Results 21 to 30 of about 246,190 (254)
Pattern Recognition Receptors in HIV Transmission [PDF]
Frontiers in Immunology, 2012 Dendritic cells (DCs), Langerhans cells (LCs), and macrophages are innate immune cells that reside in genital and intestinal mucosal tissues susceptible to HIV-1 infection. These innate cells play distinct roles in initiation of HIV-1 infection and induction of anti-viral immunity. DCs are potent migratory cells that capture HIV-1 and transfer virus to
Mesman, Annelies W. +1 more
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Frontiers in Immunology, 2023 Surgery or radiation therapy is nearly universally applied for pediatric solid tumors. In many cases, in diverse tumor types, distant metastatic disease is present and evades surgery or radiation.
Emily P. Vonderhaar +7 more
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Cellular and Molecular Gastroenterology and Hepatology, 2022 Background and aims: C-reactive protein (CRP) is a hepatocyte-produced marker of inflammation yet with undefined function in liver injury. We aimed to examine the role of CRP in acetaminophen-induced liver injury (AILI).
Hai-Yun Li +9 more
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Pattern-Recognition Receptors and Gastric Cancer [PDF]
Frontiers in Immunology, 2014 Chronic inflammation has been associated with an increased risk of several human malignancies, a classic example being gastric adenocarcinoma (GC). Development of GC is known to result from infection of the gastric mucosa by Helicobacter pylori, which initially induces acute inflammation and, in a subset of patients, progresses over time to chronic ...
Castaño-Rodríguez, N +2 more
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Pattern recognition receptors in health and diseases [PDF]
Signal Transduction and Targeted Therapy, 2021 AbstractPattern recognition receptors (PRRs) are a class of receptors that can directly recognize the specific molecular structures on the surface of pathogens, apoptotic host cells, and damaged senescent cells. PRRs bridge nonspecific immunity and specific immunity.
Danyang Li, Minghua Wu
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MLKL Compromises Plasma Membrane Integrity by Binding to Phosphatidylinositol Phosphates
Cell Reports, 2014 Although mixed lineage kinase domain-like (MLKL) protein has emerged as a specific and crucial protein for necroptosis induction, how MLKL transduces the death signal remains poorly understood.
Yves Dondelinger +15 more
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Cells, 2021 Acute pancreatitis (AP) is a severe and potentially fatal disease caused predominantly by alcohol excess and gallstones, which lacks a specific therapy.
Yulin Ouyang +13 more
doaj +1 more source
Cell Reports, 2017 Receptor interacting protein kinase 3 (RIPK3) induces necroptosis, a type of regulated necrosis, through its kinase domain and receptor interacting protein (RIP) homotypic interaction motif (RHIM).
Kenta Moriwaki +4 more
doaj +1 more source
Cell Reports, 2016 Microvascular endothelial cells maintain a tight barrier to prevent passage of plasma and circulating immune cells into the extravascular tissue compartment, yet endothelial cells respond rapidly to vasoactive substances, including thrombin, allowing ...
Linda R. Klei +18 more
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Molecular Plant-Microbe Interactions, 2023 Plants rely on innate immune systems to defend against a wide variety of biotic attackers. Key components of innate immunity include cell-surface pattern-recognition receptors (PRRs), which recognize pest- and pathogen-associated molecular patterns ...
Anthony G. K. Garcia +1 more
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