Results 51 to 60 of about 3,252 (179)

Recent advances in the engineering of nanosized active pharmaceutical ingredients: Promises and challenges [PDF]

, 2016
The advances in the field of nanotechnology have revolutionized the field of delivery of poorly soluble active pharmaceutical ingredients (APIs). Nanosized formulations have been extensively investigated to achieve a rapid dissolution and therefore ...
Al Shafiee, Maen, Kaialy, Waseem
core   +1 more source

Nickel(0)‐Catalyzed [2+2+2] Cycloadditions of Linked Bisdiynes with Diaryl Alkynes Generates D‐π‐A‐π‐D Bis(arylethynyl)indane‐Based Organic Frameworks as Noncytotoxic Probes for Ds‐DNA/Ds‐RNA

ChemistryEurope, Volume 4, Issue 4, April 2026.
Ni(0)‐catalyzed [2 + 2 + 2] cycloadditions of linked bisdiynes with diarylacetylenes generate highly fluorescent D‐π‐A‐π‐D bis(arylethynyl)indane dyes. They bind strongly to ds‐DNA and ‐RNA leading to significant fluorescence quenching, are nontoxic toward human cell lines, and have potential as multimodal fluorescence, CD, and Raman probes for ...
Robert Ricker, Dijana Pavlović Saftić, Sabine Lorenzen, Johannes Schneider, Alena Neudert, Michelle Kalizki, Johannes Krebs, Florian Kerner, Alexandra Friedrich, Ludwig Zapf, Nils Schopper, Maik Finze, Nina Vukadinović, Lucija Lulić Horvat, Ivo Piantanida, Todd B. Marder   +15 more
wiley   +1 more source

Developing Clinically Relevant Dissolution Specifications (CRDSs) for Oral Drug Products: Virtual Webinar Series

Pharmaceutics, 2022
A webinar series that was organised by the Academy of Pharmaceutical Sciences Biopharmaceutics focus group in 2021 focused on the challenges of developing clinically relevant dissolution specifications (CRDSs) for oral drug products.
Mark McAllister, Talia Flanagan, Susan Cole, Andreas Abend, Evangelos Kotzagiorgis, Jobst Limberg, Heather Mead, Victor Mangas-Sanjuan, Paul A. Dickinson, Andrea Moir, Xavier Pepin, Diansong Zhou, Christophe Tistaert, Aristides Dokoumetzidis, Om Anand, Maxime Le Merdy, David B. Turner, Brendan T. Griffin, Adam Darwich, Jennifer Dressman, Claire Mackie   +20 more
doaj   +1 more source

Structure–Property Correlation of Diacylglycerol‐Modified Lipid Bases: Crystallization and Dispersion Behaviors

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Medium‐chain diacylglycerols were incorporated into fully hydrogenated palm kernel oil stearin (FHPKS) to regulate crystallization behavior and melt–dispersion performance. Low DAG levels (5%–10%) promoted β′‐rich crystal networks and improved thermal responsiveness, establishing a structure–property framework for designing functional lipid bases ...
Jun Jin, Mingxuan Fang, Siyu Zhang
wiley   +1 more source

Formulation and characterization of an apigenin-phospholipid phytosome (APLC) for improved solubility, in vivo bioavailability, and antioxidant potential [PDF]

, 2016
The apigenin-phospholipid phytosome (APLC) was developed to improve the aqueous solubility, dissolution, in vivo bioavailability, and antioxidant activity of apigenin.
Anand, Sridhar, Dave, Vivek S., Fegade, Harshal, Patin, Arun T., Pethe, Anil M., Telange, Darshan R.   +5 more
core   +2 more sources

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Coherent anti-Stokes Raman Scattering (CARS) Microscopy Visualizes Pharmaceutical Tablets During Dissolution [PDF]

, 2014
Traditional pharmaceutical dissolution tests determine the amount of drug dissolved over time by measuring drug content in the dissolution medium. This method provides little direct information about what is happening on the surface of the dissolving ...
Fussell, A.L., Herek, J.L., Kleinebudde, P., Offerhaus, H.L., Strachan, C.J.   +4 more
core   +3 more sources

Organic Electrochemical Transistors for Neuromorphic Devices and Applications

Advanced Materials, Volume 38, Issue 9, 12 February 2026.
Organic electrochemical transistors are emerging as promising platforms for neuromorphic devices that emulate neuronal and synaptic activities and can seamlessly integrate with biological systems. This review focuses on resultant organic artificial neurons, synapses, and integrated devices, with an emphasis on their ability to perform neuromorphic ...
Kexin Xiang, Jiajun Song, Hong Liu, Junxin Chen, Feng Yan   +4 more
wiley   +1 more source

Development and Validation of a Robust and Efficient HPLC Method for the Simultaneous Quantification of Levodopa, Carbidopa, Benserazide and Entacapone in Complex Matrices

Journal of Pharmacy & Pharmaceutical Sciences, 2017
Purpose: A variety of fixed-dose combination products is used in the therapy of Parkinson Disease. However, to date a proper analytical method applicable for comparative screening of different antiparkinson products was not available.
Erik Wollmer, Sandra Klein
doaj   +1 more source

In vitro and in vivo assessment of hydroxypropyl cellulose as functional additive for enabling formulations containing itraconazole

International Journal of Pharmaceutics: X, 2021
Using polymers as additives to formulate ternary amorphous solid dispersions (ASDs) has successfully been established to increase the bioavailability of poorly soluble drugs, when one polymer is not able to provide both, stabilizing the drug in the ...
Rafael D. Bachmaier, Marius Monschke, Thilo Faber, Anna K. Krome, Yann Pellequer, Edmont Stoyanov, Alf Lamprecht, Karl G. Wagner   +7 more
doaj   +1 more source