Results 11 to 20 of about 224,448 (162)

Biorelevant dissolution of candesartan cilexetil [PDF]

ADMET and DMPK, 2017
The choice of an appropriate medium for dissolution tests is an essential step during a dosage form development. The adequate design of dissolution testing enables forecasting in vivo behavior of drug formulation.
Lucie Gruberová, Bohumil Kratochvil
doaj   +2 more sources

From prediction to performance: In silico-supported formulation of amorphous solid dispersions for PROTAC NX-2127 [PDF]

International Journal of Pharmaceutics: X
The oral delivery of PROTACs is frequently limited by poor aqueous solubility and low membrane permeability, whereas early formulation development is often constrained by limited drug substance availability.
Alicia Stakemeier, Lukas Mild, Johannes Sievers, Jitka Kalasová, Kristina E. Steffens, Martin Kuentz, Christian Steinebach, Karl G. Wagner   +7 more
doaj   +2 more sources

Introducing a Novel Biorelevant In Vitro Dissolution Method for the Assessment of Nicotine Release from Oral Tobacco-Derived Nicotine (OTDN) and Snus Products

Separations, 2022
The rate at which oral tobacco-derived nicotine (OTDN) and snus pouches release nicotine into saliva is crucial to determine product performance.
Matthias M. Knopp, Nikolai K. Kiil-Nielsen, Anna E. Masser, Mikael Staaf   +3 more
doaj   +1 more source

Use of biorelevant dissolution media in dissolution tests as a predictive method of oral bioavailability

, 2022
Dissolution is a key step in the uptake of oral drugs. In order to compare the behaviour of the dissolution of two formulations, the dissolution profile test was used. This assay must be discriminative and should mimic in vivo conditions.
Rocha, Helvécio Vinícius Antunes, Lemos, Hemilliano, Prado, Livia Deris   +2 more
core   +2 more sources

Synthesis and Characterization of a New Norfloxacin/Resorcinol Cocrystal with Enhanced Solubility and Dissolution Profile

Pharmaceutics, 2021
A new cocrystal of Norfloxacin, a poorly soluble fluoroquinolone antibiotic, has been synthetized by a solvent-mediated transformation experiment in toluene, using resorcinol as a coformer. The new cocrystal exists in both anhydrous and monohydrate forms
Hanan Fael, Rafael Barbas, Rafel Prohens, Clara Ràfols, Elisabet Fuguet   +4 more
doaj   +1 more source

Hydrodynamics and mechanical stresses in pharmacopoeial and noncompendial dissolution testing [PDF]

Farmacja Polska, 2020
The first and an essential step of medication’s path inside the human body is a dissolution of an active pharmaceutical ingridient. A dissolution of oral dosage forms occurs as a result of physicochemical and mechanical stresses which are found in ...
Marcela Wiater, Dagmara Hoc, Jadwiga Paszkowska, Grzegorz Garbacz   +3 more
doaj   +1 more source

In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A

Pharmaceutics, 2022
In vivo studies in mice provide a valuable model to test novel active pharmaceutical ingredients due to their low material need and the fact that mice are frequently used as a species for early efficacy models.
Tim Becker, Anna K. Krome, Sahel Vahdati, Andrea Schiefer, Kenneth Pfarr, Alexandra Ehrens, Tilman Aden, Miriam Grosse, Rolf Jansen, Silke Alt, Thomas Hesterkamp, Marc Stadler, Marc P. Hübner, Stefan Kehraus, Gabriele M. König, Achim Hoerauf, Karl G. Wagner   +16 more
doaj   +1 more source

Characterizing the Physicochemical Properties of Two Weakly Basic Drugs and the Precipitates Obtained from Biorelevant Media

Pharmaceutics, 2022
Generally, some weakly basic insoluble drugs will undergo precipitate and redissolution after emptying from the stomach to the small intestinal, resulting in the limited ability to predict the absorption characteristics of compounds in advance ...
Miao Zhang, Bin Wu, Shudong Zhang, Lin Wang, Qin Hu, Dongyang Liu, Xijing Chen   +6 more
doaj   +1 more source

Can biorelevant media be simplified by using SLS and tween 80 to replace bile compounds? [PDF]

, 2013
In the scientific literature, the use of a surfactant is recommended for both designing quality control tests for water insoluble or sparingly water soluble drugs and for predicting the bioavailability of drugs from various types of formulations.
Taupitz, Thomas, Klein, Sandra
core   +1 more source

Dissolution Testing of Single- and Dual-Component Thyroid Hormone Supplements

Separations, 2019
A method for the analysis of thyroid hormones by liquid chromatography-mass spectrometry was used for the dissolution testing of single- and dual-component thyroid hormone supplements via a two-stage biorelevant dissolution procedure.
Samantha L. Bowerbank, Michelle G. Carlin, John R. Dean   +2 more
doaj   +1 more source