Results 41 to 50 of about 1,723 (196)

Biopharmaceutical relevance of dissolution profile comparison: Proposal of a combined approach [PDF]

, 2014
The aims of the present study were to evaluate the performance of the main methods proposed for the comparison of percentage dissolved versus time curves and to recommend a more biorelevant combined approach for the comparison of dissolution profiles of ...
Ruiz, María Esperanza, Volonté, María Guillermina   +1 more
core   +2 more sources

Can biorelevant media be simplified by using SLS and tween 80 to replace bile compounds?

, 2013
In the scientific literature, the use of a surfactant is recommended for both designing quality control tests for water insoluble or sparingly water soluble drugs and for predicting the bioavailability of drugs from various types of formulations.
Taupitz, Thomas, Klein, Sandra
core   +1 more source

Biorelevant Dissolution: Methodology and Application in Drug Development

Dissolution Technologies, 2009
INTRODUCTION Dissolution testing can play an important role in several areas for drug products as a quality control tool to monitor batch-to-batch consistency of drug release from a dosage form and as an in vitro surrogate for in vivo performance that can guide formulation development and ascertain the need for bioequivalence tests.
Qingxi Wang, Nikoletta Fotaki, Yun Mao
openaire   +1 more source

PBPK modeling coupled with biorelevant dissolution to forecast the oral performance of amorphous solid dispersion formulations

, 2022
S.83-90The aim of this research was to develop an in silico modeling and simulation approach to predict the oral performance of a poorly soluble drug candidate, T2CP, formulated as an amorphous solid dispersion and an amorphous powder.
Fujiwara, M., Kambayashi, A., Kiyota, T., Dressman, J.   +3 more
core   +1 more source

Investigating Tacrolimus Disposition in Paediatric Patients with a Physiologically Based Pharmacokinetic Model Incorporating CYP3A4 Ontogeny, Mechanistic Absorption and Red Blood Cell Binding

Pharmaceutics, 2023
Tacrolimus is a crucial immunosuppressant for organ transplant patients, requiring therapeutic drug monitoring due to its variable exposure after oral intake.
Matthias Van der Veken, Joachim Brouwers, Agustos Cetin Ozbey, Kenichi Umehara, Cordula Stillhart, Noël Knops, Patrick Augustijns, Neil John Parrott   +7 more
doaj   +1 more source

Poly(O‐Propargyl‐N‐Amino Carbamate), a Reactive Polymer to Underpin Biomedical Applications of Poly(acetylene)s

Macromolecular Rapid Communications, EarlyView.
We report here a new methodology to prepare functional poly(acetylene)s under aqueous conditions. This methodology is underpinned by poly(O‐propargyl‐N‐amino carbamate) (P1), a reactive poly(acetylene) carrying acyl hydrazines. Thus, P1 reacts with aldehydes to give functional poly(acetylene)s, including cationic, hydrophobic, and sugar‐loaded poly ...
Tom Leigh, Greta Bellio, Daniel Crisan, Amit Deb, Alba Ramil‐Bouzas, Andrey Romanyuk, Ivan Torreiro‐Leon, Ana Rey‐Rico, Paco Fernandez‐Trillo   +8 more
wiley   +1 more source

Development of a Biphasic-Release Multiple-Unit Pellet System with Diclofenac Sodium Using Novel Calcium Phosphate-Based Starter Pellets

Pharmaceutics, 2021
Novel calcium phosphate-based starter pellets were used to develop a biphasic-release multiple-unit pellet system (MUPS) with diclofenac sodium as a model drug in the form of hard gelatin capsules.
Daniel Zakowiecki, Maja Frankiewicz, Tobias Hess, Krzysztof Cal, Maciej Gajda, Justyna Dabrowska, Bartlomiej Kubiak, Jadwiga Paszkowska, Marcela Wiater, Dagmara Hoc, Grzegorz Garbacz, Dorota Haznar-Garbacz   +11 more
doaj   +1 more source

Bidirectional Photoswitching of a Tailored Azobenzene with Red and Far‐Red Light Involving Triplet Sensitization in an Aqueous System

Advanced Science, Volume 13, Issue 36, 29 June 2026.
The action spectrum of a tailored azobenzene is shifted toward bio‐optical window through the chemical modification of its singlet and triplet energy levels. Consequently, the bidirectional photo‐switching of azobenzene in physiological conditions is achieved when excited by red and far‐red light, which offers greater tissue penetration.
Mila Miroshnichenko, Helen Hölzel, Edvinas Orentas, Karolis Kazlauskas, Pedro Ferreira, Fabienne Dumoulin, Carles Alcaide, Miquel Solà, Roger Bresolí‐Obach, Santi Nonell, Pankaj Bharmoria, Kasper Moth‐Poulsen   +11 more
wiley   +1 more source

Potential of Covalent Organic Framework in Pharmacy and Biomedicine: Influence of Structure on Properties and Applications

ChemMedChem, Volume 21, Issue 9, 14 May 2026.
From modular COF design to biomedical translation, this Review maps how linkage chemistry, topology, pore environment, and particle engineering govern bioperformance, therapeutic and diagnostic function, safety, and clinical readiness. Covalent organic frameworks (COFs) are a versatile class of crystalline porous materials with growing potential in ...
Julia Kolodziejczyk, Marta E. Plonska‐Brzezinska   +1 more
wiley   +1 more source

Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution

Acta Pharmaceutica, 2014
Ciprofloxacin bioavailability may be reduced when ciprofloxacin is co-administered with metallic ion containing preparations. In our previous study, physicochemical interaction between ciprofloxacin and ferrous sulphate was successfully simulated in ...
Stojković Aleksandra, Tajber Lidia, Paluch Krzysztof J., Djurić Zorica, Parojčić Jelena, Corrigan Owen I.   +5 more
doaj   +1 more source