Results 11 to 20 of about 8,131 (149)
Effect of induced diabetes on morphometric indexes of the cerebellar cortex and gene expression in C57BL mice [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): Diabetes is a metabolic disorder that affects the development of the central nervous system and plays an important role in learning and memory.
Somayeh Sharifi +4 more
doaj +1 more source
Pax7 remodels the chromatin landscape in skeletal muscle stem cells. [PDF]
PLoS ONE, 2017 Pluripotent stem cells (PSC) hold great promise for the treatment of human skeletal muscle diseases. However, it remains challenging to convert PSC to skeletal muscle cells, and the mechanisms by which the master regulatory transcription factor, Pax7 ...
Karin C Lilja +9 more
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STAR Protocols, 2020 Summary: This protocol describes the use of CRISPR/Cas9-mediated homology-directed recombination to construct a PAX7-GFP reporter in human pluripotent stem cells (hPSCs). PAX7 is a key transcription factor and regulator of skeletal muscle stem/progenitor
Haibin Xi +2 more
doaj +1 more source
Cells, 2021 PAX7 transcription factor plays a crucial role in embryonic myogenesis and in adult muscles in which it secures proper function of satellite cells, including regulation of their self renewal.
Anita Florkowska +8 more
doaj +1 more source
Pioneer and nonpioneer factor cooperation drives lineage specific chromatin opening
Nature Communications, 2019 Pioneer transcription factor Pax7 specifies melanotrope cells, which then allows for the binding of Tpit transcription factor. Here, authors find that while binding of heterochromatin targeting by Pax7 is independent of Tpit, Pax7-dependent chromatin ...
Alexandre Mayran +7 more
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Nature Communications, 2021 PTEN copy number loss is found in 25% of fusion-negative rhabdomyosarcomas (FN-RMS). Here, the authors use a Hedgehog-driven FN-RMS mouse model to show that PTEN loss drives the expression of core transcription factor PAX7 and its transcriptional axis ...
Casey G. Langdon +14 more
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Stem Cell Research & Therapy, 2020 Background Pluripotent stem cells present the ability to self-renew and undergo differentiation into any cell type building an organism. Importantly, a lot of evidence on embryonic stem cell (ESC) differentiation comes from in vitro studies.
Anita Florkowska +8 more
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MLL1 is required for PAX7 expression and satellite cell self-renewal in mice
Nature Communications, 2019 PAX7 transcription factor specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation.
Gregory C. Addicks +7 more
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Cell Reports, 2016 Pax7 is a nodal transcription factor that is essential for regulating the maintenance, expansion, and myogenic identity of satellite cells during both neonatal and adult myogenesis.
Alessandra Pasut +7 more
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Human muscle-derived CLEC14A-positive cells regenerate muscle independent of PAX7
Nature Communications, 2019 Skeletal muscle stem cells express the transcription factor Pax7. Here, the authors isolate, from human muscle, cells that are positive for the endothelial marker CLEC14A and show that despite not expressing pax7, these cells regenerate muscle and ...
Andreas Marg +21 more
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