Contrasting evolutionary dynamics of the developmental regulator PAX9, among bats, with evidence for a novel post-transcriptional regulatory mechanism. [PDF]
PLoS ONE, 2013 Morphological evolution can be the result of natural selection favoring modification of developmental signaling pathways. However, little is known about the genetic basis of such phenotypic diversity.
Caleb D Phillips +4 more
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Genes Linked with Orthodontic Issues and the Knowledge Gaps in This Association
Philippine Journal of Obstetrics and Gynecology, 2023 Orthodontics is the study of malpositioned teeth and jaws. Some commonly found orthodontic issues are malocclusions, mandibular prognathism, retrognathism, and facial asymmetry. These issues are associated with several genetic factors.
Abdulaziz Mohammed Alshahrani
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Natural selection and molecular evolution in primate PAX9 gene, a major determinant of tooth development. [PDF]
Proceedings of the National Academy of Sciences, 2006 Large differences in relation to dental size, number, and morphology among and within modern human populations and between modern humans and other primate species have been observed. Molecular studies have demonstrated that tooth development is under strict genetic control, but, the genetic basis of primate tooth variation remains ...
T. V. Pereira +12 more
semanticscholar +3 more sources
Pax9 and Gbx2 Interact in the Pharyngeal Endoderm to Control Cardiovascular Development
Journal of Cardiovascular Development and Disease, 2020 The correct formation of the aortic arch arteries depends on a coordinated and regulated gene expression profile within the tissues of the pharyngeal arches.
Catherine A. Stothard +7 more
doaj +1 more source
Molecular Evolution of the Primate Developmental Genes MSX1 and PAX9 [PDF]
Molecular Biology and Evolution, 2005 In primates, the craniofacial skeleton and the dentition are marked by high levels of interspecific variation. Despite this, there are few comparative species studies conducted at the molecular level to investigate this functional diversity. We have determined nucleotide sequences of MSX1 and PAX9, two developmental genes, in a sample of 27 diverse ...
George H, Perry +2 more
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Genetic variation among major human geographic groups supports a peculiar evolutionary trend in PAX9. [PDF]
PLoS ONE, 2011 A total of 172 persons from nine South Amerindian, three African and one Eskimo populations were studied in relation to the Paired box gene 9 (PAX9) exon 3 (138 base pairs) as well as its 5'and 3'flanking intronic segments (232 bp and 220 bp ...
Vanessa R Paixão-Côrtes +9 more
doaj +1 more source
A novel mutation in the WNT6 gene of congenital tooth agenesis
口腔疾病防治, 2023 Objective This article explores the relationship between congenital tooth agenesis and related gene mutations, providing a reference for early diagnosis of the disease.
DAI Zhuo +4 more
doaj +1 more source
Transcriptional analysis of the human PAX9 promoter
Journal of Applied Oral Science, 2010 OBJECTIVES: PAX9 belongs to the Pax family of transcriptional factor genes. This gene is expressed in embryonic tissues such as somites, pharyngeal pouch endoderm, distal limb buds and neural crest-derived mesenchyme.
Carolina Vieira de Almeida +4 more
doaj +1 more source
Functional Screenings Identify Regulatory Variants Associated with Breast Cancer Susceptibility
Current Issues in Molecular Biology, 2021 Genome-wide association studies (GWAS) have identified more than 2000 single nucleotide polymorphisms (SNPs) associated with breast cancer susceptibility, most of which are located in the non-coding region.
Naixia Ren +5 more
doaj +1 more source
Role of polymorphisms of MSX1 and PAX9 genes in palatal impaction of maxillary canines [PDF]
Journal of Orthodontics, 2019 Objective: Maxillary canines are the second-most commonly impacted teeth. About two-thirds of the impacted maxillary canines are palatally impacted. Studies in the past have shown that 40% of cases with palatal impaction of maxillary canines presented with agenesis of third molars.
M S Anjana, Devi, Sridevi, Padmanabhan
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