Results 31 to 40 of about 246,190 (254)

Human Dectin-1 is O-glycosylated and serves as a ligand for C-type lectin receptor CLEC-2

eLife, 2022
C-type lectin receptors (CLRs) elicit immune responses upon recognition of glycoconjugates present on pathogens and self-components. While Dectin-1 is the best-characterized CLR recognizing β-glucan on pathogens, the endogenous targets of Dectin-1 are ...
Shojiro Haji, Taiki Ito, Carla Guenther, Miyako Nakano, Takashi Shimizu, Daiki Mori, Yasunori Chiba, Masato Tanaka, Sushil K Mishra, Janet A Willment, Gordon D Brown, Masamichi Nagae, Sho Yamasaki   +12 more
doaj   +1 more source

Pattern recognition receptors in microbial keratitis [PDF]

Eye, 2015
Microbial keratitis is a significant cause of global visual impairment and blindness. Corneal infection can be caused by a wide variety of pathogens, each of which exhibits a range of mechanisms by which the immune system is activated. The complexity of the immune response to corneal infection is only now beginning to be elucidated.
Taube, M.A., Del Mar Cendra, M., Elsahn, A., Christodoulides, Myron, Hossain, Parwez   +4 more
openaire   +3 more sources

Pattern recognitions receptors in immunodeficiency disorders [PDF]

European Journal of Pharmacology, 2017
Pattern recognition receptors (PRRs) recognize common microbial or host-derived macromolecules and have important roles in early activation and response of the immune system. Initiation of the innate immune response starts with the recognition of microbial structures called pathogen associated molecular patterns (PAMPs).
Mortaz, E, Adcock, IM, Tabarsi, P, Darazam, IA, Movassaghi, M, Garssen, J, Jamaati, H, Velayati, A   +7 more
openaire   +4 more sources

Galectin-1 from redlip mullet Liza haematocheilia: identification, immune responses, and functional characterization as pattern recognition receptors (PRRs) in host immune defense system

Fisheries and Aquatic Sciences, 2022
Galectins, a family of β-galactoside-binding lectins, have emerged as soluble mediators in infected cells and pattern recognition receptors (PRRs) responsible for evoking and regulating innate immunity.
Chaehyeon Lim, Hyukjae Kwon, Jehee Lee
doaj   +1 more source

Intracellular pattern-recognition receptors☆

Advanced Drug Delivery Reviews, 2008
The last ten years of research in the field of innate immunity have been incredibly fertile: the transmembrane Toll-like receptors (TLRs) were discovered as guardians protecting the host against microbial attacks and the emerging pathways characterized in detail.
DOSTERT, C, Meylan, Etienne, Tschopp, J
openaire   +4 more sources

RIG-I: a multifunctional protein beyond a pattern recognition receptor

Protein & Cell, 2017
It was widely known that retinoic acid inducible gene I (RIG-I) functions as a cytosolic pattern recognition receptor that initiates innate antiviral immunity by detecting exogenous viral RNAs.
Xiao-xiao Xu, Han Wan, Li Nie, Tong Shao, Li-xin Xiang, Jian-zhong Shao   +5 more
doaj   +1 more source

Primary immunodeficiencies of pattern recognition receptors [PDF]

Journal of Internal Medicine, 2012
AbstractPrimary immunodeficiencies (PIDs) are severe defects in the capacity of the host to mount a proper immune response, and are characterized by an increased susceptibility to infections. Although classical immunodeficiencies have been characterized based on broad defects in cell populations (e.g.
Netea, M.G., van de Veerdonk, F.L., Meer, J.W.M. van der   +2 more
openaire   +3 more sources

Identifying the Patterns of Pattern Recognition Receptors [PDF]

Immunity, 2018
Intestinal homeostasis requires microbial recognition that results in appropriate responses to commensals and pathogens. In this issue of Immunity, Price et al. (2018) map the in vivo expression of five toll-like receptors (TLR) in intestinal epithelia, revealing distinct spatio-temporal expression patterns that shape responses to TLR ligands.
Andrea A, Hill, Gretchen E, Diehl
openaire   +2 more sources

Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis.

PLoS Pathogens, 2008
Candida albicans is a medically important pathogen, and recognition by innate immune cells is critical for its clearance. Although a number of pattern recognition receptors have been shown to be involved in recognition and phagocytosis of this fungus ...
Sigrid E M Heinsbroek, Philip R Taylor, Fernando O Martinez, Luisa Martinez-Pomares, Gordon D Brown, Siamon Gordon   +5 more
doaj   +1 more source

Feasibility of Applying Helper-Dependent Adenoviral Vectors for Cancer Immunotherapy

Biomedicines, 2014
Adenoviruses (Ads) infect a broad range of tissue types, and derived vectors have been extensively used for gene therapy. Helper-dependent Ad vectors (HDAds), devoid of viral coding sequences, allow for insertion of large or multiple transgenes in a ...
Lisa M. Farzad, Masataka Suzuki
doaj   +1 more source