Results 151 to 160 of about 188,478 (231)

Sensing danger in the islet: the roles of pattern recognition receptors in β cells and type 1 diabetes. [PDF]

Front Immunol
Tong L, Tu Y, Huang S, Zheng P.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Role of Pattern Recognition Receptors in Epigenetic and Metabolic Reprogramming: Insights into Trained Immunity. [PDF]

J Inflamm Res
Li Y, Chen M, Li J, Hu J.
europepmc   +1 more source

Are Pattern Recognition Receptors Associated with Hepatocellular Carcinoma? [PDF]

Turk J Gastroenterol, 2021
Dertli R, Asil M, Bıyık M, Karakarcayıldız A, Keskin M, Kayar Y, Başdemirci M, Ataseven H.   +7 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Introducing Pattern Recognition Receptors in Potato Confers Enhanced Resistance to Ralstonia solanacearum but Not a Vector Borne Pathogen. [PDF]

Plant Biotechnol J
Li T, Meira FS, Jarquin Bolaños E, Guel B, Padilla CS, Mandadi KK, Thomson JG, Ranf S, Coaker G.   +8 more
europepmc   +1 more source

Convergent evolution of plant pattern recognition receptors sensing cysteine-rich patterns from three microbial kingdoms. [PDF]

Nat Commun, 2023
Yang Y, Steidele CE, Rössner C, Löffelhardt B, Kolb D, Leisen T, Zhang W, Ludwig C, Felix G, Seidl MF, Becker A, Nürnberger T, Hahn M, Gust B, Gross H, Hückelhoven R, Gust AA.   +16 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Sensing of Ebinur Lake virus by distinct pattern recognition receptors dictates cell-type specific innate immunity and pathogenesis. [PDF]

J Virol
Zou J-P, Wang S-Y, Xia H, Xu Z-S, Luo W-W, Wang Y-Y.   +5 more
europepmc   +1 more source

Innate Immunity Crosstalk with Helicobacter pylori: Pattern Recognition Receptors and Cellular Responses. [PDF]

Int J Mol Sci, 2022
Cheok YY, Tan GMY, Lee CYQ, Abdullah S, Looi CY, Wong WF.   +5 more
europepmc   +1 more source