Results 141 to 150 of about 7,348,517 (171)

Functional analysis of Nkx2.1 and Pax9 for calcitonin gene transcription

General and Comparative Endocrinology, 2007
Nkx2.1 (TTF-1), a homeodomain-containing transcription factor essential for specific gene expression in thyroid follicular cells, exists also in the thyroidal C cells that secrete calcitonin (CT). In this report, we examined the effect of Nkx2.1 on the CT gene transcription. Luciferase reporter assay using the 2kbp promoter sequence of rat CT/CGRP gene
Shigeyasu Tanaka
exaly   +3 more sources

PAX9 (paired box gene 9) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on PAX9 (paired box gene 9), with data on DNA, on the protein encoded, and where the gene is implicated.
E Robson, J Whall, M Eccles
exaly   +2 more sources

PAX9 and MSX1 transcription factor genes in non-syndromic dental agenesis

Archives of Oral Biology, 2011
The molecular variation of paired domain box gene 9 (PAX9) was previously investigated by our research group and a high degree of evolutionary conservation in coding and non-coding regions was observed except in exon 3. PAX9 is a transcription factor important in tooth development, and we wanted to verify its role in dental agenesis in detail.
Maria Cátira Bortolini, Vanessa R Paixão-Côrtes   +1 more
exaly   +3 more sources

Pax genes and organogenesis: Pax9 meets tooth development

European Journal of Oral Sciences, 1998
Pax genes encode a family of transcription factors that play key roles during embryogenesis. They are required for the development of a variety of organs including the nervous and muscular system, skeleton, eye, ear, kidney, thymus, and pancreas. Whereas the developmental roles of many of the nine known Pax genes have been analyzed in great detail, a ...
Peters, Heiko, Neubüser, Annette, Balling, Rudi   +2 more
openaire   +4 more sources

Sequence analysis of PAX9, MSX1 and AXIN2 genes in a Chinese oligodontia family

Archives of Oral Biology, 2011
The goal of our research was to look into the clinical traits and genetic mutations in nonsyndromic oligodontia in a Chinese family and to gain insight into the role of mutations of PAX9, MSX1 and AXIN2 in oligodontia phenotypes.6 subjects from a family underwent complete oral examination, including panoramic radiographs.
Jing, Wang, Fan, Jian, Jing, Chen, Hu, Wang, Yunfeng, Lin, Zhi, Yang, Xiongfei, Pan, Wenli, Lai   +7 more
openaire   +2 more sources

Mutations in MSX1, PAX9 and MMP20 genes in Saudi Arabian patients with tooth agenesis

European Journal of Medical Genetics, 2016
Tooth agenesis in human being is the most common congenital anomaly associated with dental development. Mutations in many genes such as MSH homeobox 1 (MSX1), paired box gene 9 (PAX9), ectodysplasin A (EDA) and EDA receptor (EDAR) have been associated with familial form of this condition.
Mohammad, Shahid, Hanan A, Balto, Nouf, Al-Hammad, S, Joshi, Hesham Saleh, Khalil, Ali Mohammed, Somily, Nasr Abdul-Aziz, Sinjilawi, Sameer, Al-Ghamdi, Muhammad, Faiyaz-Ul-Haque, Varinderpal S, Dhillon   +9 more
openaire   +2 more sources

Novel mutation in the paired box sequence of PAX9 gene in a sporadic form of oligodontia

European Journal of Oral Sciences, 2003
Tooth development is regulated through a series of reciprocal interactions between the dental epithelium and mesenchyme and requires protein products of a number of genes. It has been reported that selective tooth agenesis is associated with mutations in human MSX and PAX9 genes. Mutational analysis of the two genes was performed in 25 individuals with
Adrianna, Mostowska, Agnieszka, Kobielak, Barbara, Biedziak, Wieslaw H, Trzeciak   +3 more
openaire   +2 more sources

Identification of a novel mutation in thePAX9gene in a family affected by oligodontia and other dental anomalies

European Journal of Oral Sciences, 2007
The objective of the present work was to study the phenotype and the genotype of three generations of a family affected by oligodontia and other dental anomalies. These family members also presented systemic conditions such as hypercholesterolemia, hypothyroidism, diabetes mellitus, scoliosis, and congenital cardiovascular anomalies.
Victòria, Tallón-Walton, Maria Cristina, Manzanares-Céspedes, Sirpa, Arte, Patricia, Carvalho-Lobato, Ivan, Valdivia-Gandur, Antonio, Garcia-Susperregui, Francesc, Ventura, Pekka, Nieminen   +7 more
openaire   +2 more sources

[Novel mutations of PAX9 gene in Chinese patients with oligodontia].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology, 2009
To investigate the mutational characteristics of PAX9 gene in Chinese patients with congenital oligodontia and thus to provide a molecular basis for studying the pathogenesis of oligodontia.Thirteen individuals with oligodontia and 9 healthy individuals, from 4 unrelated autosomal dominant families, and 16 sporadic patients with hypodontia in China, as
Ji-lin, Zhao, Yang-xi, Chen, Lang, Bao, Qing-jie, Xia, Tuo-jiang, Wu, Li, Zhou   +5 more
openaire   +1 more source

Single Cell Spatial Transcriptomics of the Murine Embryonic Palate Links Pax9 to Patterning and Organization of Extracellular Matrix Components

Research Square
Despite advances in understanding the morphological disruptions that lead to defects in palate formation, the precise perturbations within the signaling microenvironment of palatal clefts remain poorly understood.
J. O. Piña, R. Raju, Evan Stipano, A. Myo, Ziyi Wang, M. Ono, Parna Chattaraj, M. Furukawa, Rena N. D’Souza   +8 more
semanticscholar   +1 more source