Results 51 to 60 of about 8,131 (149)

Additional file 3: Figure S3. of Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures

, 2017
DUX4 is not expressed in PAX7 positive myocytes in hiPSC-mosaic 1 with the long D4Z4 array. A, B, and C) Images of hiPSC-mosaic 1 long myocytes from D40 of the differentiation protocol stained with antibodies to both PAX7 and DUX4 and utilized to quantify the number of DUX4 and PAX7 positive cells. (DOCX 4880 kb)
Premi Haynes, Kernan, Kelly, Suk-Lin Zhou, Miller, Daniel   +3 more
openaire   +1 more source

Dnajb5 From Antarctic Fish Reveals a Redox‐Sensitive Mechanism Coordinating Muscle Regeneration via mTORC1 and HDAC4

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Dnajb5, a member of the heat shock protein family, has not been previously reported to play a role in muscle differentiation. We identify Dnajb5 as a negative regulator of myogenesis via mammalian target of rapamycin (mTOR) and histone deacetylase 4 (HDAC4) signalling, functioning as a central controller of muscle growth and ...
Sun‐Hee Cho, Min‐Kyung Choi, Mi‐Ock Baek, Hyeon‐Hee Son, Binh Thanh Nguyen, Min‐Jung Kang, Il‐Chan Kim, Jin‐Hyoung Kim, Mee‐Sup Yoon   +8 more
wiley   +1 more source

Additional file 1: Figure S1. of Expression patterns of FSHD-causing DUX4 and myogenic transcription factors PAX3 and PAX7 are spatially distinct in differentiating human stem cell cultures

, 2017
Human iPS isogenic clones hiPSC-mosaic 2 with long and short D4Z4 array differentiate into skeletal myocytes with progressive expression of myogenic markers characteristic of early, middle, and late stages of myogenesis. Bright field images of A) hiPSC-mosaic2-long and D) hiPSC-mosaic2-short at the various stages of differentiation.
Premi Haynes, Kernan, Kelly, Suk-Lin Zhou, Miller, Daniel   +3 more
openaire   +1 more source

Downstream Pathways of Dystrophin Deficiency in Duchenne Muscular Dystrophy: Implications for Muscle Degeneration and Regeneration

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Duchenne muscular dystrophy (DMD) is the most common and severe form of muscular dystrophy, primarily affecting skeletal muscle and leading to premature death. Although the loss of dystrophin has long been recognised as the primary cause of the disease, no definitive cure is currently available. As a consequence, therapeutic efforts
Raffaele Epis, Gabriele Rovetta, Giulia Ferrari, Chiara Bonfanti, Giorgia Careccia, Graziella Messina   +5 more
wiley   +1 more source

Effect of oblique needling at Ashi-point on expression of MyoD1/Pax7 in mice with quadriceps femoris injury

针刺研究, 2021
Objective To observe the effect of oblique needling at Ashi-point on behavior, and cell morphology, myogenic differentiation antigen(MyoD1) and paired box transcription factor Pax7(Pax7) of quadriceps femoris tissue in quadriceps femoris injured mice ...
ZOU Yuan, LIU Tong, LI Jian, FENG Jing, LIU Zhi-dan, LI Qiao-qiao, CHEN Yuan-lin, HUANG Yi-ran, LI Wen-xun   +8 more
doaj  

Satellite Cells in Skeletal Muscle of the Hibernating Dormouse, a Natural Model of Quiescence and Re-Activation: Focus on the Cell Nucleus

Cells, 2020
Satellite cells (SCs) participate in skeletal muscle plasticity/regeneration. Activation of SCs implies that nuclear changes underpin a new functional status.
Manuela Malatesta, Manuela Costanzo, Barbara Cisterna, Carlo Zancanaro   +3 more
doaj   +1 more source

Transgene-free direct conversion of murine fibroblasts into functional muscle stem cells

npj Regenerative Medicine, 2023
Transcription factor-based cellular reprogramming provides an attractive approach to produce desired cell types for regenerative medicine purposes. Such cellular conversions are widely dependent on viral vectors to efficiently deliver and express defined
Xhem Qabrati, Inseon Kim, Adhideb Ghosh, Nicola Bundschuh, Falko Noé, Andrew S. Palmer, Ori Bar-Nur   +6 more
doaj   +1 more source

Early and Divergent Lipid Mediator Remodelling in Fast Versus Slow Skeletal Muscles of Female hSOD1G93A Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Skeletal muscle atrophy in amyotrophic lateral sclerosis (ALS) drives loss of muscle strength, function and quality of life in ALS patients. The endocannabinoid system (ECS) regulates muscle homeostasis via regenerative and metabolic processes, and although ECS alterations have been reported in ALS neural tissues, ECS remodelling ...
Sebastiaan Dalle, Kaat Vanderbeke, Thibaut Burg, Moniek Schouten, Wout Lauriks, Nicole Hersmus, Ludo Van Den Bosch, Katrien Koppo   +7 more
wiley   +1 more source

Dynamic transcriptional signature and cell fate analysis reveals plasticity of individual neural plate border cells

eLife, 2017
The ‘neural plate border’ of vertebrate embryos contains precursors of neural crest and placode cells, both defining vertebrate characteristics. How these lineages segregate from neural and epidermal fates has been a matter of debate.
Daniela Roellig, Johanna Tan-Cabugao, Sevan Esaian, Marianne E Bronner   +3 more
doaj   +1 more source

NEDD4-1 deficiency impairs satellite cell function during skeletal muscle regeneration

Biological Research, 2023
Background Satellite cells are tissue-specific stem cells primarily responsible for the regenerative capacity of skeletal muscle. Satellite cell function and maintenance are regulated by extrinsic and intrinsic mechanisms, including the ubiquitin ...
Felipe Cabezas, Claudio Cabello-Verrugio, Natalia González, Jeremy Salas, Manuel J. Ramírez, Eduardo de la Vega, Hugo C. Olguín   +6 more
doaj   +1 more source