Results 11 to 20 of about 1,723 (196)
Brazilian Journal of Pharmaceutical Sciences, 2022 Dissolution is a key step in the uptake of oral drugs. In order to compare the behaviour of the dissolution of two formulations, the dissolution profile test was used. This assay must be discriminative and should mimic in vivo conditions. Many dissolution media described in pharmacopoeias are not predictive of bioavailability.
Hemilliano de Lemos +2 more
core +5 more sources
Separations, 2022 The rate at which oral tobacco-derived nicotine (OTDN) and snus pouches release nicotine into saliva is crucial to determine product performance.
Matthias M. Knopp +3 more
doaj +2 more sources
A REVIEW ON DEVELOPMENT OF BIORELEVANT DISSOLUTION MEDIUM
Journal of Drug Delivery and Therapeutics, 2014 Dissolution testing is a valuable tool that provides key information about bioavailability or bioequivalency as well as batch to batch consistency of drug. Since the number of poorly soluble drug is increasing, the selection of adequate dissolution test for these becomes more and more important. Biorelevant is a term, used to describe a medium that has
Bhagat, Nitin B
openaire +4 more sources
Application of biorelevant saliva-based dissolution for optimisation of orally disintegrating formulations of felodipine [PDF]
International Journal of Pharmaceutics, 2019 The oral cavity is of great importance to the performance of orally retained formulations, including: orally disintegrating tablets, taste-masked formulations, and buccal/sublingual delivery systems. With regards to in vitro dissolution assessment of these dosage forms, human saliva should be represented by the dissolution media.
Joseph Ali +6 more
openaire +3 more sources
Biorelevant dissolution media as a predictive tool for glyburide a class II drug
European Journal of Pharmaceutical Sciences, 2006 The purpose of this study was to predict the oral absorption of glyburide. Biorelevant dissolution methods, combined with permeability measurements and computational simulations, were used to predict the oral absorption of glyburide. The objective was to establish in vitro/in vivo correlations (IVIVCs) based on the biopharmaceutics drug classification ...
Raimar Löbenberg
exaly +4 more sources
Biorelevant test for supersaturable formulation
Asian Journal of Pharmaceutical Sciences, 2017 Supersaturable formulation can generate supersaturation after dissolution, providing kinetic advantage in vivo. However, the supersaturation may precipitate before being absorbed, which makes it difficult to ensure and predict its in vivo performance ...
Enxian Lu, Shoufeng Li, Zhongqin Wang
doaj +2 more sources
Pharmaceutics, 2023 Particle size reduction is a commonly used process to improve the solubility and the dissolution of drug formulations. The solubility of a drug in the gastrointestinal tract is a crucial parameter, because it can greatly influence the bioavailability ...
Dora Csicsák +2 more
exaly +3 more sources
Development of biorelevant media and dissolution tests for gastrointestinal disease states
, 2022 Standard biorelevant media reflect the average gastrointestinal (GI) physiology in healthy volunteers. The use of biorelevant media in in vitro experiments has become an important strategy to predict drug behaviour in vivo and is often combined with in silico tools in order to simulate drug plasma profiles over time.
Šegregur, Domagoj
openaire +3 more sources
The investigation of kinetics dissolution of prolonged indapamide drugs in biorelevant media
Сеченовский вестник, 2013 In the current work there was performed the development of the method of determination dissolution kinetics in biorelevant media of slightly soluble substance, for example indapamide. The method was validated in terms of specificity, linearity, precision,
E. Yu. Sannikova +3 more
doaj +1 more source
From In Vivo Predictive Dissolution to Virtual Bioequivalence: A GastroPlus®-Driven Framework for Generic Candesartan Cilexetil Tablets [PDF]
PharmaceuticalsBackground: Candesartan cilexetil, a Biopharmaceutics Classification System (BCS) II prodrug, demonstrates compromised bioavailability attributable to its limited aqueous solubility coupled with P-glycoprotein (P-gp)-mediated efflux and hepatic first ...
Hao Ruan +6 more
doaj +2 more sources