Results 171 to 180 of about 861,453 (229)

Visualising pattern recognition receptor signalling

Biochemical Society Transactions, 2017
Signalling by pattern recognition receptors (PRRs) is critical for protecting the host against pathogens. Disruption of these signalling pathways has been implicated in many diseases ranging from infection susceptibility to cancer and autoimmune disease.
Charlotte, Macleod, Clare E, Bryant
openaire   +3 more sources

The crosstalk between pattern-recognition receptor signaling and calcium signaling.

International Journal of Biological Macromolecules, 2021
The innate immune system is the first line of host defense, and it is capable of resisting both exogenous pathogenic challenges and endogenous danger signals via different pattern recognition receptors (PRRs), including Toll-like receptors, retinoic acid-
Fanyun Kong, Hongjuan You, Kuiyang Zheng, Renxian Tang, C. Zheng   +4 more
semanticscholar   +1 more source

Pattern recognition receptor‐mediated inflammation in diabetic vascular complications

Medicinal research reviews (Print), 2020
The innate immune system contains multiple classes of pattern recognition receptors (PRRs), which recognize pathogen‐associated molecular patterns (PAMPs) and danger‐associated molecular patterns (DAMPs) in the intracellular and extracellular space ...
Xu Wang, Victor Antony, Yi Wang, Gaojun Wu, G. Liang   +4 more
semanticscholar   +1 more source

Pattern recognition receptors in annelids

Developmental & Comparative Immunology, 2020
The existence of pattern recognition receptors (PRRs) on immune cells was discussed in 1989 by Charles Janeway, Jr., who proposed a general concept of the ability of PRRs to recognize and bind conserved molecular structures of microorganisms known as pathogen-associated molecular patterns (PAMPs).
Prochazkova, P., Roubalova, R., Dvorak, J., Navarro Pacheco, N.I., Bilej, M.   +4 more
openaire   +2 more sources

Pattern recognition receptors: an update

Expert Review of Clinical Immunology, 2006
The vertebrate immune system consists of two inter-related components, the innate and adaptive responses, which are required for the resolution of infection. The innate immune response is critical for the immediate protection from infection and for marshalling the B- and T-cell responses of the adaptive response.
Goutagny, Nadege, Fitzgerald, Katherine A   +1 more
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Pattern Recognition Receptors and Liver Failure

Critical Reviews in Immunology, 2019
Liver failure is a clinical syndrome with many causes, a complicated pathogenesis, diverse clinical manifestations, and very high mortality. No effective treatment is yet available. Main pathological processes of liver failure include direct damage to parenchymal and nonparenchymal liver cells that might be caused by viruses or drugs, immune-mediated ...
Wu, Jun, Han, Meihong, Li, Jia, Yang, Xiaoli, Zhen, Xin, Friedrich Schlaak, Joerg, Yang, Dongliang, Lu, Mengji   +7 more
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Antiviral Signaling Through Pattern Recognition Receptors

Journal of Biochemistry, 2006
Viral infection is detected by the host innate immune system. Innate immune cells such as dendritic cells and macrophages detect nucleic acids derived from viruses through pattern recognition receptors (PRRs). Viral recognition by PRRs initiates the activation of signaling pathways that lead to production of type I interferon and inflammatory cytokines,
Taro, Kawai, Shizuo, Akira
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Pattern recognition receptor function in neutrophils

Trends in Immunology, 2013
Previously, neutrophils were largely ignored in the pattern recognition receptor (PRR) signaling field. However, interest in neutrophil biology has been revitalized by emerging roles for neutrophils in promoting protective and pathogenic T helper (Th)17-driven immune responses and in orchestrating innate and adaptive immunity via cytokine/chemokine ...
Thomas, Christina J., Schroder, Kate
openaire   +3 more sources