Silodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated saliva [PDF]
, 2019 Sublingual film dosage forms for drugs used for fast symptomatic treatment have promise because they allow a rapid onset of action. The aim of this study was to prepare films of silodosin intended for sublingual administration for the symptomatic ...
Adair +57 more
core +2 more sources
In vitro dissolution models for the prediction of in vivo performance of an oral mesoporous silica formulation [PDF]
, 2017 Drug release from mesoporous silica systems has been widely investigated in vitro using USP Type II (paddle) dissolution apparatus. However, it is not clear if the observed enhanced in vitro dissolution can forecast drug bioavailability in vivo.
Ahern, Robert J. +7 more
core +1 more source
Pharmaceuticals, 2022 Herein, a simple and rapid HPLC method for the determination of paracetamol milk-containing biorelevant media is proposed. The separation of the analyte from the milk-containing biorelevant media was accomplished isocratically using a mobile phase ...
Natalia Manousi +4 more
doaj +1 more source
Biopharmaceutical classification of poorly soluble drugs with respect to “enabling formulations” [PDF]
, 2013 The large number of drug candidates with poor dissolution characteristics seen in the past decade, has fostered interest in so-called "enabling formulations", i.e., formulations which shall make such drugs bio-available.
Brandl, Martin +3 more
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Pharmaceutics, 2021 For colonic drug delivery, the ascending part of the colon is the most favourable site as it offers the most suitable environmental conditions for drug dissolution.
Michael Schütt +4 more
doaj +1 more source
Dissolution Behavior of Flufenamic Acid in Heated Mixtures with Nanocellulose
Molecules, 2020 Flufenamic acid (FFA) is a problem drug that has up to eight different polymorphs and shows poor solubility. Variability in bioavailability has been reported in the past resulting in limited use of FFA in the oral solid dosage form.
Athanasios Mantas, Albert Mihranyan
doaj +1 more source
3D printing of medicines: Engineering novel oral devices with unique design and drug release characteristics [PDF]
, 2015 YesThree dimensional printing (3DP) was used to engineer novel oral drug delivery devices, with specialised design configurations loaded with multiple actives, with applications in personalised medicine.
Abdul W. Basit +7 more
core +1 more source
Development of Mucoadhesive Gel Microbicide to Target Mucosal HIV Reservoirs [PDF]
, 2014 The wide use of microbicide is mainly depends on its effectiveness, less frequent application, ready availability and most importantly cost. The aim of this work was to develop affordable microbicide mucoadhesive gel formulation of synthetic anti HIV ...
Shegokar, Ranjita, Singh, Kamalinder K
core +1 more source
Variable-focus microscopy and UV surface dissolution imaging as complementary techniques in intrinsic dissolution rate determination [PDF]
, 2017 This work reports a novel approach to the assessment of the surface properties of compacts used in Surface Dissolution Imaging (SDI). SDI is useful for determining intrinsic dissolution rate (IDR), an important parameter in early stage drug development ...
Asare-Addo, Kofi +6 more
core +1 more source
Pharmaceutics, 2023 Gastric mechanical stress often impacts drug dissolution from solid oral dosage forms, but in vitro experiments cannot recreate the substantial variability of gastric motility in a reasonable time.
Marcela Staniszewska +8 more
doaj +1 more source