Results 31 to 40 of about 19,461 (219)
A Pax3/Dmrt2/Myf5 regulatory cascade functions at the onset of myogenesis. [PDF]
PLoS Genetics, 2010 All skeletal muscle progenitor cells in the body derive from the dermomyotome, the dorsal epithelial domain of developing somites. These multipotent stem cells express Pax3, and this expression is maintained in the myogenic lineage where Pax3 plays an ...
Takahiko Sato +4 more
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Essential role for PDGF signaling in ophthalmic trigeminal placode induction [PDF]
, 2008 Much of the peripheral nervous system of the head is derived from ectodermal thickenings, called placodes, that delaminate or invaginate to form cranial ganglia and sense organs.
Bronner-Fraser, Marianne +1 more
core +1 more source
PAX3-FOXO1: Zooming in on an “undruggable” target
Seminars in Cancer Biology, 2018 Driver oncogenes are prime targets for therapy in tumors many of which, including leukemias and sarcomas, express recurrent fusion transcription factors. One specific example for such a cancer type is alveolar rhabdomyosarcoma, which is associated in the majority of cases with the fusion protein PAX3-FOXO1.
Wachtel, Marco, Schäfer, Beat W
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Dissecting early regulatory relationships in the lamprey neural crest gene network [PDF]
, 2008 The neural crest, a multipotent embryonic cell type, originates at the border between neural and nonneural ectoderm. After neural tube closure, these cells undergo an epithelial–mesenchymal transition, migrate to precise, often distant locations, and ...
Basch +22 more
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Pax3 and Hippo Signaling Coordinate Melanocyte Gene Expression in Neural Crest
Cell Reports, 2014 Summary: Loss of Pax3, a developmentally regulated transcription factor expressed in premigratory neural crest, results in severe developmental defects and embryonic lethality.
Lauren J. Manderfield +9 more
doaj +1 more source
Rhabdomyosarcoma: Advances in Molecular and Cellular Biology. [PDF]
, 2015 Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in childhood and adolescence. The two major histological subtypes of RMS are alveolar RMS, driven by the fusion protein PAX3-FKHR or PAX7-FKHR, and embryonic RMS, which is usually ...
Duan, Zhenfeng +5 more
core +3 more sources
PAX3 mutant mesoangioblasts are defective in myogenic differentiation [PDF]
, 2005 .
Sirabella, Dario
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Wnt Signaling in Neural Crest Ontogenesis and Oncogenesis. [PDF]
, 2019 Neural crest (NC) cells are a temporary population of multipotent stem cells that generate a diverse array of cell types, including craniofacial bone and cartilage, smooth muscle cells, melanocytes, and peripheral neurons and glia during embryonic ...
Hao, Hongyan +4 more
core +2 more sources
PAX3‐FOXO1 Directed Transcriptional Activation is Mediated by PAX3 and FOXO1 Recognition Sequences
The FASEB Journal, 2015 Alveolar Rhabdomyosarcoma (ARMS) patients carrying a chromosomal translocation of PAX3 and FOXO1 have the highest mortality rates, indicating the importance of understanding how this transcription ...
Tess Cherlin +2 more
openaire +1 more source
BMC Cancer, 2012 Background Alveolar rhabdomyosarcoma (ARMS) has a high propensity to metastasize, leading to its aggressiveness and a poor survival rate among those with the disease. More than 80% of aggressive ARMSs harbor a PAX3-FKHR fusion transcription factor, which
Liu Lingling +4 more
doaj +1 more source