Results 41 to 50 of about 224,448 (162)

Stability of Biorelevant Media Under Various Storage Conditions

, 2022
S.6-18The physical and chemical stability of various biorelevant media (FaSSGF, FaSSIF V1, FaSSIF V2, FaSSIF V3, and FeSSIF) were investigated over periods after preparation of up to 120 h at room temperature (RT) (22 degrees C) and 37 degrees C.
Ashtikar, M., Nagasekar, K., Seybert, A., Dressman, J., Klumpp, L., McCullough, O.   +5 more
core   +1 more source

Investigating Tacrolimus Disposition in Paediatric Patients with a Physiologically Based Pharmacokinetic Model Incorporating CYP3A4 Ontogeny, Mechanistic Absorption and Red Blood Cell Binding

Pharmaceutics, 2023
Tacrolimus is a crucial immunosuppressant for organ transplant patients, requiring therapeutic drug monitoring due to its variable exposure after oral intake.
Matthias Van der Veken, Joachim Brouwers, Agustos Cetin Ozbey, Kenichi Umehara, Cordula Stillhart, Noël Knops, Patrick Augustijns, Neil John Parrott   +7 more
doaj   +1 more source

Tensile Stimulation in Biorelevant Culture Conditions Enhances MSC and TPSC Tenogenesis on Aligned Electrospun Scaffolds

Advanced NanoBiomed Research, Volume 6, Issue 8, August 2026.
Biomimetic electrospun scaffold incorporating GDF‐7‐loaded mesoporous silica nanoparticles, combined with mechanical stimulation and physiological oxygen tension, guides tenogenic differentiation of mesenchymal stromal cell and tendon progenitor stem cell. This integrated approach enhances cell proliferation, matrix deposition, and tendon‐specific gene
Vera Citro, Aldo R. Boccaccini, Nicholas R. Forsyth, Tina P. Dale   +3 more
wiley   +1 more source

The development and validation of analytical methods for the quantitative determination of dabigatran etexilate by HPLC-DAD and UV spectrophotometry during a comparative dissolution kinetics test of dabigatran capsules in the biorelevant FaSSGF medium

Разработка и регистрация лекарственных средств
Introduction. Venous thromboembolism and atrial fibrillation are significant causes of vascular mortality. Anticoagulant therapy significantly reduces the risk of ischemic stroke, and dabigatran etexilate, a direct thrombin inhibitor, has become firmly ...
D. M. Devyatkina, P. S. Mashchenko, A. D. Vnutskikh, I. O. Devyatkin, N. A. Prozorova, A. V. Foteeva   +5 more
doaj   +1 more source

Development of a Biphasic-Release Multiple-Unit Pellet System with Diclofenac Sodium Using Novel Calcium Phosphate-Based Starter Pellets

Pharmaceutics, 2021
Novel calcium phosphate-based starter pellets were used to develop a biphasic-release multiple-unit pellet system (MUPS) with diclofenac sodium as a model drug in the form of hard gelatin capsules.
Daniel Zakowiecki, Maja Frankiewicz, Tobias Hess, Krzysztof Cal, Maciej Gajda, Justyna Dabrowska, Bartlomiej Kubiak, Jadwiga Paszkowska, Marcela Wiater, Dagmara Hoc, Grzegorz Garbacz, Dorota Haznar-Garbacz   +11 more
doaj   +1 more source

A Water‐Soluble Fluorescent 2,5‐bis(arylethynyl)rhodacyclopentadiene for Live‐Cell Imaging and Sensing of DNA, RNA, and Protein (BSA)

ChemPhotoChem, Volume 10, Issue 8, August 2026.
A water‐soluble and ‐stable 2,5‐bis(arylethynyl)rhodacyclopentadiene fluoresces, with no observable phosphorescence. However, competitive ISC to T1 leads to potent 1O2 sensitization. It binds strongly to DNA, RNA, and protein (BSA); efficiently enters living human cells accumulating preferentially in mitochondrial membranes; and is nontoxic even at ...
Shishir Ghosh, Florian Kerner, Tim Görlich, Alexandra Friedrich, Sabine Lorenzen, Jörn Nitsch, Evripidis Michail, Christoph Lambert, Anissa Amar, Abdou Boucekkine, Jean‐François Halet, Marta Jurković, Ksenija Božinović, Ivo Piantanida, Todd B. Marder   +14 more
wiley   +1 more source

Moving and Union Dissolution [PDF]

, 2008
This paper examines the effect of migration and residential mobility on union dissolution among married and cohabiting couples. Moving is a stressful life event, and a large, multidisciplinary litera-ture has shown that family migration often benefits ...
Cooke, T., Boyle, P.J., Kulu, Hill, Mulder, Clara H, Boyle, Paul, Cooke, Thomas, Gayle, V., Mulder, Clara H., Kulu, H., Gayle, Vernon, Mulder, C.H., Boyle, Paul J.   +11 more
core   +2 more sources

Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution

Acta Pharmaceutica, 2014
Ciprofloxacin bioavailability may be reduced when ciprofloxacin is co-administered with metallic ion containing preparations. In our previous study, physicochemical interaction between ciprofloxacin and ferrous sulphate was successfully simulated in ...
Stojković Aleksandra, Tajber Lidia, Paluch Krzysztof J., Djurić Zorica, Parojčić Jelena, Corrigan Owen I.   +5 more
doaj   +1 more source

Sex‐Related Differences in Physiologically‐Based Biopharmaceutics Modeling

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 8, August 2026.
Sex‐related differences in gastrointestinal tract physiology and their incorporation into three widely used PBPK platforms (PK‐Sim, GastroPlus, Simcyp) were evaluated. A ketoprofen PBPK model was developed and verified in males, then extrapolated to females using default and sex‐specific refined parameters, demonstrating that user‐defined adjustments ...
Marianela Chavarría‐Rojas, Mubtasim Murshed, Marianela Lorier, Nikoletta Fotaki, Manuel Ibarra   +4 more
wiley   +1 more source

Poly(O‐Propargyl‐N‐Amino Carbamate), a Reactive Polymer to Underpin Biomedical Applications of Poly(acetylene)s

Macromolecular Rapid Communications, Volume 47, Issue 14, 20 July 2026.
We report here a new methodology to prepare functional poly(acetylene)s under aqueous conditions. This methodology is underpinned by poly(O‐propargyl‐N‐amino carbamate) (P1), a reactive poly(acetylene) carrying acyl hydrazines. Thus, P1 reacts with aldehydes to give functional poly(acetylene)s, including cationic, hydrophobic, and sugar‐loaded poly ...
Tom Leigh, Greta Bellio, Daniel Crisan, Amit Deb, Alba Ramil‐Bouzas, Andrey Romanyuk, Ivan Torreiro‐Leon, Ana Rey‐Rico, Paco Fernandez‐Trillo   +8 more
wiley   +1 more source