Results 51 to 60 of about 1,723 (196)

Charge Regulation in Crowded Solutions of a Weak Polyelectrolyte: Steric Interactions

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
Weak polyelectrolytes (WPE) solvated in biorelevant media and synthetic complex fluids that contain substantial concentrations of macromolecules, molecular assemblies, and nanoparticles are observed to exhibit deviations from the acid–base equilibrium observed in single‐component solutions.
David Attia, Evgenee Yekymov, Rachel Yerushalmi‐Rozen   +2 more
wiley   +1 more source

Randomized, Placebo‐Controlled, First‐in‐Human Study of the Safety, Tolerability, and Pharmacokinetics of Single and Repeat Oral Doses of Novel Antitubercular Drug Candidate, GSK2556286, in Healthy Adults

The Journal of Clinical Pharmacology, Volume 66, Issue 5, May 2026.
Abstract This first‐in‐human study (ClinicalTrials.gov identifier: NCT04472897) evaluated the safety, tolerability, pharmacokinetics, and food effect of single ascending and repeat oral doses of GSK2556286 (GSK286), a novel antitubercular drug candidate with efficacy in animal models of tuberculosis.
Emma Ilsley, Edward Banham‐Hall, Tetyana Chaychenko, Katerina Chinenyeze, Gareth Maher‐Edwards, Catherine Muya, Katie Rolfe, Raman Sharma, Simon Tiberi, David Barros‐Aguirre   +9 more
wiley   +1 more source

The dissolution test in biorelevant media as a prognostic tool for modeling of drug behavior in vivo [PDF]

Biomeditsinskaya Khimiya, 2011
The review deals with the modern tool for modeling of drug behavior in vivo, - the dissolution test in biorelevant media, imitating gastrointestinal fluids. The formulations and preparation methods of fasted state simulation intestinal fluid, FaSSIF and fed state simulation intestinal fluid, FeSSIF, are defined.
G V, Ramenskaia, I E, Shokhin, A Iu, Savchenko, E A, Volkova   +3 more
openaire   +2 more sources

Developing Clinically Relevant Dissolution Specifications (CRDSs) for Oral Drug Products: Virtual Webinar Series

Pharmaceutics, 2022
A webinar series that was organised by the Academy of Pharmaceutical Sciences Biopharmaceutics focus group in 2021 focused on the challenges of developing clinically relevant dissolution specifications (CRDSs) for oral drug products.
Mark McAllister, Talia Flanagan, Susan Cole, Andreas Abend, Evangelos Kotzagiorgis, Jobst Limberg, Heather Mead, Victor Mangas-Sanjuan, Paul A. Dickinson, Andrea Moir, Xavier Pepin, Diansong Zhou, Christophe Tistaert, Aristides Dokoumetzidis, Om Anand, Maxime Le Merdy, David B. Turner, Brendan T. Griffin, Adam Darwich, Jennifer Dressman, Claire Mackie   +20 more
doaj   +1 more source

Uracil–Peptide–Pyrene Conjugates as Cu2+‐Sensitive Probes Targeting DNA, RNA, and Biorelevant Model Membranes

ChemBioChem, Volume 27, Issue 8, April 2026.
We introduce uracil–triazole–pyrene peptidomimetics whose tunable peptide linkers precisely control light emission, copper binding, and interactions with DNA and RNA. Fine structural adjustments unlock selective biomolecular recognition and striking metal‐ and membrane‐responsive fluorescence, paving the way for a new generation of multifunctional ...
Dijana Pavlović Saftić, Lucija Lulić Horvat, Ivo Piantanida   +2 more
wiley   +1 more source

Biorelevant drug release of Metformin dosage forms using complementary in vitro tools

British Journal of Pharmacy, 2017
Drug release from immediate release (IR) and extended release (ER) metformin products was investigated using the Dow Chemical Company’s FloVitroTM biorelevant dissolution instrument.
Karl Box, Patrick O'Dwyer, Hayley Watson
doaj   +1 more source

Nickel(0)‐Catalyzed [2+2+2] Cycloadditions of Linked Bisdiynes with Diaryl Alkynes Generates D‐π‐A‐π‐D Bis(arylethynyl)indane‐Based Organic Frameworks as Noncytotoxic Probes for Ds‐DNA/Ds‐RNA

ChemistryEurope, Volume 4, Issue 4, April 2026.
Ni(0)‐catalyzed [2 + 2 + 2] cycloadditions of linked bisdiynes with diarylacetylenes generate highly fluorescent D‐π‐A‐π‐D bis(arylethynyl)indane dyes. They bind strongly to ds‐DNA and ‐RNA leading to significant fluorescence quenching, are nontoxic toward human cell lines, and have potential as multimodal fluorescence, CD, and Raman probes for ...
Robert Ricker, Dijana Pavlović Saftić, Sabine Lorenzen, Johannes Schneider, Alena Neudert, Michelle Kalizki, Johannes Krebs, Florian Kerner, Alexandra Friedrich, Ludwig Zapf, Nils Schopper, Maik Finze, Nina Vukadinović, Lucija Lulić Horvat, Ivo Piantanida, Todd B. Marder   +15 more
wiley   +1 more source

Structure–Property Correlation of Diacylglycerol‐Modified Lipid Bases: Crystallization and Dispersion Behaviors

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Medium‐chain diacylglycerols were incorporated into fully hydrogenated palm kernel oil stearin (FHPKS) to regulate crystallization behavior and melt–dispersion performance. Low DAG levels (5%–10%) promoted β′‐rich crystal networks and improved thermal responsiveness, establishing a structure–property framework for designing functional lipid bases ...
Jun Jin, Mingxuan Fang, Siyu Zhang
wiley   +1 more source

Development and Validation of a Robust and Efficient HPLC Method for the Simultaneous Quantification of Levodopa, Carbidopa, Benserazide and Entacapone in Complex Matrices

Journal of Pharmacy & Pharmaceutical Sciences, 2017
Purpose: A variety of fixed-dose combination products is used in the therapy of Parkinson Disease. However, to date a proper analytical method applicable for comparative screening of different antiparkinson products was not available.
Erik Wollmer, Sandra Klein
doaj   +1 more source

In vitro and in vivo assessment of hydroxypropyl cellulose as functional additive for enabling formulations containing itraconazole

International Journal of Pharmaceutics: X, 2021
Using polymers as additives to formulate ternary amorphous solid dispersions (ASDs) has successfully been established to increase the bioavailability of poorly soluble drugs, when one polymer is not able to provide both, stabilizing the drug in the ...
Rafael D. Bachmaier, Marius Monschke, Thilo Faber, Anna K. Krome, Yann Pellequer, Edmont Stoyanov, Alf Lamprecht, Karl G. Wagner   +7 more
doaj   +1 more source