Results 31 to 40 of about 8,131 (149)

Additional file 6: Figure S6. of Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures

, 2017
DUX4 and PAX7 are expressed in distinct cell types during myogenic differentiation of hiPSC-mosaic 2 with the short D4Z4 array. A, B, C, D and E) Images of hiPSC-mosaic 2 with the short D4Z4 array from D40 of the differentiation protocol stained with antibodies to both PAX7 and DUX4. Arrows indicate representative DUX4 positive nuclei counted.
Premi Haynes, Kernan, Kelly, Suk-Lin Zhou, Miller, Daniel   +3 more
openaire   +1 more source

Multifunctional hyaluronic acid hydrogel integrating exosome‐encapsulating gelatin microspheres accelerates skeletal muscle regeneration via TGF‐β1 activation and enhanced myogenic cell viability

BMEMat, EarlyView.
Schematic illustration of preparation of injectable H/G@Co@miR‐206 hydrogel for efficient skeletal muscle regeneration in cardiotoxin‐induced skeletal muscle injury SD rat model. Abstract The effective treatment of acute skeletal muscle injuries remains challenging, necessitating therapeutic strategies that concurrently reestablish vascular perfusion ...
Zhengzhe Han, Zongyue Li, Ang Li, Zheng Jiang, Saiyu Shi, Zhipeng Wang, Jishizhan Chen, Yun Qian, Yuanyang Gu, Xianyou Zheng   +9 more
wiley   +1 more source

PAX7 target genes are globally repressed in facioscapulohumeral muscular dystrophy skeletal muscle

Nature Communications, 2017
Facioscapulohumeral muscular dystrophy is a myopathy linked to ectopic expression of the DUX4 transcription factor. The authors show that the suppression of targets genes of the myogenesis regulator PAX7 is a signature of FSHD, and might explain ...
Christopher R. S. Banerji, Maryna Panamarova, Husam Hebaishi, Robert B. White, Frédéric Relaix, Simone Severini, Peter S. Zammit   +6 more
doaj   +1 more source

Restricted Pax3 Deletion within the Neural Tube Results in Congenital Hydrocephalus

Journal of Developmental Biology, 2016
Congenital hydrocephalus is a common birth-defect whose developmental origins are poorly understood. Pax3-null mutants show defects in myogenesis, neural tube closure, neural crest morphogenesis, and heart development that, consequently, results in ...
Hong-Ming Zhou, Simon J. Conway
doaj   +1 more source

Cytoskeleton–Membrane Uncoupling in Duchenne Muscular Dystrophy: Implications for Newborn Screening and Early Protection

Cytoskeleton, EarlyView.
ABSTRACT The cytoskeleton of striated muscle integrates force transmission, mechanotransduction, and sarcolemmal stability through coordinated networks of sarcomeres, costameres, and intermediate filaments. Together, these systems establish mechanical continuity between the contractile apparatus, the sarcolemma, and the extracellular matrix.
Houda Cohen, Nora Hosny, Brian R. Thompson, Joseph M. Metzger   +3 more
wiley   +1 more source

Satellite cell distribution in the medial rectus muscle in cadavers [PDF]

Kosin Medical Journal
Background This study aimed to elucidate the potential usefulness of the medial rectus muscle of cadavers for research on satellite cells. Methods Twenty-four medial rectus muscles were obtained from 12 cadavers.
Chang Zoo Kim, Sang Joon Lee
doaj   +1 more source

Additional file 8: Figure S8. of Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures

, 2017
DUX4 and PAX7 are expressed in distinct cell types during myogenic differentiation of human ES cells with FSHD. A, B, C, D, E and F) Images of hESC-FSHD from D40 of the differentiation protocol stained with antibodies to both PAX7 and DUX4. Arrows indicate representative DUX4 positive nuclei counted. (DOCX 6109 kb)
Premi Haynes, Kernan, Kelly, Suk-Lin Zhou, Miller, Daniel   +3 more
openaire   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Additional file 2: Figure S2. of Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures

, 2017
Human ES cells differentiate into skeletal myocytes with progressive expression of myogenic markers characteristic of early, middle, and late stages of myogenesis. Bright field images of A) HESC-Cntrl and D) FSHD at the various stages of differentiation.
Premi Haynes, Kernan, Kelly, Suk-Lin Zhou, Miller, Daniel   +3 more
openaire   +1 more source

Inhibition of Ornithine Decarboxylase 1 Mitigates Denervation‐Induced Muscle Atrophy by Suppressing Proteolysis and Preserving Muscle Stem Cell Homeostasis

Cell Proliferation, EarlyView.
Polyamine metabolism is innervation responsive and involved in denervation‐induced muscle atrophy. Inhibition of polyamine metabolism attenuates muscle atrophy by restraining proteolysis and preserving MuSCs homeostasis. Denervation‐induced activation of FAP‐derived FGF7 drives premature MuSCs activation, while DFMO suppresses this paracrine cue to ...
Mingming Zhang, Feifan Chang, Siliang Ge, Fuming Cao, Pincong Fu, Haobo Zhang, Ming Chen, Yi Li, Peifu Tang, Pengbin Yin   +9 more
wiley   +1 more source