Evolutionary gain and loss of a plant pattern-recognition receptor for HAMP recognition [PDF]
eLife, 2022 As a first step in innate immunity, pattern recognition receptors (PRRs) recognize the distinct pathogen and herbivore-associated molecular patterns and mediate activation of immune responses, but specific steps in the evolution of new PRR sensing ...
Simon Snoeck +5 more
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Exploration of Pattern Recognition Receptor Agonists as Candidate Adjuvants [PDF]
Frontiers in Cellular and Infection Microbiology, 2021 Adjuvants are used to maximize the potency of vaccines by enhancing immune reactions. Components of adjuvants include pathogen-associated molecular patterns (PAMPs) and damage-associate molecular patterns (DAMPs) that are agonists for innate immune ...
Guang Han Ong +3 more
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Regulation of pattern recognition receptor signaling by palmitoylation [PDF]
iScienceSummary: Pattern recognition receptors (PRRs), consisting of Toll-like receptors, RIG-I-like receptors, cytosolic DNA sensors, and NOD-like receptors, sense exogenous pathogenic molecules and endogenous damage signals to maintain physiological ...
Xiaocui Li +5 more
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Pattern recognition receptor ligand-induced differentiation of human transitional B cells. [PDF]
PLoS ONE, 2022 B cells represent a critical component of the adaptive immune response whose development and differentiation are determined by antigen-dependent and antigen-independent interactions.
Jourdan K P McMillan +2 more
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Genotyping-by-sequencing-based identification of Arabidopsis pattern recognition receptor RLP32 recognizing proteobacterial translation initiation factor IF1 [PDF]
Nature Communications, 2022 Pattern-triggered immunity is activated by recognition of microbe-derived structures by host pattern recognition receptors. Here the authors use a genotype-by sequencing approach to show that bacterial translation initiation factor 1 triggers PTI in ...
Li Fan +15 more
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The activating receptor NKG2D is an anti-fungal pattern recognition receptor [PDF]
Nature CommunicationsNKG2D is a central activating receptor involved in target recognition and killing by Natural Killer and CD8+ T cells. The known role of NKG2D is to recognize a family of self-induced stress ligands that are upregulated on stressed cells such as cancerous
Yoav Charpak-Amikam +11 more
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Pattern recognition receptor signaling and innate immune responses to schistosome infection [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Schistosomiasis remains to be a significant public health problem in tropical and subtropical regions. Despite remarkable progress that has been made in the control of the disease over the past decades, its elimination remains a daunting challenge in ...
Nouhoum Dibo +6 more
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Pattern recognition receptor agonists in pathogen vaccines mediate antitumor T-cell cross-priming [PDF]
Journal for ImmunoTherapy of Cancer, 2023 Background Cancer immunotherapies are generally effective in patients whose tumors contain a priori primed T-cells reactive to tumor antigens (TA).
Michael Yellin +13 more
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The Emerging Roles of Pellino Family in Pattern Recognition Receptor Signaling [PDF]
Frontiers in Immunology, 2022 The Pellino family is a novel and well-conserved E3 ubiquitin ligase family and consists of Pellino1, Pellino2, and Pellino3. Each family member exhibits a highly conserved structure providing ubiquitin ligase activity without abrogating cell and ...
E Zhang, Xia Li, Xia Li
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Dynamin-Related Proteins Enhance Tomato Immunity by Mediating Pattern Recognition Receptor Trafficking [PDF]
Membranes, 2022 Pattern recognition receptor (PRR) trafficking to the plasma membrane and endocytosis plays a crucial role in pattern triggered immunity (PTI). Dynamin-related proteins (DRPs) participate in endocytosis and recycling.
Meirav Leibman-Markus +5 more
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