The myogenic transcription factor Pax3 plays an essential role in early skeletal muscle development and is a key factor in Alveolar rhabdomyosarcoma (ARMS), a childhood solid muscle tumor. ARMS is associated with an unfavorable prognosis due to the propensity for wide dissemination and a poor response to ...
Kevin N. Dietz +2 more
openaire +1 more source
Neuroectodermal tumor cells, like neural crest (NC) cells, are pluripotent, proliferative, and migratory. We tested the hypothesis that genetic programs essential to NC development are activated in neuroectodermal tumors.
Timothy R. Gershon +3 more
doaj +1 more source
Generation of both an shRNA-resistant MEF2A over expression construct and a dominant negative construct in adenovirus for rescue and knockout experiments in muscle [PDF]
The Myocyte Enhancer Factor-2, or MEF2, transcription factor family is necessary for the differentiation and regeneration of both skeletal and cardiac muscle tissue.
Comeau, Kathryn Marie
core +1 more source
Prmt5 is a regulator of muscle stem cell expansion in adult mice. [PDF]
Skeletal muscle stem cells (MuSC), also called satellite cells, are indispensable for maintenance and regeneration of adult skeletal muscles. Yet, a comprehensive picture of the regulatory events controlling the fate of MuSC is missing.
Braun, Thomas +7 more
core
Promoter keyholes enable specific and persistent multi-gene expression programs in primary T cells without genome modification [PDF]
Non-invasive epigenome editing is a promising strategy for engineering gene expression programs, yet potency, specificity, and persistence remain challenging.
Acosta, Reyes +25 more
core
Dynamic and non-uniform expression of key transcription factors provides insights into the emergence of neural crest cells at the neural plate border. [PDF]
Montequin A, LaBonne C.
europepmc +1 more source
Vestigial-like 4 Regulates Neurogenesis and Neural Crest Formation During <i>Xenopus</i> Development. [PDF]
Thiébaud P +5 more
europepmc +1 more source
Biological Advances and Current Challenges for Pediatric Rhabdomyosarcoma. [PDF]
Hebron KE +39 more
europepmc +1 more source
Regulation of multiple target genes by miR-1 and miR-206 is pivotal for C2C12 myoblast differentiation [PDF]
Akimoto +51 more
core +1 more source

