Results 31 to 40 of about 1,723 (196)

Modelling and Simulation of the Drug Release from a Solid Dosage Form in the Human Ascending Colon: The Influence of Different Motility Patterns and Fluid Viscosities

Pharmaceutics, 2021
For colonic drug delivery, the ascending part of the colon is the most favourable site as it offers the most suitable environmental conditions for drug dissolution.
Michael Schütt, Konstantinos Stamatopoulos, Hannah K. Batchelor, Mark J. H. Simmons, Alessio Alexiadis   +4 more
doaj   +1 more source

Dissolution Behavior of Flufenamic Acid in Heated Mixtures with Nanocellulose

Molecules, 2020
Flufenamic acid (FFA) is a problem drug that has up to eight different polymorphs and shows poor solubility. Variability in bioavailability has been reported in the past resulting in limited use of FFA in the oral solid dosage form.
Athanasios Mantas, Albert Mihranyan
doaj   +1 more source

Biorelevant Dissolution of Dipyridamole and Piroxicam Using an Automated UV/Vis Spectrophotometric and Potentiometric Dissolution Testing Platform

, 2023
The objective of this study was to investigate the implications of changing dissolution parameters, including pH ramp time, absence and presence of simulated intestinal fluid (SIF), and the addition of a partitioning phase, using an automated dissolution-
Anette Müllertz, Box, Karl, Berthelsen, Ragna, Østergaard, Jesper, Karl Box, Larsen, Susan Weng, Susan Weng Larsen, Jesper Østergaard, Müllertz, Anette, Ragna Berthelsen   +9 more
core   +1 more source

A Rational Approach to Predicting Immediate Release Formulation Behavior in Multiple Gastric Motility Patterns: A Combination of a Biorelevant Apparatus, Design of Experiments, and Machine Learning

Pharmaceutics, 2023
Gastric mechanical stress often impacts drug dissolution from solid oral dosage forms, but in vitro experiments cannot recreate the substantial variability of gastric motility in a reasonable time.
Marcela Staniszewska, Michał Romański, Sebastian Polak, Grzegorz Garbacz, Justyna Dobosz, Daria Myslitska, Svitlana Romanova, Jadwiga Paszkowska, Dorota Danielak   +8 more
doaj   +1 more source

Biorelevant dissolution testing of St John's wort products

Journal of Pharmacy and Pharmacology, 2002
Abstract In contrast to chemically defined drugs, most herbal medicinal products (HMPs) are poorly characterized in terms of their pharmaceutical properties. In many cases it is assumed that the plant extract as a whole is the active moiety, since it is often difficult to identify the individual components responsible for the ...
Kerstin, Westerhoff, Astrid, Kaunzinger, Mario, Wurglics, Jennifer, Dressman, Manfred, Schubert-Zsilavecz   +4 more
openaire   +2 more sources

Dissolution rate of ciprofloxacin and its cocrystal with resorcinol

ADMET and DMPK, 2018
The synthesis of cocrystals is presented as an alternative to improve the properties of active pharmaceutical ingredients, especially those related to solubility and dissolution rate.
Clara Ràfols, Hanan Fael, Elisabet Fuguet, Breeze Outhwaite, Samuel Lee, Rebeca Ruiz   +5 more
doaj   +1 more source

Advanced In Vivo Prediction by Introducing Biphasic Dissolution Data into PBPK Models

Pharmaceutics, 2023
Coupling biorelevant in vitro dissolution with in silico physiological-based pharmacokinetic (PBPK) tools represents a promising method to describe and predict the in vivo performance of drug candidates in formulation development including non-passive ...
Alexander Denninger, Tim Becker, Ulrich Westedt, Karl G. Wagner   +3 more
doaj   +1 more source

Stability of Biorelevant Media Under Various Storage Conditions

, 2022
S.6-18The physical and chemical stability of various biorelevant media (FaSSGF, FaSSIF V1, FaSSIF V2, FaSSIF V3, and FeSSIF) were investigated over periods after preparation of up to 120 h at room temperature (RT) (22 degrees C) and 37 degrees C.
Ashtikar, M., Nagasekar, K., Seybert, A., Dressman, J., Klumpp, L., McCullough, O.   +5 more
core   +1 more source

Dissolution and precipitation behavior of ternary solid dispersions of ezetimibe in biorelevant media [PDF]

Drug Development and Industrial Pharmacy, 2016
The effects of different formulations and processes on inducing and maintaining the supersaturation of ternary solid dispersions of ezetimibe (EZ) in two biorelevant media fasted-state simulated intestinal fluid (FaSSIF) and fasted-state simulated gastric fluid (FaSSGF) at different temperatures (25 °C and 37 °C) were investigated in this work. Ternary
Amani, Alhayali, Staffan, Tavellin, Sitaram, Velaga   +2 more
openaire   +2 more sources

Dissolution of theophylline from extended-release tablets under cyclic retrograde peristaltic contractions in the Dynamic Colon Model

British Journal of Pharmacy, 2022
The dynamic colon model isa biorelevant in vitro model of the human proximal colon. In vivo, the large intestine mixes its contents using peristaltic waves that propagate both forwards(antegrade) and backwards (retrograde).
Connor O'Farrell, Konstantinos Stamatopoulos , Mark J. H. Simmons, Hannah Batchelor   +3 more
doaj   +1 more source