Optimization of Dissolution Compartments in a Biorelevant Dissolution Apparatus Golem v2, Supported by Multivariate Analysis [PDF]
Molecules, 2017 Biorelevant dissolution instruments represent an important tool for pharmaceutical research and development. These instruments are designed to simulate the dissolution of drug formulations in conditions most closely mimicking the gastrointestinal tract ...
Jakub Vysloužil +2 more
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Pharmaceutics, 2022 Praziquantel is a poorly water-soluble drug used to treat parasitic infections. Previous studies have suggested that its rate and extent of dissolution in milk and biorelevant media are slow and limited compared to dissolution in the pharmacopoeial ...
Ben J. Boyd +2 more
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Exploration of Neusilin® US2 as an Acceptable Filler in HPMC Matrix Systems—Comparison of Pharmacopoeial and Dynamic Biorelevant Dissolution Study [PDF]
Pharmaceutics, 2022 Modern pharmaceutical technology still seeks new excipients and investigates the further use in already known ones. An example is magnesium aluminometasilicate Neusilin® US2 (NEU), a commonly used inert filler with unique properties that are usable in ...
Tomáš Bílik +8 more
doaj +2 more sources
Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media [PDF]
Pharmaceutics, 2020 The intrinsic dissolution rate (IDR) of active pharmaceutical ingredients (API) is a key property that aids in early drug development, especially selecting formulation strategies to improve dissolution and thereby drug absorption in the intestine.
Alexandra Teleki +2 more
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Formulation-dependent dissolution and bioaccessibility of curcuminoids and (S)-ar-turmerone from eight commercial turmeric extract- and curcumin-containing dietary supplements [PDF]
Pharmaceutical BiologyContext Curcumin-containing dietary supplements are widely marketed with claims of enhanced bioavailability, despite well-recognized limitations related to poor aqueous solubility, chemical instability, and extensive first-pass metabolism.
Bill J. Gurley +7 more
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A Combined Experimental and Predictive Modeling Study of Diltiazem Release From Natural Polymer Microcapsules in Different Media. [PDF]
CPT Pharmacometrics Syst PharmacolA mechanistic sublingual absorption model was developed by integrating in vitro release kinetics of diltiazem‐loaded microcapsules with a SimBiology‐based two‐compartment model, enabling simulation of in vivo performance across physiologically relevant pH variability scenarios.
Üstün Z, Kara Ü.
europepmc +2 more sources
Development of a biorelevant dissolution method for inhalation products: Proof of concept using drugs with diverse solubilities [PDF]
ADMET and DMPKBackground and purpose: Due to their unique application and action, inhalation products require specific quality tests, such as Uniformity of Delivered Dose and Aerodynamic Assessment of Fine Particles.
Amar Elezović +4 more
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Best Practices in Physiologically Based Pharmacokinetic (PBPK) Modeling. [PDF]
CPT Pharmacometrics Syst PharmacolABSTRACT Physiologically based pharmacokinetic (PBPK) modeling is a mechanistic cornerstone of model‐informed drug development (MIDD), providing evidence for regulatory decisions. PBPK models integrate physiological and pharmacological data and have been applied across a plethora of contexts of use, including assessing drug–drug interactions (DDIs ...
Chenel M +6 more
europepmc +2 more sources
Comparative evaluation of USP II, USP IV, TIM-2, and the dynamic colon model as surrogates for human colonic drug dissolution [PDF]
RSC PharmaceuticsThis study compares conventional dissolution apparatuses (USP II and IV) with advanced biorelevant models (TIM-2 and the Dynamic Colon Model, DCM) for assessing colonic drug dissolution. Theophylline dissolution from modified-release Uniphyllin Continus®
Khushi Khandelwal +3 more
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Pharmaceutics, 2023 Particle size reduction is a commonly used process to improve the solubility and the dissolution of drug formulations. The solubility of a drug in the gastrointestinal tract is a crucial parameter, because it can greatly influence the bioavailability ...
Péter Horváth +2 more
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