Results 21 to 30 of about 1,723 (196)
Pharmaceutics, 2021 A new cocrystal of Norfloxacin, a poorly soluble fluoroquinolone antibiotic, has been synthetized by a solvent-mediated transformation experiment in toluene, using resorcinol as a coformer. The new cocrystal exists in both anhydrous and monohydrate forms
Hanan Fael +4 more
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Hydrodynamics and mechanical stresses in pharmacopoeial and noncompendial dissolution testing [PDF]
Farmacja Polska, 2020 The first and an essential step of medication’s path inside the human body is a dissolution of an active pharmaceutical ingridient. A dissolution of oral dosage forms occurs as a result of physicochemical and mechanical stresses which are found in ...
Marcela Wiater +3 more
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In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A
Pharmaceutics, 2022 In vivo studies in mice provide a valuable model to test novel active pharmaceutical ingredients due to their low material need and the fact that mice are frequently used as a species for early efficacy models.
Tim Becker +16 more
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Pharmaceutics, 2022 Generally, some weakly basic insoluble drugs will undergo precipitate and redissolution after emptying from the stomach to the small intestinal, resulting in the limited ability to predict the absorption characteristics of compounds in advance ...
Miao Zhang +6 more
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Pharmaceutics, 2021 Highly lipophilic antimalarial drugs, artemether and lumefantrine, whilst an effective fixed-dose combination treatment to lower the malarial disease burden, are therapeutically hindered by low aqueous solubility and varied bioavailability.
Christi A. Wilkins +2 more
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Dissolution Testing of Single- and Dual-Component Thyroid Hormone Supplements
Separations, 2019 A method for the analysis of thyroid hormones by liquid chromatography-mass spectrometry was used for the dissolution testing of single- and dual-component thyroid hormone supplements via a two-stage biorelevant dissolution procedure.
Samantha L. Bowerbank +2 more
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Superiority of Mesoporous Silica-Based Amorphous Formulations over Spray-Dried Solid Dispersions
Pharmaceutics, 2022 The aim of this study was to compare the performance of two amorphous formulation strategies: mesoporous silica via solvent impregnation, and solid dispersions by spray drying. Poorly soluble fenofibrate was chosen as the model drug compound.
Hongwei Zhang +5 more
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Enhanced Dissolution of Naproxen by Combining Cocrystallization and Eutectic Formation
Pharmaceutics, 2021 Improving dissolution properties of active pharmaceutical ingredients (APIs) is a critical step in drug development with the increasing occurrence of sparingly soluble APIs.
Hakyeong Kim, Soeun Jang, Il Won Kim
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Mechanistic study of physicochemical and biochemical processes affecting intestinal absorption of the sesquiterpene lactone nobilin from multi-component systems in the Caco-2 model [PDF]
, 2015 The overall aim of this work was to investigate the intestinal absorption of the sesquiterpene lactone nobilin from the flowers of Anthemis nobilis L.
Thormann, U.
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Pharmaceuticals, 2022 Herein, a simple and rapid HPLC method for the determination of paracetamol milk-containing biorelevant media is proposed. The separation of the analyte from the milk-containing biorelevant media was accomplished isocratically using a mobile phase ...
Natalia Manousi +4 more
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