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Optimizing patient-derived tumor organoids for translational cancer research
Seghers, Sofie, Deben, Christophe
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Patient-derived tumor organoids for prediction of cancer treatment response [PDF]
Seminars in Cancer Biology, 2018 Cancer treatment, in particular radiotherapy and chemotherapy, is often hindered by an inherent resistance of cancer cells. Cancer stem cells in particular have previously been shown to be more resistant than other cells within a tumor and are thought ...
Robert P. Coppes +2 more
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Next generation patient derived tumor organoids
Translational Research, 2022Patient-derived tumor organoids (PDTOs) have emerged as exceptional pre-clinical models as they preserved, in most of the cases, the mutational landscape and tumor-clonal heterogeneity of the primary tumors. Despite being extensively used in disease modelling as well as in precision medicine for drug testing and discovery, they still have some ...
Hui-Hsuan Kuo +2 more
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Patient-derived organoids as a model for tumor research
2022Cancer represents a leading cause of death, despite the rapid progress of cancer research, leading to urgent need for accurate preclinical model to further study of tumor mechanism and accelerate translational applications. Cancer cell lines cannot fully recapitulate tumors of different patients due to the lack of tumor complexity and specification ...
Jia, Wang +4 more
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Patient-Derived Cancer Organoids as Predictors of Treatment Response
Frontiers in Oncology, 2021 Patient-derived cancer organoids have taken a prominent role in pre-clinical and translational research and have been generated for most common solid tumors.
Maikel Verduin, Ann Hoeben, Marc Vooijs
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Comparative Study of Organoids from Patient-Derived Normal and Tumor Colon and Rectal Tissue [PDF]
Cancers, 2020 Colon and rectal tumors, often referred to as colorectal cancer, show different gene expression patterns in studies that analyze whole tissue biopsies containing a mix of tumor and non-tumor cells. To better characterize colon and rectal tumors, we investigated the gene expression profile of organoids generated from endoscopic biopsies of rectal tumors
Antonio Barbáchano +2 more
exaly +7 more sources
Patient‐derived organoid model of olfactory ensheathing cell tumor
International Forum of Allergy & RhinologyKey points We developed a culture model of a human olfactory ensheathing cell tumor. Cultured organoids resemble normal ensheathing cells. Assays suggest that this model provides a tool for studying the roles of these glial cells in the maintenance of the peripheral olfactory system.
John B. Finlay +3 more
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Efficient use of patient-derived organoids as a preclinical model for gynecologic tumors
Gynecologic Oncology, 2019The relevance of patient-derived cancer cells has been recently increasing, particularly in terms of drug discovery and precision medicine. Whereas Matrigel-based organoid culture is a promising technique that enables infinite proliferation of cells from many types of organs in a physiological condition, its validity in gynecologic tumors remains to be
Yoshiaki Maru +3 more
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Live Imaging to Quantify Cellular Radiosensitivity in Patient-Derived Tumor Organoids
Journal of Visualized ExperimentsRadiation therapy (RT) is one of the mainstays of modern clinical cancer management. However, not all cancer types are equally sensitive to irradiation, often (but not always) because of differences in the ability of malignant cells to repair oxidative DNA damage as elicited by ionizing rays.
Maud, Charpentier +4 more
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