Deciphering skeletal muscle development: cellular heterogeneity and molecular regulatory networks from single-cell and spatial transcriptomic perspectives. [PDF]
Front Cell Dev BiolWang X, Zhang Y, Wei H, Zhao G, Mu R.
europepmc +1 more source
Cancer-associated fibroblasts promote tumor progression in fusion-positive rhabdomyosarcoma. [PDF]
Sci RepSipila P +5 more
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Dominant blue eyes in Maine Coon cats: New PAX3 variant and updated phenotypic data. [PDF]
Anim GenetAbitbol M +5 more
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PAX3 Regulatory Signatures and Gene Targets in Melanoma Cells. [PDF]
Genes (Basel)Moore SPG +6 more
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The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx [PDF]
EMBO Journal, 1999 The Pax3-FKHR fusion protein is present in alveolar rhabdomyosarcoma and results from the t(2;13) (q35;q14) chromosomal translocation. Its oncogenic activity is dependent on a combination of protein-DNA and protein-protein interactions mediated by the Pax3 homeodomain recognition helix.
G Grosveld
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Cell-type-specific regulation of distinct sets of gene targets by Pax3 and Pax3/FKHR [PDF]
Oncogene, 2005 The oncogenic fusion protein, Pax3/FKHR, is a more potent transcription factor relative to its normal counterpart, Pax3. Since Pax3 induced a mesenchymal to epithelial transition (MET) in human SaOS-2 osteosarcomas, we hypothesized that Pax3/FKHR would also induce a morphological change in SaOS-2 cells.
Olivia Wilkins, Wilkins Olivia
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PAX3 and PAX3-FKHR promote rhabdomyosarcoma cell survival through downregulation of PTEN
Cancer Letters, 2007PAX3 or PAX3-FKHR expression is implicated in cell transformation and tumourigenesis. Here, C2C12 myoblasts were transfected with a sense Pax3 vector and a pTet-On system to induce Pax3 expression, whereas to downregulate PAX3-FKHR, Rh18 was transfected with an antisense Pax3 with a pTet-On system.
Qiuyu Wang, Mark Slevin, Shant Kumar
exaly +4 more sources
PAX3 and PAX7 as upstream regulators of myogenesis
Seminars in Cell and Developmental Biology, 2015Like other subclasses within the PAX transcription factor family, PAX3 and PAX7 play important roles in the emergence of a number of different tissues during development. PAX3 regulates neural crest and, together with its orthologue PAX7, is also expressed in parts of the central nervous system.
Frédéric Relaix, Margaret Buckingham
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PAX3‐FOXO1 and FGFR4 in alveolar rhabdomyosarcoma
Molecular Carcinogenesis, 2011AbstractWe and others have identified FGFR4 as a direct transcriptional target of the alveolar rhabdomyosarcoma (ARMS) specific fusion protein, PAX3‐FOXO1. We hypothesized fibroblast growth factor receptor 4 (FGFR4) may act as an effector of PAX3‐FOXO1, contributing to PAX3‐FOXO1 tumorigenic phenotypes.
Amy D, Marshall +2 more
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