lehtiö J, Ndika J, Kari OK, Pietiäinen VM, Grönholm M, Cerullo V.   +28 more
europepmc   +1 more source

Patient-Derived Gastric Cancer Assembloid Model Integrating Matched Tumor Organoids and Stromal Cell Subpopulations

Background/Purpose: Conventional three-dimensional in vitro tumor models often fail to fully capture the complexity of the tumor microenvironment, particularly the diverse populations of cancer-associated fibroblasts that contribute to poor prognosis and
Dikla Rogachevsky, Irit Shapira-Netanelov, Igor Koman, Yael Maizels, Olga Furman, Gabriela A. Rozic, Dmitry Rodin, Galia Luboshits   +7 more
core   +1 more source

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source