Results 11 to 20 of about 246,190 (254)
Inflammasome-Associated Gastric Tumorigenesis Is Independent of the NLRP3 Pattern Recognition Receptor [PDF]
Frontiers in Oncology, 2022 Inflammasomes are important multiprotein regulatory complexes of innate immunity and have recently emerged as playing divergent roles in numerous inflammation-associated cancers.
Alice J. West +12 more
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Pattern recognition receptor signaling in otitis media: immune crosstalk and pathogenic mechanisms [PDF]
Frontiers in ImmunologyOtitis media (OM) remains a prevalent and multifactorial inflammatory disease of the middle ear, especially in pediatric populations. The immune system, particularly pattern recognition receptors (PRRs), plays a central role in detecting microbial ...
Mingwen Guo +5 more
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Cnidarian Pattern Recognition Receptor Repertoires Reflect Both Phylogeny and Life History Traits [PDF]
Frontiers in Immunology, 2021 Pattern recognition receptors (PRRs) are evolutionarily ancient and crucial components of innate immunity, recognizing danger-associated molecular patterns (DAMPs) and activating host defenses.
Madison A. Emery +2 more
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Pattern Recognition Receptors and Autophagy [PDF]
Frontiers in Immunology, 2014 The immune system senses exogenous threats or endogenous stress through specialized machinery known as pattern recognition receptors (PRRs). These receptors recognize conserved molecular structures and initiate downstream signaling pathways to control immune responses.
Oh, JE Oh, Ji Eun +1 more
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Inhibitory pattern recognition receptors
Journal of Experimental Medicine, 2021 Pathogen- and damage-associated molecular patterns are sensed by the immune system’s pattern recognition receptors (PRRs) upon contact with a microbe or damaged tissue. In situations such as contact with commensals or during physiological cell death, the immune system should not respond to these patterns.
Matevž Rumpret +3 more
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Pattern Recognition Receptors and Inflammation [PDF]
Cell, 2010 Infection of cells by microorganisms activates the inflammatory response. The initial sensing of infection is mediated by innate pattern recognition receptors (PRRs), which include Toll-like receptors, RIG-I-like receptors, NOD-like receptors, and C-type lectin receptors.
Takeuchi, Osamu, Akira, Shizuo
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Japanese Journal of Clinical Immunology, 2011 Immunity is based on self/nonself discrimination. In vertebrates, two major systems, innate and adaptive immune systems, constitute host defense against invading microbes. Adaptive immunity is characterized by specific immune responses through B- or T-cell antigen receptors that are generated by somatic recombination, whereas nonspecific responses to ...
Takaya, Hayashi +2 more
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Avian Pattern Recognition Receptor Sensing and Signaling
Veterinary Sciences, 2020 Pattern recognition receptors (PRRs) are a class of immune sensors that play a critical role in detecting and responding to several conserved patterns of microorganisms.
Sabari Nath Neerukonda, Upendra Katneni
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Coronaviral Infection and Interferon Response: The Virus-Host Arms Race and COVID-19
Viruses, 2022 The recent pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in unprecedented morbidity and mortality worldwide.
Qi Liu +4 more
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The innate immune receptor Nlrp12 suppresses autoimmunity to the retina
Journal of Neuroinflammation, 2022 Background Nod-like receptors (NLRs) are critical to innate immune activation and induction of adaptive T cell responses. Yet, their role in autoinflammatory diseases of the central nervous system (CNS) remains incompletely defined.
Ellen J. Lee +6 more
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