Results 41 to 50 of about 401,055 (285)

Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle [PDF]

, 2014
Inflammation is the ultimate response to the constant challenges of the immune system by microbes, irritants or injury. The inflammatory cascade initiates with the recognition of microorganism-derived pathogen associated molecular patterns (PAMPs) and ...
Abe, Alexeyev, Andersson, Andersson, Ba, Babior, Bartoloni, Berger, Blyth, Brill, Brinkmann, Cadet, Collins, Cooke, Csanád Z. Bachrati, David, Ding, Dostert, Ermakov, Ermakov, Ferguson, Fuchs, Gahan, Gedik, Gehrke, Hajizadeh, Halle, Hiramoto, Huang, Huang, Huang, Huttunen, Ishikawa, Ivana, Ivanov, Jahr, Jia, Kang, Kanneganti, Kazak, Klebanoff, Knaapen, Kondo, Kostyuk, Kostyuk, Krieg, Kuechle, Lane, Lange, Latz, Li, Malins, Mariathasan, Munoz-Gamez, Nakahira, Oka, Pacher, Parvatiyar, Pasheva, Pinti, Polk, Rathinam, Saitoh, Saxena, Scaffidi, Schroder, Shimada, Shokolenko, Sun, Suter, Suzuki, Swindall, Tadie, Taguchi, Takeda, Takeda, Tang, Tang, Thomson, Timea Pálmai-Pallag, Unterholzner, Urbonaviciute, Venereau, Volcic, Weinberg, Weiss, Wilson, Wu, Yan, Yang, Yoshida, Yoshihara, Yotsumoto, You, Yousefi, Zhang, Zhang, Zhang, Zhang, Zhang, Zhou   +100 more
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Interaction of Pattern Recognition Receptors with Mycobacterium Tuberculosis. [PDF]

, 2015
Tuberculosis (TB) is considered a major worldwide health problem with 10 million new cases diagnosed each year. Our understanding of TB immunology has become greater and more refined since the identification of Mycobacterium tuberculosis (MTB) as an ...
A Aderem, A Azzurri, A Bafica, A Kumar, A Mantovani, AB Kamath, AC Ogus, AG Bean, Ali Akbar Velayati, B Abel, B Albiger, B Bottazzi, BB Mishra, BE Schneider, C Garlanda, C Garlanda, C Nathan, C Picard, CA Dinarello, CA Scanga, CC Khor, CH Ladel, CM Fremond, CM Fremond, D Biswas, D Castaño, D Kebir El, Davood Mansouri, DG Souza, DM Underhill, DR Andrade Jr, DR Velez, E Giacomini, E Kay, E Lorenz, E Meylan, E Mortaz, E Torrado, EA Kurt-Jones, EK Jo, Esmaeil Mortaz, F Breviario, F Martinon, G Courtois, G Fenhalls, GA Rook, GW Lee, GW Lee, GY Chen, H Hemmi, H Kumar, H Kumar, H Yamada, HM Lee, I Sugawara, Ian M. Adcock, IC Koo, J Branger, J Bustamante, J Chan, J Kleinnijenhuis, J Kleinnijenhuis, J Kluijver de, J Zuñiga, JC Mak, Jean-Laurent Casanova, JJ Yim, JL Casanova, JP Ting, JS Beckman, K Happel, K Takeda, KD Mayer-Barber, L Alexopoulou, L Gan, L Pompei, LA Pinxteren Van, LG Montgomery, M Gurumurthy, M Introna, M Songane, M Zhang, MB Drennan, MG Drage, MJ Ma, MJ Newport, MM Hossain, Mohammad Reza Masjedi, N Najmi, N Reiling, N Reiling, NC Arbour, NT Thuong, O Takeuchi, P Fietta, P Hartmann, P Selvaraj, P Ye, P Ye, Payam Tabarsi, Peter J. Barnes, R Bryk, R Crevel Van, R Döffinger, R Medzhitov, R Olesen, RC Langen, S Ahmad, S Akira, S Akira, S Akira, S Akira, S Cui, S Davila, S Mariathasan, S Nakae, S Shi, SA Khader, SA Khader, SF Azfar, SL Doyle, SR Krutzik, SS Master, T Kawai, T Kawai, T Kawai, T Ulrichs, TJ Kang, TK Means, TK Means, TM Wozniak, V Quesniaux, V Vouret-Craviari, Y Bulut, Y Liu, Y Xue, Y Zhang   +136 more
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Pattern recognition receptors as potential therapeutic targets in inflammatory rheumatic disease [PDF]

, 2015
The pattern recognition receptors of the innate immune system are part of the first line of defence against pathogens. However, they also have the ability to respond to danger signals that are frequently elevated during tissue damage and at sites of ...
A Baroja-Mazo, A Kuznik, A Lartigue, A Nair, A Yarilina, AM Piccinini, C Jiang, C Jin, C Ospelt, CL Baumann, CM Burns, CM Wang, CR Scanzello, CR Scanzello, D Jiang, D Loeuille, D Tang, DE Macfarlane, DH Kono, DH Sohn, DJ Connolly, E Latz, E Savarese, E Seki, F Brentano, F Hu, F Martinon, F Martinon, FG Goh, G Barreto, G Obermoser, Giselle Chamberlain, H Bernuth von, H Wardemann, HK Lee, HO Sweet, HS Youn, HY Yang, J Choi, JE Molineros, K Bobacz, K Midwood, K Neumann, K Oelke, K Schroder, K Yokota, L Bacconnier, L Sun, LA O'Neill, LE Munoz, Lisa M Mullen, LV Walle, M Carrion, M Feldmann, M Nakashima, MC Boissier, MF Roelofs, ML Santiago-Raber, ND Chamberlain, O Alvarez-Garcia, P Emery, PA Gibilisco, PS Chockalingam, PW Noble, R Baccala, R Liu-Bryan, R Liu-Bryan, R Thwaites, RC Coll, RM Pope, S Abdollahi-Roodsaz, S Abdollahi-Roodsaz, S Abdollahi-Roodsaz, S Alzabin, S Nasi, S Rakoff-Nahoum, SA Schattgen, Sandra Sacre, SL Su, SM Sacre, SM Sacre, SN Ultaigh, SY Chen, SY Lee, T Dorner, T Kawai, T Misawa, TB Geijtenbeek, TB Niewold, TH Mogensen, TH Tran, V Gagne, W Zhang, W Zhang, WJ McCormack, X Chevalier, Y Zhong   +96 more
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Primary immunodeficiencies of pattern recognition receptors [PDF]

Journal of Internal Medicine, 2012
AbstractPrimary immunodeficiencies (PIDs) are severe defects in the capacity of the host to mount a proper immune response, and are characterized by an increased susceptibility to infections. Although classical immunodeficiencies have been characterized based on broad defects in cell populations (e.g.
Netea, M.G., van de Veerdonk, F.L., Meer, J.W.M. van der   +2 more
openaire   +3 more sources

Pattern-recognition receptors in airway inflammation [PDF]

, 2011
Airway inflammation is a defining feature of allergic rhinitis and asthma. Bacterial and viral infections are known to cause exacerbations of both diseases, but knowledge about the mechanisms involved is limited. The pattern-recognition receptors (PRRs)
Ekman, Anna-Karin
core   +1 more source

cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4) [PDF]

, 2011
The RIP kinases have emerged as essential mediators of cellular stress that integrate both extracellular stimuli emanating from various cell-surface receptors and signals coming from intracellular pattern recognition receptors.
Bertrand, Mathieu, Lippens, Saskia, Staes, An, Gilbert, Barbara, Roelandt, Ria, De Medts, Jelle, Gevaert, Kris, Declercq, Wim, Vandenabeele, Peter   +8 more
core   +5 more sources

Identifying the Patterns of Pattern Recognition Receptors [PDF]

Immunity, 2018
Intestinal homeostasis requires microbial recognition that results in appropriate responses to commensals and pathogens. In this issue of Immunity, Price et al. (2018) map the in vivo expression of five toll-like receptors (TLR) in intestinal epithelia, revealing distinct spatio-temporal expression patterns that shape responses to TLR ligands.
Andrea A, Hill, Gretchen E, Diehl
openaire   +2 more sources

Reformulating Pro-Oxidant Microglia in Neurodegeneration [PDF]

, 2019
In neurodegenerative diseases, microglia-mediated neuroinflammation and oxidative stress are central events. Recent genome-wide transcriptomic analyses of microglial cells under different disease conditions have uncovered a new subpopulation named ...
Alonso Bellido, Isabel María, Burguillos García, Miguel Ángel, Cruz Hernández, Luis, Espinosa Oliva, Ana María, García Domínguez, Irene, García Revilla, Juan, Herrera Carmona, Antonio José, Martínez de Pablos, Rocío, Roca Ceballos, María Angustias, Rodríguez Gómez, José Antonio, Ruiz Laza, Rocío, Santiago Pavón, Martiniano, Sarmiento Soto, Manuel, Venero Recio, José Luis   +13 more
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Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'. [PDF]

, 2011
Innate immune cells must be able to distinguish between direct binding to microbes and detection of components shed from the surface of microbes located at a distance. Dectin-1 (also known as CLEC7A) is a pattern-recognition receptor expressed by myeloid
AM Kerrigan, AM Kerrigan, Andrea J. Wolf, Andrew S. Magee, Anissa S. H. Chan, Arthur Weiss, B Ferwerda, BN Gantner, Christopher N. Reyes, Courtney A. Becker, D Feng, David M. Underhill, DM Underhill, DR Fooksman, EL Adams, GD Brown, GD Brown, GL Fuller, Helen S. Goodridge, HS Goodridge, HS Goodridge, HS Goodridge, J Lin, JK Czop, John P. Vasilakos, Jun Ma, JW Zhu, KM Dennehy, LM Lavigne, Michael E. Danielson, MJ Robinson, ML Hermiston, Nandita Bose, PR Taylor, S Saijo, Tamiko R. Katsumoto, TS Plantinga   +36 more
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Phosphorylation is required for the pathogen defense function of the Arabidopsis PEN3 ABC transporter. [PDF]

, 2017
The Arabidopsis PEN3 ABC transporter accumulates at sites of pathogen detection, where it is involved in defense against a number of pathogens. Perception of PAMPs by pattern recognition receptors initiates recruitment of PEN3 and also leads to PEN3 ...
Somerville, Shauna, Underwood, William
core   +1 more source