Results 31 to 40 of about 224,448 (162)
Pharmaceutics, 2023 Gastric mechanical stress often impacts drug dissolution from solid oral dosage forms, but in vitro experiments cannot recreate the substantial variability of gastric motility in a reasonable time.
Marcela Staniszewska +8 more
doaj +1 more source
Dissolution rate of ciprofloxacin and its cocrystal with resorcinol
ADMET and DMPK, 2018 The synthesis of cocrystals is presented as an alternative to improve the properties of active pharmaceutical ingredients, especially those related to solubility and dissolution rate.
Clara Ràfols +5 more
doaj +1 more source
Advanced In Vivo Prediction by Introducing Biphasic Dissolution Data into PBPK Models
Pharmaceutics, 2023 Coupling biorelevant in vitro dissolution with in silico physiological-based pharmacokinetic (PBPK) tools represents a promising method to describe and predict the in vivo performance of drug candidates in formulation development including non-passive ...
Alexander Denninger +3 more
doaj +1 more source
Development and assessment of a USP Apparatus 3 dissolution test method for sustained-release Nevirapine matrix tablets [PDF]
, 2016 Dissolution testing is a quality control tool used to assess batch-to-batch performance of dosage forms, thereby providing continued assurance of product quality.
Mwila, Chiluba +2 more
core +1 more source
Biorelevant test for supersaturable formulation
Asian Journal of Pharmaceutical Sciences, 2017 Supersaturable formulation can generate supersaturation after dissolution, providing kinetic advantage in vivo. However, the supersaturation may precipitate before being absorbed, which makes it difficult to ensure and predict its in vivo performance ...
Enxian Lu, Shoufeng Li, Zhongqin Wang
doaj +1 more source
British Journal of Pharmacy, 2022 The dynamic colon model isa biorelevant in vitro model of the human proximal colon. In vivo, the large intestine mixes its contents using peristaltic waves that propagate both forwards(antegrade) and backwards (retrograde).
Connor O'Farrell +3 more
doaj +1 more source
, 2023 The objective of this study was to investigate the implications of changing dissolution parameters, including pH ramp time, absence and presence of simulated intestinal fluid (SIF), and the addition of a partitioning phase, using an automated dissolution-
Anette Müllertz +9 more
core +1 more source
Intrinsic dissolution simulation of highly and poorly soluble drugs for BCS solubility classification [PDF]
, 2017 Intrinsic dissolution testing allows characterizing drug substances through its dissolution rate when exposed to a specified surface area in a specific dissolution media, This can be used to determine if a drug substance is highly or poorly soluble.
Raimar Löbenberg +13 more
core +1 more source
Macromolecular Bioscience, Volume 26, Issue 9, September 2026.Personalized dosage forms engineered via hot‐melt extrusion and FDM 3D‐printing enable the evaluation of novel anti‐Alzheimer's compounds. The study integrates dissolution testing, thermo‐analytical profiling, physico‐chemical characterization, cytotoxicity, and stability to advance personalized medicine in drug development.
Marie Nevyhoštěná +7 more
wiley +1 more source
Advanced Science, Volume 13, Issue 46, 17 August 2026.Advanced delivery systems—including nanoparticles, nanoemulsions, liposomes, and hydrogels—protect food‐derived bioactive peptides from gastrointestinal degradation and bitterness. These systems enable pH‐responsive release, enhance intestinal absorption, and improve therapeutic efficacy against oxidative stress, metabolic disorders, cancer, and ...
Yu Xu +5 more
wiley +1 more source