Results 91 to 100 of about 455 (133)

A Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of An Orally Administered Drug Product: From IVIVC to IVIVP

, 2019
The application of in silico modeling to predict the in vivo outcome of an oral drug product is gaining a lot of interest. Fully relying on these models as a surrogate tool requires continuous optimization and validation. To do so, intraluminal and systemic data are desirable to judge the predicted outcomes.
openaire   +2 more sources

A review of OSP suite PBBM capabilities: looking ahead

A review of OSP suite PBBM capabilities: looking ahead
Stephan Schaller, Mariana Guimaraes, Jeremy Perrier, Marco Siccardi   +3 more
openaire   +1 more source

Mechanism-Based Pharmacokinetic and Pharmacodynamic Modeling. [PDF]

Pharmaceutics
Świerczek A.
europepmc   +1 more source

Narrow Therapeutic Index Drugs: Regulatory Frameworks, Bioequivalence, and Model-Informed Precision Dosing. [PDF]

Pharmaceutics
Liu M, Wang Z, Chen Y, Jia Y, Xu L, Xu H, Li J, Zhao L.   +7 more
europepmc   +1 more source

Impact of gastric mixing and water intake on postprandial pharmacokinetics of orally disintegrating tablets: A PBBM-based study

European Journal of Pharmaceutics and Biopharmaceutics
Yoshinori Takahashi, Kazuki Matsui, Naoya Matsumura, Atsushi Kambayashi   +3 more
openaire   +1 more source

Evaluation of USP 3 Apparatus to Develop Biopredictive Fasted and Fed Dissolution Methods for Extended-Release Desvenlafaxine Succinate Tablets. [PDF]

ACS Omega
Carapeto GV, Nunes BC, Duque MD, Issa MG, Ferraz HG.   +4 more
europepmc   +1 more source

Physiologically Based Pharmacokinetic Modeling of Efavirenz Nanoparticles: from Animal Model to Human Extrapolation. [PDF]

ACS Omega
da Silva TM, Sarcinelli MA, Cunha Chaves MH, Dias AA, Patricio BFC, Prado LD, Tasso L, Duque MD, Rocha HVA.   +8 more
europepmc   +1 more source

Development of in vitro-in vivo correlation for establishing patient-centric quality standards of dissolution for lamotrigine extended-release tablets. [PDF]

Eur J Pharm Biopharm
Zidan A, Siddique AB, Shaklah M, Anand O, O'Connor T, Ashraf M.   +5 more
europepmc   +1 more source

Efficient production of gene-edited onion (Allium cepa) plants using biolistic delivery of cas9 RNPs and transient expression constructs. [PDF]

Plant Cell Rep
De La Mora CL, Havey MJ, Krysan PJ.
europepmc   +1 more source

Advances in Physiologically Based Pharmacokinetic (PBPK) Modeling and its Regulatory Utility to Support Oral Drug Product Development and Harmonization. [PDF]

Pharm Res
Cheng YH, Thomas S, Tsang YC, Almeida S, Ashraf M, Fotaki N, Heimbach T, Patel N, Shah H, Jiang X, Kim MJ, Moody R, Rostami-Hodjegan A, Singh R, Zhao L, Babiskin A, Wu F.   +16 more
europepmc   +1 more source