Optimization of Dissolution Compartments in a Biorelevant Dissolution Apparatus Golem v2, Supported by Multivariate Analysis [PDF]
Molecules, 2017 Biorelevant dissolution instruments represent an important tool for pharmaceutical research and development. These instruments are designed to simulate the dissolution of drug formulations in conditions most closely mimicking the gastrointestinal tract ...
Sylvie Pavloková +2 more
exaly +7 more sources
Revisiting the Dissolution of Praziquantel in Biorelevant Media and the Impact of Digestion of Milk on Drug Dissolution [PDF]
Pharmaceutics, 2022 Praziquantel is a poorly water-soluble drug used to treat parasitic infections. Previous studies have suggested that its rate and extent of dissolution in milk and biorelevant media are slow and limited compared to dissolution in the pharmacopoeial ...
Thomas Eason +2 more
exaly +6 more sources
Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media [PDF]
Pharmaceutics, 2020 The intrinsic dissolution rate (IDR) of active pharmaceutical ingredients (API) is a key property that aids in early drug development, especially selecting formulation strategies to improve dissolution and thereby drug absorption in the intestine.
Alexandra Teleki +2 more
doaj +7 more sources
Exploration of Neusilin® US2 as an Acceptable Filler in HPMC Matrix Systems—Comparison of Pharmacopoeial and Dynamic Biorelevant Dissolution Study [PDF]
Pharmaceutics, 2022 Modern pharmaceutical technology still seeks new excipients and investigates the further use in already known ones. An example is magnesium aluminometasilicate Neusilin® US2 (NEU), a commonly used inert filler with unique properties that are usable in ...
Tomáš Bílik +8 more
doaj +2 more sources
Biorelevant dissolution of candesartan cilexetil [PDF]
ADMET and DMPK, 2017 The choice of an appropriate medium for dissolution tests is an essential step during a dosage form development. The adequate design of dissolution testing enables forecasting in vivo behavior of drug formulation.
Lucie Gruberová, Bohumil Kratochvil
doaj +3 more sources
Development and Validation of Discriminating and Biorelevant Dissolution Test for Lornoxicam Tablets. [PDF]
Indian J Pharm Sci, 2015 The establishment of biorelevant and discriminating dissolution procedure for drug products with limited water solubility is a useful technique for qualitative forecasting of the in vivo behavior of formulations. It also characterizes the drug product performance in pharmaceutical development.
Anumolu PD +4 more
europepmc +4 more sources
Design and Evaluation of Two-Step Biorelevant Dissolution Methods for Docetaxel Oral Formulations. [PDF]
AAPS PharmSciTech, 2022 Dissolution is a pivotal tool for oral formulations. Dissolution could be used to either reduce the risk of product failure through quality control or predict and understand in vivo performance of drug formulations. The latter is always challenging because multiple factors such as selection of media, gastrointestinal components, physiological factors ...
Shah B, Dong X.
europepmc +3 more sources
Formulation-dependent dissolution and bioaccessibility of curcuminoids and (S)-ar-turmerone from eight commercial turmeric extract- and curcumin-containing dietary supplements [PDF]
Pharmaceutical BiologyContext Curcumin-containing dietary supplements are widely marketed with claims of enhanced bioavailability, despite well-recognized limitations related to poor aqueous solubility, chemical instability, and extensive first-pass metabolism.
Bill J. Gurley +7 more
doaj +2 more sources
Development of a biorelevant dissolution method for inhalation products: Proof of concept using drugs with diverse solubilities [PDF]
ADMET and DMPKBackground and purpose: Due to their unique application and action, inhalation products require specific quality tests, such as Uniformity of Delivered Dose and Aerodynamic Assessment of Fine Particles.
Amar Elezović +4 more
doaj +2 more sources
The use of biorelevant dissolution media to forecast the in vivo performance of a drug. [PDF]
AAPS J, 2010 Simulation of gastrointestinal conditions is essential to adequately predict the in vivo behavior of drug formulations. To reduce the size and number of human studies required to identify a drug product with appropriate performance in both the fed and fasted states, it is advantageous to be able to pre-screen formulations in vitro.
Klein S.
europepmc +4 more sources