Results 181 to 190 of about 633,152 (295)

Clathrin-dependent endocytosis is required for immunity mediated by pattern recognition receptor kinases

Proceedings of the National Academy of Sciences of the United States of America, 2016
Malick Mbengue, G. Bourdais, F. Gervasi, Martina Beck, Ji Zhou, Thomas Spallek, Sebastian Bartels, T. Boller, T. Ueda, Hannah Kuhn, S. Robatzek   +10 more
semanticscholar   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Immunotherapy with nebulized pattern recognition receptor agonists restores severe immune paralysis and improves outcomes in mice with influenza-associated pulmonary aspergillosis. [PDF]

mBio
Pantaleón García J, Wurster S, Albert ND, Bharadwaj U, Bhoda K, Kulkarni VK, Ntita M, Rodríguez Carstens P, Burch-Eapen M, Covarrubias López D, Foncerrada Lizaola J, Larsen KE, Matula LM, Moghaddam SJ, Wang Y, Kontoyiannis DP, Evans SE.   +16 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

MdSVWC1, a new pattern recognition receptor triggers multiple defense mechanisms against invading bacteria in Musca domestica. [PDF]

BMC Biol
Tang T, Sun S, Wang R, Li M, Wang Y, Li F, Wang Y, Liu F.   +7 more
europepmc   +1 more source

Pattern-Recognition Receptor Agonist-Containing Immunopotentiator CVC1302 Boosts High-Affinity Long-Lasting Humoral Immunity. [PDF]

Front Immunol, 2021
Du L, Hou L, Yu X, Cheng H, Chen J, Zheng Q, Hou J.   +6 more
europepmc   +1 more source

Attenuation of pattern recognition receptor signaling is mediated by a MAP kinase kinase kinase

EMBO Reports, 2016
S. Mithoe, C. Ludwig, M. J. Pel, M. Cucinotta, A. Casartelli, Malick Mbengue, J. Skłenar, P. Derbyshire, S. Robatzek, C. Pieterse, R. Aebersold, Frank L. H. Menke   +11 more
semanticscholar   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Phosphorylation of PFKL regulates metabolic reprogramming in macrophages following pattern recognition receptor activation. [PDF]

Nat Commun
Wang M, Flaswinkel H, Joshi A, Napoli M, Masgrau-Alsina S, Kamper JM, Henne A, Heinz A, Berouti M, Schmacke NA, Hiller K, Kremmer E, Wefers B, Wurst W, Sperandio M, Ruland J, Fröhlich T, Hornung V.   +17 more
europepmc   +1 more source