Results 31 to 40 of about 3,252 (179)

Dissolution rate of ciprofloxacin and its cocrystal with resorcinol

ADMET and DMPK, 2018
The synthesis of cocrystals is presented as an alternative to improve the properties of active pharmaceutical ingredients, especially those related to solubility and dissolution rate.
Clara Ràfols, Hanan Fael, Elisabet Fuguet, Breeze Outhwaite, Samuel Lee, Rebeca Ruiz   +5 more
doaj   +1 more source

Statistical investigation of the full concentration range of fasted and fed simulated intestinal fluid on the equilibrium solubility of oral drugs [PDF]

, 2018
Upon oral administration the solubility of a drug in intestinal fluid is a key property influencing bioavailability. It is also recognised that simple aqueous solubility does not reflect intestinal solubility and to optimise in vitro investigations ...
Dunn, Claire, Halbert, Gavin, Khadra, Ibrahim, Perrier, Jeremy, Wilson, Clive G., Zhou, Zhou   +5 more
core   +1 more source

Advanced In Vivo Prediction by Introducing Biphasic Dissolution Data into PBPK Models

Pharmaceutics, 2023
Coupling biorelevant in vitro dissolution with in silico physiological-based pharmacokinetic (PBPK) tools represents a promising method to describe and predict the in vivo performance of drug candidates in formulation development including non-passive ...
Alexander Denninger, Tim Becker, Ulrich Westedt, Karl G. Wagner   +3 more
doaj   +1 more source

Albendazole Solid Dispersions: Influence of Dissolution Medium Composition on In Vitro Drug Release [PDF]

, 2014
The rate-limiting step to drug absorption is often dissolution from the dosage form, especially for poorly soluble com-pounds. Two possibilities for improving the dissolution of these drugs are to increase the available surface area and to im-prove their
Allemandi, Daniel Alberto, Castro, Silvina Gabriela, González Vidal, Noelia Luján, Palma, Santiago Daniel, Sanchez Bruni, Sergio Fabian   +4 more
core   +1 more source

Biorelevant test for supersaturable formulation

Asian Journal of Pharmaceutical Sciences, 2017
Supersaturable formulation can generate supersaturation after dissolution, providing kinetic advantage in vivo. However, the supersaturation may precipitate before being absorbed, which makes it difficult to ensure and predict its in vivo performance ...
Enxian Lu, Shoufeng Li, Zhongqin Wang
doaj   +1 more source

Dissolution of theophylline from extended-release tablets under cyclic retrograde peristaltic contractions in the Dynamic Colon Model

British Journal of Pharmacy, 2022
The dynamic colon model isa biorelevant in vitro model of the human proximal colon. In vivo, the large intestine mixes its contents using peristaltic waves that propagate both forwards(antegrade) and backwards (retrograde).
Connor O'Farrell, Konstantinos Stamatopoulos , Mark J. H. Simmons, Hannah Batchelor   +3 more
doaj   +1 more source

Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range [PDF]

, 2016
Solubility can be the absorption limiting factor for drug candidates and is therefore a very important input parameter for oral exposure prediction of compounds with limited solubility.
Bernard Faller, Frank H. Seiler, Jörg Berghausen, Nathalie Gobeau   +3 more
core   +3 more sources

Study of the impact of different salts on the intrinsic dissolution rate of pharmaceutical compounds [PDF]

, 2017
The intrinsic dissolution rate (IDR) of a free base and its four salts were investigated with the aim of selecting the salt with the best dissolution performance.
Box, Karl, Lee, Sam, Outhwaite, Breeze, Ruiz, Rebeca   +3 more
core   +1 more source

European Paediatric Formulation Initiative (EuPFI)-Formulating Ideas for Better Medicines for Children. [PDF]

, 2017
© American Association of Pharmaceutical Scientists 2016, published by Springer US, available online at doi: https://doi.org/10.1208/s12249-016-0584-1The European Paediatric Formulation Initiative (EuPFI), founded in 2007, aims to promote and facilitate ...
C Tuleu, Catherine Tuleu, F Liu, F Liu, Fang Liu, H Batchelor, H Batchelor, H Wachtel, Hannah Batchelor, HK Batchelor, J Walsh, J Walsh, J Walsh, J Walsh, J Walsh, Jenny Walsh, M Pein, Roy Turner, S Salunke, S Salunke, S Salunke, S Salunke, S Salunke, S Salunke, Smita Salunke, T Nunn, T Sam, TB Ernest, Tzuchi Rob Ju   +28 more
core   +4 more sources

Modelling the impact of atherosclerosis on drug release and distribution from coronary stents [PDF]

, 2015
Although drug-eluting stents (DES) are now widely used for the treatment of coronary heart disease, there remains considerable scope for the development of enhanced designs which address some of the limitations of existing devices.
A Neubert, A Schiavone, A Seidlitz, A Tan, A Tellez, AD Levin, AR Tzafriri, AR Tzafriri, AR Tzafriri, AV Finn, B Semmling, BE Bierer, C Bernelli, C Yang, C. M. McKittrick, C. McCormick, CC O’Brien, CC O’Brien, CJ Creel, CP Naseerali, CW Hwang, CW Hwang, F Bozsak, G Douglas, G Mani, G Nakazawa, G Vairo, GE Ragkousis, GS Getz, H Hara, H Jia, HJ Kuh, HQ Zhao, IB Menown, J Guo, J Watt, J Wiebe, JF Granada, JL Fan, JM Weiler, K Milewski, K. G. Oldroyd, KB Biggs, KR Kamath, LE Perkins, M Kamberi, M Rattazzi, MA Ewart, MA Lovich, MF Prescott, P Coats, P Zunino, R Mongrain, R Virmani, RS Schwartz, RS Schwartz, S Hossainy, S McGinty, S McGinty, S McGinty, S McGinty, S Morlacchi, S Prabhu, S Simsekyilmaz, S. Kennedy, S. McGinty, SK Yazdani, SN Iqbal, T Inoue, T Watanabe, U Baber, VY Hoymans, W Khan, W Khan, W Zhu, WC Carlyle, WJ Denny, X Zhu, Y Nakashima, Y Wang, ZA Ali   +80 more
core   +2 more sources