Results 41 to 50 of about 8,131 (149)

Regulation of Pax7 protein levels by caspase-3 and proteasome activity in differentiating myoblasts

Biological Research, 2011
The transcription factor Pax7 negatively regulates the activity of the muscle regulatory transcription factor MyoD, preventing muscle precursor cells from undergoing terminal differentiation.
Hugo C Olguín
doaj  

A robust Pax7EGFP mouse that enables the visualization of dynamic behaviors of muscle stem cells

Skeletal Muscle, 2018
Background Pax7 is a transcription factor involved in the specification and maintenance of muscle stem cells (MuSCs). Upon injury, MuSCs leave their quiescent state, downregulate Pax7 and differentiate, contributing to skeletal muscle regeneration.
Elisia D. Tichy, David K. Sidibe, Christopher D. Greer, Nicholas M. Oyster, Panteleimon Rompolas, Nadia A. Rosenthal, Helen M. Blau, Foteini Mourkioti   +7 more
doaj   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Metformin alleviates muscle wasting post-thermal injury by increasing Pax7-positive muscle progenitor cells

Stem Cell Research & Therapy, 2020
Background Profound skeletal muscle wasting and weakness is common after severe burn and persists for years after injury contributing to morbidity and mortality of burn patients.
Yusef Yousuf, Andrea Datu, Ben Barnes, Saeid Amini-Nik, Marc G. Jeschke   +4 more
doaj   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

Additional file 5: Figure S5. of Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures

, 2017
DUX4 is not expressed in PAX7 positive myocytes in hiPSC-mosaic 2 with the long D4Z4 array. A and B) Images of hiPSC-mosaic 2 long myocytes from D40 of the differentiation protocol stained with antibodies to both PAX7 and DUX4 and utilized to quantify the number of DUX4 and PAX7 positive cells. (DOCX 1755 kb)
Premi Haynes, Kernan, Kelly, Suk-Lin Zhou, Miller, Daniel   +3 more
openaire   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

Abstract 028 | Modelling satellite cell dysfunction to understand pathogenesis of neuromuscular disorders

European Journal of Translational Myology
Muscle maintenance and regeneration depend on satellite cells, the resident stem cells of skeletal muscle. Impaired satellite cell function is increasingly recognized as a key contributor to many neuromuscular disorders.
Massimo Ganassi
doaj   +1 more source

Additional file 7: Figure S7. of Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures

, 2017
DUX4 is not expressed in PAX7 positive myocytes in control human ES cells. A and B) Images of hESC-cntrl myocytes from D40 of the differentiation protocol stained with antibodies to both PAX7 and DUX4 and utilized to quantify the number of DUX4 and PAX7 positive cells. (DOCX 1665 kb)
Premi Haynes, Kernan, Kelly, Suk-Lin Zhou, Miller, Daniel   +3 more
openaire   +1 more source

The Impact of Ageing on Skeletal Muscle: Roles of Mitochondrial Dysregulation, Systemic Communication, and Exercise

Journal of Cellular Physiology, Volume 241, Issue 8, August 2026.
ABSTRACT Ageing is a major risk factor for degenerative diseases, including sarcopenia, which is characterized by a progressive loss of skeletal muscle mass and function, frailty, and is associated with increased mortality. Skeletal muscle regeneration relies on muscle stem cells and efficient communication with cellular microenvironment.
Juan Diego Hernández‐Camacho, Marielle Saclier   +1 more
wiley   +1 more source