Results 141 to 150 of about 5,722 (164)

Determination of Functional Domains of the Human Transcription Factor PAX8 Responsible for its Nuclear Localization and Transactivating Potential

FEBS Journal, 1997
The conserved structure of the transcription factors of the Pax gene family may reflect functional conservation. We have demonstrated that the human Pax8 transcription factor is organized in several functional domains and contains two regions responsible for its nuclear localization, in addition to an activating region at the carboxy terminus of the ...
Andrej Poleev, Olga Okladnova
exaly   +3 more sources

Immunohistochemical Detection of Pax8 and Napsin A in Canine Thyroid Tumours: Comparison with Thyroglobulin, Calcitonin and Thyroid Transcription Factor 1

Journal of Comparative Pathology, 2016
Expression of thyroid transcription factor (TTF)-1 corroborates a thyroid origin of neoplasms. Thyroglobulin and calcitonin immunohistochemistry (IHC) can distinguish between a follicular and C-cell origin of thyroid tumours, respectively. Pax8 (expressed by normal canine thyroid follicular cells) and napsin A (expressed mainly by C-cells) labelling ...
J A, Ramos-Vara, C B, Frank, D, DuSold, M A, Miller   +3 more
openaire   +2 more sources

The HNF1β transcription factor has several domains involved in nephrogenesis and partially rescues Pax8/lim1‐induced kidney malformations

European Journal of Biochemistry, 2004
The tissue‐specific transcription factors HNF1α and HNF1β are closely related homeodomain proteins conserved in vertebrate evolution. Heterozygous mutations in human HNF1β but not in HNF1α genes are associated with kidney malformations. Overexpression of HNF1β in Xenopus embryos leads to defective pronephros development, while HNF1α has no effect.
Guizhi, Wu, Silvia, Bohn, Gerhart U, Ryffel   +2 more
openaire   +2 more sources

Modification of the transcription factor Pax8 by SUMO

2006
The transcription factor Pax8 is involved in the expression of the thyroid-specific genes that are considered markers of the differentiated phenotype. The regulation of Pax8 activity is likely to play a key role in thyroid differentiation as well as in thyroid malignant transformation.
de Cristofaro T, Pappalardo A, Mascia A, Zannini S   +3 more
openaire   +2 more sources

Pregnancy hormones induce expression of the transcription factor Pax8 in a subpopulation of islet cells

2015
This work is funded by the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III (PI10/00871) and by the Foundación Pública Adanluza Progreso y Salud.
Jiménez-Moreno, Carmen M., Delgado, Irene, Cobo-Vuilleumier, Nadia, Bosco, Domenico, Rojas, Anabel, Lorenzo, Petra Isabel, Gauthier, Benoit R.   +6 more
openaire   +2 more sources

Transcriptional activation of the bcl-2 apoptosis suppressor gene by the paired box transcription factor PAX8.

Anticancer research, 1998
The bcl-2 proto-oncogene suppresses apoptosis in a variety of cell types and is essential for normal renal development. PAX8 is a member of the paired box class of transcription factors and is developmentally regulated. bcl-2 and PAX8 are both expressed in the kidney during development and throughout life, demonstrating a nearly identical pattern of ...
S M, Hewitt, S, Hamada, A, Monarres, L V, Kottical, G F, Saunders, T J, McDonnell   +5 more
openaire   +1 more source

CDH-16 is a novel target of the transcription factor Pax8

2010
Cadherins are a superfamily of calcium-binding membrane glycoproteins that mediate homotypic cell-cell interactions and are involved in morphogenetic processes such as cell compaction, epithelial differentiation and cell migration. Cadherin-16 (CDH-16) was identified as a tissue-specific cadherin found exclusively in the kidney (therefore originally ...
Tiziana de Cristofaro, Imma Fichera, Tina Di Palma, Mariastella Zannini   +3 more
openaire   +2 more sources

Possible regulation of Wilms’ tumour gene 1 (WT1) expression by the paired box genes PAX2 and PAX8 and by the haematopoietic transcription factor GATA‐1 in human acute myeloid leukaemias

British Journal of Haematology, 2003
Summary. Overexpression of the embryonic transcription factor, Wilms’ tumour protein 1 (WT1), is common in acute myeloid leukaemias (AML). Mutations of Wilms’ tumour gene 1 (WT1) in AML are rare and WT1 expression may be increased by other transcription factors. PAX2, PAX8 and GATA‐1 are known physiological regulators of WT1.
Jan M, Siehl, Eckhard, Thiel, Karin, Heufelder, Emilian, Snarski, Stefan, Schwartz, Volker, Mailänder, Ulrich, Keilholz   +6 more
openaire   +2 more sources

Diagnostic Value of Immunostaining for Thyroid Transcription Factor 1 (TTF1) and Paired Box 8 (PAX8) in Distinguishing Pulmonary Metastases of Mesonephric and Mesonephric-like Adenocarcinomas from Primary Lung Adenocarcinomas

Anticancer Research
Both mesonephric adenocarcinoma (MA) and mesonephric-like adenocarcinoma (MLA) express thyroid transcription factor 1 (TTF1). TTF1 is also considered a highly sensitive and specific diagnostic marker for primary lung adenocarcinoma (PLA). However, distinguishing PLA from pulmonary metastatic MA/MLA (PMM) based on the expression of TTF1 alone can be ...
Nayoon, Ji, Yurimi, Lee, Sang Hwa, Lee, Hyun-Soo, Kim   +3 more
openaire   +2 more sources

Effects of Pax8 and TTF-1 thyroid transcription factor gene transfer in hepatoma cells: imaging of functional protein-protein interaction and iodide uptake.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2005
The thyroid transcription factors TTF-1 and Pax8 cooperate in the transcriptional activation of thyroid-specific genes such as thyroglobulin (Tg), thyroperoxidase (TPO), and sodium/iodide symporter (NIS).Dog TTF-1 (dTTF-1) and the human Pax8 (hPax8) gene were transfected in Morris hepatoma (MH3924A) cells to investigate (a) the possible visualization ...
Annette, Altmann, Ralf B, Schulz, Gabriela, Glensch, Helmut, Eskerski, Sabine, Zitzmann, Michael, Eisenhut, Uwe, Haberkorn   +6 more
openaire   +1 more source